公开(公告)号：US20090205061A1

公开(公告)日：2009-08-13

申请号：US12406334

申请日：2009-03-18

申请人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

发明人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

IPC分类号： A01K67/027 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N5/08 ,  C07K14/00 ,  C12Q1/68 ,  C12P21/02 ,  G01N33/566 ,  C12N1/21 ,  C07K16/18

CPC分类号： C07K14/705

摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.

摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。

公开(公告)号：US20120184459A1

公开(公告)日：2012-07-19

申请号：US13430273

申请日：2012-03-26

申请人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

发明人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

IPC分类号： C40B30/04 ,  C12N15/63 ,  C12N5/10 ,  C07K16/28 ,  C07K14/705 ,  C12Q1/68 ,  C12P21/02 ,  G01N33/566 ,  C12N15/12 ,  C12N1/21

CPC分类号： C07K14/705

摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.

摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。

公开(公告)号：US08173769B2

公开(公告)日：2012-05-08

申请号：US12406334

申请日：2009-03-18

申请人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

发明人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

IPC分类号： C07K14/705 ,  C07K19/00

CPC分类号： C07K14/705

摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.

摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。

公开(公告)号：US08710186B2

公开(公告)日：2014-04-29

申请号：US13430273

申请日：2012-03-26

申请人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

发明人： Xia Li ,  Weihua Li ,  Danielle R. Reed ,  Alexander A. Bachmanov ,  Joseph G. Brand

IPC分类号： C07K14/705

CPC分类号： C07K14/705

摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.

摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。