公开(公告)号：US07794959B2

公开(公告)日：2010-09-14

申请号：US12053855

申请日：2008-03-24

申请人： Xiaodong Li ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

发明人： Xiaodong Li ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

IPC分类号： G01N33/567 ,  C07K14/705

CPC分类号： C12Q1/6895 ,  G01N33/5008 ,  G01N33/566 ,  G01N2500/00

摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1 or hT2R67 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。 本发明还涉及这些T2R受体在用于鉴定通过水解大豆蛋白材料及其衍生物和相关化合物中存在的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。 此外，这些T2R配体可能被用作治疗和调节hT2R1或hT2R67相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病， 克罗恩病，乳糜泻等。

公开(公告)号：US20090074894A1

公开(公告)日：2009-03-19

申请号：US12053855

申请日：2008-03-24

申请人： Xiaodong LI ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

发明人： Xiaodong LI ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

IPC分类号： A61K36/48 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/566 ,  A23L1/20 ,  C12Q1/00 ,  C07K14/705

CPC分类号： C12Q1/6895 ,  G01N33/5008 ,  G01N33/566 ,  G01N2500/00

摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1 or hT2R67 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

摘要翻译： 本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。 本发明还涉及这些T2R受体在用于鉴定通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。 此外，这些T2R配体可能被用作治疗和调节hT2R1或hT2R67相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病， 克罗恩病，乳糜泻等。