公开(公告)号：US08259470B2

公开(公告)日：2012-09-04

申请号：US13270045

申请日：2011-10-10

申请人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

发明人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

IPC分类号： H02M3/335 ,  H02H7/125

CPC分类号： H02M3/33592 ,  H02M1/32 ,  H02M3/33515 ,  Y02B70/1475

摘要： A control circuit, a control method, and a power supply device are provided. The control circuit includes an obtaining sub-circuit, adapted to obtain a voltage signal from a reverse surge current when the reverse surge current appears on a primary side of a switch power circuit of a synchronous rectification circuit; a maintaining sub-circuit, adapted to continuously output a first control signal in a preset first time period when the voltage signal is greater than a preset first voltage threshold; and a control sub-circuit, adapted to control and switch off switch tubes of the secondary side of the switch power circuit of the synchronous rectification circuit according to the first control signal. Thus, a reverse current surge of the switch power circuit of the synchronous rectification circuit can be effectively suppressed, and the safety of a switch power supply of the synchronous rectification circuit can be effectively protected.

摘要翻译： 提供控制电路，控制方法和电源装置。 所述控制电路包括获取子电路，用于当所述反向浪涌电流出现在同步整流电路的开关电源电路的初级侧时，从反向浪涌电流获得电压信号; 维持子电路，适于当所述电压信号大于预设的第一电压阈值时，在预设的第一时间段内连续地输出第一控制信号; 以及控制子电路，适于根据第一控制信号来控制和关断同步整流电路的开关电源电路的次级侧的开关管。 因此，能够有效地抑制同步整流电路的开关电源电路的反向电流浪涌，能够有效地保护同步整流电路的开关电源的安全性。

公开(公告)号：US09276485B2

公开(公告)日：2016-03-01

申请号：US12982197

申请日：2010-12-30

申请人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

发明人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

IPC分类号： H02M3/335 ,  H02M1/32

CPC分类号： H02M3/33592 ,  H02M1/32 ,  H02M3/33515 ,  Y02B70/1475

摘要： A control circuit, a control method, and a power supply device are provided. The control circuit includes an obtaining module, adapted to obtain a voltage signal from a reverse surge current when the reverse surge current appears on a primary side of a switch power circuit of a synchronous rectification circuit; a maintaining module, adapted to continuously output a first control signal in a preset first time period when the voltage signal is greater than a preset first voltage threshold; and a control module, adapted to control and switch off switch tubes of the secondary side of the switch power circuit of the synchronous rectification circuit according to the first control signal. Thus, a reverse current surge of the switch power circuit of the synchronous rectification circuit can be effectively suppressed, and the safety of a switch power supply of the synchronous rectification circuit can be effectively protected.

摘要翻译： 提供控制电路，控制方法和电源装置。 所述控制电路包括获取模块，用于当所述反向浪涌电流出现在同步整流电路的开关电源电路的初级侧时，从反向浪涌电流获得电压信号; 维持模块，适于当所述电压信号大于预设的第一电压阈值时，在预设的第一时间周期内连续地输出第一控制信号; 以及控制模块，其适于根据第一控制信号控制和断开同步整流电路的开关电源电路的次级侧的开关管。 因此，能够有效地抑制同步整流电路的开关电源电路的反向电流浪涌，能够有效地保护同步整流电路的开关电源的安全性。

公开(公告)号：US20120026756A1

公开(公告)日：2012-02-02

申请号：US13270045

申请日：2011-10-10

申请人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

发明人： Xiaodong Fan ,  Lei Feng ,  Fugao Zhao ,  Zhihua Liu

IPC分类号： H02M3/335

CPC分类号： H02M3/33592 ,  H02M1/32 ,  H02M3/33515 ,  Y02B70/1475

摘要： A control circuit, a control method, and a power supply device are provided. The control circuit includes an obtaining sub-circuit, adapted to obtain a voltage signal from a reverse surge current when the reverse surge current appears on a primary side of a switch power circuit of a synchronous rectification circuit; a maintaining sub-circuit, adapted to continuously output a first control signal in a preset first time period when the voltage signal is greater than a preset first voltage threshold; and a control sub-circuit, adapted to control and switch off switch tubes of the secondary side of the switch power circuit of the synchronous rectification circuit according to the first control signal. Thus, a reverse current surge of the switch power circuit of the synchronous rectification circuit can be effectively suppressed, and the safety of a switch power supply of the synchronous rectification circuit can be effectively protected.

