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1.发明授权Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents 有权用作治疗剂的螺 - 羟吲哚化合物的不对称合成公开(公告)号：US09487535B2
公开(公告)日：2016-11-08
申请号：US13794147
申请日：2013-03-11
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Shaoyi Sun , Jianmin Fu , Sultan Chowdhury , Ivan William Hemeon , Michael Edward Grimwood , Tarek Suhayl Mansour
IPC: C07D491/20 , C07D209/34 , C07D405/10 , C07D491/107
CPC classification number: C07D491/20 , C07D209/34 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D491/107
Abstract: This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及某些螺 - 羟吲哚衍生物的不对称合成，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。
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2.发明申请ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 有权螺旋体化合物的使用者及其作为治疗剂的用途公开(公告)号：US20150025121A1
公开(公告)日：2015-01-22
申请号：US14510634
申请日：2014-10-09
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Jianmin Fu , Jean-Jacques Alexandre Cadieux
IPC: A61K31/407 , C07D491/20
CPC classification number: C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
Abstract: This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
Abstract translation: 本发明涉及式（I）化合物的（S） - 对映异构体：或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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3.发明申请ASYMMETRIC SYNTHESES FOR SPIRO-OXINDOLE COMPOUNDS USEFUL AS THERAPEUTIC AGENTS 审中-公开用作治疗药物的螺旋氧化合物的不对称合成公开(公告)号：US20170066777A1
公开(公告)日：2017-03-09
申请号：US15265549
申请日：2016-09-14
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Shaoyi Sun , Jianmin Fu , Sultan Chowdhury , Ivan William Hemeon , Michael Edward Grimwood , Tarek Suhayl Mansour
IPC: C07D491/20 , C07D405/14 , C07D405/04 , C07D405/06
CPC classification number: C07D491/20 , C07D209/34 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D491/107
Abstract: This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及某些螺 - 羟吲哚衍生物的不对称合成，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20150291623A1
公开(公告)日：2015-10-15
申请号：US14542367
申请日：2014-11-14
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/20 , C07D519/00 , C07D491/22 , C07D491/20 , C07D498/20
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20140336390A1
公开(公告)日：2014-11-13
申请号：US14272297
申请日：2014-05-07
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Jacques Alexandre Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Ji , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC: C07D491/20
CPC classification number: C07D491/20 , C07D405/04
Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及制备某些螺 - 羟吲哚衍生物的方法，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。
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Patent Agency Ranking
6.发明授权Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents 有权螺 - 羟吲哚化合物的对映异构体及其用作治疗剂公开(公告)号：US09480677B2
公开(公告)日：2016-11-01
申请号：US14510634
申请日：2014-10-09
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Jianmin Fu , Jean-Jacques Alexandre Cadieux
IPC: A61K31/407 , C07D491/22 , C07D491/20
CPC classification number: C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
Abstract: This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
Abstract translation: 本发明涉及式（I）化合物的（S） - 对映异构体的制备方法：该（S） - 对映体可用于治疗疾病或病症如疼痛，其被改善或缓解 通过电压门控钠通道的调制。
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公开(公告)号：US09260446B2
公开(公告)日：2016-02-16
申请号：US14272297
申请日：2014-05-07
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Jacques Alexandre Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Ji , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC: C07D491/20
CPC classification number: C07D491/20 , C07D405/04
Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：US20170114075A1
公开(公告)日：2017-04-27
申请号：US15253369
申请日：2016-08-31
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/22 , C07D491/20 , C07D495/20 , C07D498/20 , C07D491/22 , C07D513/20 , C07D491/107
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：US09695185B2
公开(公告)日：2017-07-04
申请号：US14989600
申请日：2016-01-06
Applicant: XENON PHARMACEUTICALS INC.
Inventor： Jean-Jacques Alexandre Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC: C07D491/20 , C07D405/04
CPC classification number: C07D491/20 , C07D405/04
Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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10.发明申请ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 审中-公开螺旋体化合物的使用者及其作为治疗剂的用途公开(公告)号：US20170073351A1
公开(公告)日：2017-03-16
申请号：US15278759
申请日：2016-09-28
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Jianmin Fu , Jean-Jacques Alexandre Cadieux
IPC: C07D491/20 , C07B57/00
CPC classification number: C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
Abstract: This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
Abstract translation: 或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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