公开(公告)号：US06218571B1

公开(公告)日：2001-04-17

申请号：US09428296

申请日：1999-10-27

申请人： Xiaoling Zheng ,  Yeung Siu Yu ,  Adva Yani ,  Paing C. Huang

发明人： Xiaoling Zheng ,  Yeung Siu Yu ,  Adva Yani ,  Paing C. Huang

IPC分类号： C07C30900

CPC分类号： C07C309/47 ,  C09B27/00 ,  C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  C12Q2326/32

摘要： 8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-2-benzothiazolinone hydrazone hydrchloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by the formula: wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.

摘要翻译： 提供了8-（苯胺基）-1-萘磺酸盐（ANS）类似物及其在分析物检测测定中的应用。 主题ANS类似物的特征在于在其苯基部分上具有至少一个非氢取代基，并产生与3-甲基-2-苯并噻唑啉酮腙盐酸盐（MBTH）或其类似物的反应产物。 MBTHSB，减少漂移。 在某些优选实施方案中，主题ANS类似物由下式描述：其中：n为1至5; X是除H之外的取代基。主题ANS类似物可用于各种应用，特别是在分析物检测测定中，例如葡萄糖检测测定。

公开(公告)号：US06989243B2

公开(公告)日：2006-01-24

申请号：US10155949

申请日：2002-05-24

申请人： Adva Yani ,  Paing C. Huang

发明人： Adva Yani ,  Paing C. Huang

IPC分类号： C12Q1/54

CPC分类号： C12Q1/54 ,  G01N33/521 ,  Y10S435/975

摘要： Methods for determining the concentration of an analyte, e.g. glucose, in a physiological sample, are provided. The subject methods use reagent test strips which include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent. The subject methods are particularly suited for use in the detection of blood glucose concentrations.

摘要翻译： 确定分析物浓度的方法，例如 提供生理样品中的葡萄糖。 主题方法使用试剂测试条，其包括分析物氧化信号产生系统的一个或多个成员和至少一种溶血剂。 本发明方法特别适用于检测血糖浓度。

公开(公告)号：US06998248B2

公开(公告)日：2006-02-14

申请号：US11001490

申请日：2004-11-30

申请人： Adva Yani ,  Paing C. Huang

发明人： Adva Yani ,  Paing C. Huang

IPC分类号： C12Q1/54

CPC分类号： C12Q1/54 ,  G01N33/521 ,  Y10S435/975

摘要： Reagent test strips and methods for their use in the determination of the concentration of an analyte, e.g. glucose, in a physiological sample, are provided. The subject reagent test strips include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent. The subject reagent test strips and methods are particularly suited for use in the detection of blood glucose concentrations. Also provided are kits that include the subject test strips for use in practicing the subject methods.

公开(公告)号：US06485923B1

公开(公告)日：2002-11-26

申请号：US09497631

申请日：2000-02-02

申请人： Adva Yani ,  Paing C. Huang

发明人： Adva Yani ,  Paing C. Huang

IPC分类号： C12Q154

CPC分类号： C12Q1/54 ,  G01N33/521 ,  Y10S435/975

摘要： Reagent test strips and methods for their use in the determination of the concentration of an analyte, e.g. glucose, in a physiological sample, are provided. The subject reagent test strips include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent. The subject reagent test strips and methods are particularly suited for use in the detection of blood glucose concentrations. Also provided are kits that include the subject test strips for use in practicing the subject methods.

摘要翻译： 试剂测试条及其用于测定分析物浓度的方法，例如 提供生理样品中的葡萄糖。 主题试剂测试条包括分析物氧化信号产生系统和至少一种溶血剂的一个或多个成员。 主题试剂测试条和方法特别适用于检测血糖浓度。 还提供了包括用于实践主题方法的主题测试条的试剂盒。

公开(公告)号：US20050095659A1

公开(公告)日：2005-05-05

申请号：US11001490

申请日：2004-11-30

申请人： Adva Yani ,  Paing Huang

发明人： Adva Yani ,  Paing Huang

IPC分类号： G01N31/22 ,  C12M1/34 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66

CPC分类号： C12Q1/54 ,  G01N33/521 ,  Y10S435/975

摘要： Reagent test strips and methods for their use in the determination of the concentration of an analyte, e.g. glucose, in a physiological sample, are provided. The subject reagent test strips include one or more members of an analyte oxidation signal producing system and at least one hemolyzing agent. The subject reagent test strips and methods are particularly suited for use in the detection of blood glucose concentrations. Also provided are kits that include the subject test strips for use in practicing the subject methods.

摘要翻译： 试剂测试条及其用于测定分析物浓度的方法，例如 提供生理样品中的葡萄糖。 主题试剂测试条包括分析物氧化信号产生系统和至少一种溶血剂的一个或多个成员。 主题试剂测试条和方法特别适用于检测血糖浓度。 还提供了包括用于实践主题方法的主题测试条的试剂盒。