摘要翻译： 提供控制电路，控制方法和电源装置。 所述控制电路包括获取子电路，用于当所述反向浪涌电流出现在同步整流电路的开关电源电路的初级侧时，从反向浪涌电流获得电压信号; 维持子电路，适于当所述电压信号大于预设的第一电压阈值时，在预设的第一时间段内连续地输出第一控制信号; 以及控制子电路，适于根据第一控制信号来控制和关断同步整流电路的开关电源电路的次级侧的开关管。 因此，能够有效地抑制同步整流电路的开关电源电路的反向电流浪涌，能够有效地保护同步整流电路的开关电源的安全性。

公开(公告)号：US20120032509A1

公开(公告)日：2012-02-09

申请号：US13272674

申请日：2011-10-13

申请人： Xiaodong Fan ,  Xiaming Jing ,  Zhihua Liu ,  Xujun Liu

发明人： Xiaodong Fan ,  Xiaming Jing ,  Zhihua Liu ,  Xujun Liu

IPC分类号： H02M3/335

CPC分类号： H02M3/33561 ,  H02M3/33592 ,  Y02B70/1475 ,  Y10T307/406

摘要： A voltage transforming device is provided, which includes: a first voltage transforming module, configured to perform a pre-stage voltage transformation on an input DC voltage to output an isolated DC voltage, in which the pre-stage voltage transformation includes a primary transformation that converts the input DC voltage to a to-be-transformed AC voltage, a working period of the primary transformation includes a first half period and a second half period, and a dead time exists when a first half period and a second half period are switched between each other; a capacitor filtering module, configured to perform capacitor filtering compensation on the isolated DC voltage in the dead time to output a stable intermediate DC voltage; and a second voltage transforming module, configured to perform at least two separate post-stage voltage transformations on the intermediate DC voltage to output DC voltages required by at least two loads.

摘要翻译： 提供了一种电压变换装置，其包括：第一电压变换模块，被配置为对输入DC电压执行前级电压变换以输出隔离的DC电压，其中所述前级电压变换包括主变换， 将输入直流电压转换为变换后的交流电压，一次变换的工作周期包括前半周期和后半周期，当切换前半周期和后半周期时，存在死区时间 彼此之间 电容滤波模块，被配置为在死区时间对隔离的直流电压进行电容滤波补偿，以输出稳定的中间直流电压; 以及第二电压变换模块，其被配置为对所述中间DC电压执行至少两个分离的后级电压变换，以输出至少两个负载所需的DC电压。

公开(公告)号：US20110241424A1

公开(公告)日：2011-10-06

申请号：US12980047

申请日：2010-12-28

申请人： Xiaodong Fan ,  Xiaming Jing ,  Zhihua Liu ,  Xujun Liu

发明人： Xiaodong Fan ,  Xiaming Jing ,  Zhihua Liu ,  Xujun Liu

IPC分类号： H02J1/00 ,  H02M3/335

CPC分类号： H02M3/33561 ,  H02M3/33592 ,  Y02B70/1475 ,  Y10T307/406

摘要： A voltage transforming device is provided, which includes: a first voltage transforming module, configured to perform a pre-stage voltage transformation on an input DC voltage to output an isolated DC voltage, in which the pre-stage voltage transformation includes a primary transformation that converts the input DC voltage to a to-be-transformed AC voltage; a capacitor filtering module, configured to perform capacitor filtering compensation on the isolated DC voltage in the dead time to output a stable intermediate DC voltage; and a second voltage transforming module, configured to perform at least two separate post-stage voltage transformations on the intermediate DC voltage to output DC voltages required by at least two loads. A voltage transforming method and a power supply system are also provided. Thereby, the decoupling of the pre-stage and post-stage working modes is achieved, and the interference suffered during voltage transformation is reduced.

