公开(公告)号：US20220234994A1

公开(公告)日：2022-07-28

申请号：US17673335

申请日：2022-02-16

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/20 ,  C07C227/18 ,  C07C271/22 ,  C07C269/06

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20230357130A1

公开(公告)日：2023-11-09

申请号：US18221075

申请日：2023-07-12

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

CPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20240351975A1

公开(公告)日：2024-10-24

申请号：US18676957

申请日：2024-05-29

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/16 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22

CPC分类号： C07C229/08 ,  C07C227/16 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20240092727A1

公开(公告)日：2024-03-21

申请号：US18239265

申请日：2023-08-29

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  XUESONG XU ,  XUAN ZHANG ,  JAMES TIEN ,  HAO-WEI SHIH ,  HSIN-YI HUANG

IPC分类号： C07C229/24 ,  A61K9/16 ,  A61K31/221

CPC分类号： C07C229/24 ,  A61K9/16 ,  A61K31/221 ,  C07B2200/13

摘要： Crystalline 4-((L-valyl)oxy)butanoic acid, methods of preparing crystalline 4-((L-valyl)oxy)butanoic acid, pharmaceutical compositions of crystalline 4-((L-valyl)oxy)butanoic acid, and methods of treatment using crystalline 4-((L-valyl)oxy)butanoic acid are disclosed.

公开(公告)号：US20220055982A1

公开(公告)日：2022-02-24

申请号：US17351550

申请日：2021-06-18

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20210130281A1

公开(公告)日：2021-05-06

申请号：US17149170

申请日：2021-01-14

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  XUESONG XU ,  XUAN ZHANG

IPC分类号： C07C69/78 ,  C07C255/57 ,  C07D213/79 ,  C07D213/80 ,  C07D309/12 ,  C07C271/22 ,  C07C271/34 ,  C07C69/612 ,  C07D317/64 ,  C07D333/38 ,  C07C229/08 ,  C07C233/47 ,  C07D207/16 ,  C07D307/68 ,  C07B59/00 ,  C07C69/76 ,  C07C69/24 ,  C07C229/36 ,  C07C69/608 ,  C07C317/44 ,  C07D277/56 ,  C07D211/46 ,  C07C69/738 ,  C07C69/28 ,  C07C69/22 ,  C07C69/34 ,  C07C69/618 ,  C07C69/74 ,  C07C69/96 ,  C07C229/34 ,  C07C317/14 ,  C07D207/12 ,  C07D211/44 ,  C07D277/30

摘要： Provided are prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.