公开(公告)号：US20160326184A1

公开(公告)日：2016-11-10

申请号：US14989600

申请日：2016-01-06

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Jean-Jacques Alexandre Cadieux ,  Mikhail Chafeev ,  Sultan Chowdhury ,  Jianmin FU ,  Qi Jia ,  Stefanie Abel ,  Emad El-Sayed ,  Elke Huthmann ,  Thomas Isarno

IPC: C07D491/20 ,  C07D405/04

CPC classification number: C07D491/20 ,  C07D405/04

Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US20140336390A1

公开(公告)日：2014-11-13

申请号：US14272297

申请日：2014-05-07

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Jacques Alexandre Cadieux ,  Mikhail Chafeev ,  Sultan Chowdhury ,  Jianmin Fu ,  Qi Ji ,  Stefanie Abel ,  Emad El-Sayed ,  Elke Huthmann ,  Thomas Isarno

IPC: C07D491/20

CPC classification number: C07D491/20 ,  C07D405/04

Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract translation: 本发明涉及制备某些螺 - 羟吲哚衍生物的方法，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。

公开(公告)号：US09695185B2

公开(公告)日：2017-07-04

申请号：US14989600

申请日：2016-01-06

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Jean-Jacques Alexandre Cadieux ,  Mikhail Chafeev ,  Sultan Chowdhury ,  Jianmin Fu ,  Qi Jia ,  Stefanie Abel ,  Emad El-Sayed ,  Elke Huthmann ,  Thomas Isarno

IPC: C07D491/20 ,  C07D405/04

CPC classification number: C07D491/20 ,  C07D405/04

Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US09260446B2

公开(公告)日：2016-02-16

申请号：US14272297

申请日：2014-05-07

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Jacques Alexandre Cadieux ,  Mikhail Chafeev ,  Sultan Chowdhury ,  Jianmin Fu ,  Qi Ji ,  Stefanie Abel ,  Emad El-Sayed ,  Elke Huthmann ,  Thomas Isarno

IPC: C07D491/20

CPC classification number: C07D491/20 ,  C07D405/04

Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.