公开(公告)号：US20130252962A1

公开(公告)日：2013-09-26

申请号：US13787558

申请日：2013-03-06

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Mikhail CHAFEEV ,  Sultan CHOWDHURY ,  Lauren FRASER ,  Jianmin FU ,  Jonathan LANGILLE ,  Shifeng LIU ,  Jianyu SUN ,  Shaoyi SUN ,  Serguei SVIRIDOV ,  Mark WOOD ,  Alla Yurevna ZENOVA ,  Qi JIA ,  Jean-Jacques Alexandre CADIEUX ,  Simon J. GAUTHIER ,  Amy Frances DOUGLAS ,  Tom HSIEH ,  Nagasree CHAKKA ,  Zoran CIKOJEVIC

IPC: C07D491/107 ,  C07D495/20 ,  C07D498/20 ,  C07D513/20 ,  C07D491/20

CPC classification number: C07D513/22 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20 ,  C07D491/22 ,  C07D495/20 ,  C07D498/20 ,  C07D513/20 ,  C07D519/00

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.