摘要翻译： 提供了一种电压变换装置，其包括：第一电压变换模块，被配置为对输入DC电压执行前级电压变换以输出隔离的DC电压，其中所述前级电压变换包括主变换， 将输入直流电压转换为变换后的交流电压; 电容滤波模块，被配置为在死区时间对隔离的直流电压进行电容滤波补偿，以输出稳定的中间直流电压; 以及第二电压变换模块，其被配置为对所述中间DC电压执行至少两个分离的后级电压变换，以输出至少两个负载所需的DC电压。 还提供了电压变换方法和电源系统。 因此，实现了前级和后级工作模式的去耦，并且降低了电压转换期间的干扰。

公开(公告)号：US20110294794A1

公开(公告)日：2011-12-01

申请号：US13129360

申请日：2009-11-13

申请人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

发明人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

IPC分类号： A61K31/4174 ,  A61K31/4439 ,  A61K31/5513 ,  A61K31/4545 ,  A61P25/28 ,  A61P25/14 ,  A61P27/02 ,  A61P29/00 ,  A61P9/00 ,  A61P35/00 ,  A61P25/16 ,  A61K31/496 ,  A61P3/00

CPC分类号： A61K31/4178 ,  A61K31/4406 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/55 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

摘要： Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant.

摘要翻译： 提供了包含可用于治疗蛋白病的低剂量法呢基转移酶抑制剂的方法和药物组合物。 这些低剂量低于这些化合物最初设计的肿瘤治疗中使用的剂量。 该治疗包括向有需要的受试者施用治疗有效量的法呢基转移酶抑制剂，其中所述量有效地抑制参与自噬途径的非Ras FTase底物的法呢基化，而基本上不影响Ras或其它的法呢基化 肿瘤相关底物。 根据本发明的治疗还可以包括乙酰胆碱酯酶抑制剂，神经营养受体的激活剂，NMDA拮抗剂，淀粉样蛋白沉积抑制剂，抗精神病药，抗抑郁药，抗焦虑剂或抗氧化剂。

公开(公告)号：US20060106060A1

公开(公告)日：2006-05-18

申请号：US11084715

申请日：2005-03-18

申请人： Peter Lansbury ,  Zhihua Liu

发明人： Peter Lansbury ,  Zhihua Liu

IPC分类号： A61K31/4709

CPC分类号： A61K31/4709

摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject a farnesyl transferase inhibitor compound.

摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括对突触核蛋白病患者施用法呢基转移酶抑制剂化合物。

公开(公告)号：US20050288298A1

公开(公告)日：2005-12-29

申请号：US11084740

申请日：2005-03-18

申请人： Peter Lansbury ,  Zhihua Liu

发明人： Peter Lansbury ,  Zhihua Liu

IPC分类号： A61K31/473 ,  A61K31/496

CPC分类号： A61K31/473

摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject one or more farnesyl transferase inhibitor compounds.

摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括向突触核蛋白病患者施用一种或多种法呢基转移酶抑制剂化合物。

公开(公告)号：US20050277629A1

公开(公告)日：2005-12-15

申请号：US11084695

申请日：2005-03-18

申请人： Peter Lansbury ,  Zhihua Liu

发明人： Peter Lansbury ,  Zhihua Liu

IPC分类号： A61K31/497 ,  A61K31/551

CPC分类号： A61K31/497 ,  A61K31/222 ,  A61K31/4174 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06

摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject one or more farnesyl transferase inhibitor compounds.

摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括向突触核蛋白病患者施用一种或多种法呢基转移酶抑制剂化合物。

公开(公告)号：US20050272722A1

公开(公告)日：2005-12-08

申请号：US11084739

申请日：2005-03-18

申请人： Peter Lansbury ,  Zhihua Liu

发明人： Peter Lansbury ,  Zhihua Liu

IPC分类号： A61K31/5513

CPC分类号： A61K31/5513

摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject a farnesyl transferase inhibitor compound.

摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括对突触核蛋白病患者施用法呢基转移酶抑制剂化合物。