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公开(公告)号：US08168395B2
公开(公告)日：2012-05-01
申请号：US12428730
申请日：2009-04-23
申请人： Xia Li , Weihua Li , Joseph G. Brand
发明人： Xia Li , Weihua Li , Joseph G. Brand
IPC分类号： C07K14/705 , C07K19/00 , G01N33/567 , C12N15/62
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q2600/124 , C12Q2600/158
摘要： The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家犬（Canine familiaris）的几种基因的发现。 本发明特别提供了犬Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如狗）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US20070287154A1
公开(公告)日：2007-12-13
申请号：US11578472
申请日：2005-04-14
申请人： Xia Li , Weihua Li , Joseph Brand
发明人： Xia Li , Weihua Li , Joseph Brand
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q2600/124 , C12Q2600/158
摘要： The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家犬（Canine familiaris）的几种基因的发现。 本发明特别提供了犬Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如狗）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US20120184459A1
公开(公告)日：2012-07-19
申请号：US13430273
申请日：2012-03-26
申请人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
发明人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
IPC分类号： C40B30/04 , C12N15/63 , C12N5/10 , C07K16/28 , C07K14/705 , C12Q1/68 , C12P21/02 , G01N33/566 , C12N15/12 , C12N1/21
CPC分类号： C07K14/705
摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US08173769B2
公开(公告)日：2012-05-08
申请号：US12406334
申请日：2009-03-18
申请人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
发明人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
IPC分类号： C07K14/705 , C07K19/00
CPC分类号： C07K14/705
摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US20090233379A1
公开(公告)日：2009-09-17
申请号：US12428730
申请日：2009-04-23
申请人： Xia Li , Weihua Li , Joseph G. Brand
发明人： Xia Li , Weihua Li , Joseph G. Brand
IPC分类号： G01N33/566 , C12N15/11 , C12N15/00 , C12N5/06 , C12N5/08 , C12N1/21 , C07K14/00 , C12Q1/68 , C12P21/02
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q2600/124 , C12Q2600/158
摘要： The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家犬（Canine familiaris）的几种基因的发现。 本发明特别提供了犬Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如狗）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US06180348B2
公开(公告)日：2001-01-30
申请号：US09287936
申请日：1999-04-07
申请人： Weihua Li
发明人： Weihua Li
IPC分类号： C12Q168
CPC分类号： C12Q1/6811 , C12Q2563/155 , C12Q2563/143 , C12Q2525/207
摘要： This invention relates to methods of preparing oligonucleotide libraries, isolating oligonucleotide aptamers to target molecules from the libraries, and using the aptamers to purify target molecules by affinity separation. Specific oligonucleotide aptamers to erythropoietin were isolated accordingly.
摘要翻译： 本发明涉及制备寡核苷酸文库的方法，从文库中分离靶向分子的寡核苷酸适体，以及使用适体通过亲和分离纯化靶分子。 相应地分离特异性的促红细胞生成素的寡核苷酸适体。
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公开(公告)号：US20090205061A1
公开(公告)日：2009-08-13
申请号：US12406334
申请日：2009-03-18
申请人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
发明人： Xia Li , Weihua Li , Danielle R. Reed , Alexander A. Bachmanov , Joseph G. Brand
IPC分类号： A01K67/027 , C12N15/11 , C12N15/00 , C12N5/06 , C12N5/08 , C07K14/00 , C12Q1/68 , C12P21/02 , G01N33/566 , C12N1/21 , C07K16/18
CPC分类号： C07K14/705
摘要： The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家猫（Felis catus）的几种基因的发现。 本发明特别提供了猫科动物Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如猫）的味道偏好，摄入反应或一般行为的方法。
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公开(公告)号：US08765912B2
公开(公告)日：2014-07-01
申请号：US13432816
申请日：2012-03-28
申请人： Xia Li , Weihua Li , Joseph G. Brand
发明人： Xia Li , Weihua Li , Joseph G. Brand
IPC分类号： C07K14/705
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q2600/124 , C12Q2600/158
摘要： The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.
摘要翻译： 本发明涉及与味觉相关的家犬（Canine familiaris）的几种基因的发现。 本发明特别提供了犬Tas1r1，Tas1r2和Tas1r3受体基因的核苷酸序列，由此编码的多肽的氨基酸序列以及针对多肽的抗体。 本发明还涉及用于筛选修饰基因的功能或活性的化合物的方法，由这种筛选鉴定的化合物以及鉴定的化合物的模拟物。 本发明还提供了通过施用影响基因的功能或活性的化合物或由其编码的多肽来修饰哺乳动物（例如狗）的味道偏好，摄入反应或一般行为的方法。
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