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公开(公告)号：US20190031607A1
公开(公告)日：2019-01-31
申请号：US16150070
申请日：2018-10-02
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07C235/52 , C07D209/02 , C07D401/10 , C07D205/04 , C07D207/22 , C07D211/20 , C07C235/42 , C07D211/38 , C07D409/06 , C07D265/30 , C07D413/12 , C07D263/26 , C07C235/54 , C07D417/12 , C07D305/08 , C07D213/69 , C07D403/04 , C07D231/06 , C07D209/52 , C07D221/22 , C07D209/54 , C07D403/12 , C07D211/60 , C07D207/10 , C07D401/12 , C07D471/08 , C07D413/14 , C07D207/08 , C07D405/10 , C07D403/14 , C07D451/02 , C07D401/14 , C07D263/04 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20160340309A1
公开(公告)日：2016-11-24
申请号：US15161085
申请日：2016-05-20
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Abid HASAN , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Shaoyi SUN , Andrew D. WHITE , Wei GONG , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: C07D211/22 , C07D211/34 , C07D405/08 , C07D401/04 , C07D401/08 , C07D211/42 , C07D221/20 , C07D211/48 , C07D401/12
CPC classification number: C07D211/22 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/48 , C07D211/62 , C07D221/20 , C07D401/04 , C07D401/08 , C07D401/12 , C07D405/08
Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供了具有钠通道活性的化合物（例如，NaV1.7）抑制剂，其可用于治疗钠通道介导的疾病或病症，例如疼痛，以及与钠通道调停相关的其它疾病和病症，以及 含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20180265465A1
公开(公告)日：2018-09-20
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D471/08 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2103/74 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20210093618A1
公开(公告)日：2021-04-01
申请号：US16677487
申请日：2019-11-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian Salvatore SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , C07D295/26 , A61K31/4015 , C07D211/22 , C07D233/68 , C07D305/08 , C07D205/12 , A61K31/4523 , C07D405/12 , C07D413/06 , C07D451/02 , C07D405/04 , C07D211/54 , C07D403/12 , C07D487/08 , C07D237/08 , C07D205/04 , C07D211/32 , A61K31/4412 , A61K31/415 , C07D401/04 , A61K31/337 , A61K31/495 , C07D211/60 , A61K31/4545 , C07D403/04 , C07D413/12 , C07D401/12 , C07D265/30 , C07D417/06 , C07D451/06 , C07D211/42 , A61K31/397 , C07F7/08 , C07D211/96 , C07D241/04 , C07D401/06 , C07D453/02 , C07D207/12 , C07D295/155
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20210078947A1
公开(公告)日：2021-03-18
申请号：US16702286
申请日：2019-12-03
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US20160009710A1
公开(公告)日：2016-01-14
申请号：US14772735
申请日：2014-03-14
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Paul Robert BICHLER , Sultan CHOWDHURY , Shannon Marie DECKER , Christopher Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian SAFINA , Tao SHENG , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D471/08 , C07D519/00
Abstract: The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有以下通式的化合物：[插入式（I）]（I）及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，R1，R2，R3 ，R4和RN具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20170190662A1
公开(公告)日：2017-07-06
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07C235/54 , C07D401/12 , C07D277/06 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D405/10 , C07D471/08
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2103/74 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20170087136A1
公开(公告)日：2017-03-30
申请号：US15275131
申请日：2016-09-23
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , A61K31/4545 , A61K31/4523
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variablesRA, RAA, subscipt n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20150252038A1
公开(公告)日：2015-09-10
申请号：US14603273
申请日：2015-01-22
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: C07D453/02 , C07D205/04 , C07D401/06 , C07D403/12 , C07D401/12 , C07D211/42
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.
Abstract translation: 本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20130252962A1
公开(公告)日：2013-09-26
申请号：US13787558
申请日：2013-03-06
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail CHAFEEV , Sultan CHOWDHURY , Lauren FRASER , Jianmin FU , Jonathan LANGILLE , Shifeng LIU , Jianyu SUN , Shaoyi SUN , Serguei SVIRIDOV , Mark WOOD , Alla Yurevna ZENOVA , Qi JIA , Jean-Jacques Alexandre CADIEUX , Simon J. GAUTHIER , Amy Frances DOUGLAS , Tom HSIEH , Nagasree CHAKKA , Zoran CIKOJEVIC
IPC: C07D491/107 , C07D495/20 , C07D498/20 , C07D513/20 , C07D491/20
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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