公开(公告)号：US20100049290A1

公开(公告)日：2010-02-25

申请号：US12197957

申请日：2008-08-25

申请人： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Kevin L. Morgan ,  Martin Cholette ,  Phong D. Doan

发明人： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Kevin L. Morgan ,  Martin Cholette ,  Phong D. Doan

IPC分类号： A61N1/05

CPC分类号： A61N1/0563 ,  A61N1/086

摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.

摘要翻译： 本文公开了可植入医疗引线。 在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。 线圈在引线的近端和远端之间延伸。 远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

公开(公告)号：US08244375B2

公开(公告)日：2012-08-14

申请号：US12197957

申请日：2008-08-25

申请人： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Kevin L. Morgan ,  Martin Cholette ,  Phong D. Doan

发明人： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Kevin L. Morgan ,  Martin Cholette ,  Phong D. Doan

IPC分类号： A61N1/05

CPC分类号： A61N1/0563 ,  A61N1/086

摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.

摘要翻译： 本文公开了可植入医疗引线。 在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。 线圈在引线的近端和远端之间延伸。 远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

公开(公告)号：US20120215271A1

公开(公告)日：2012-08-23

申请号：US13450127

申请日：2012-04-18

申请人： Xiaoyi Min ,  Martin Cholette ,  J. Christopher Moulder

发明人： Xiaoyi Min ,  Martin Cholette ,  J. Christopher Moulder

IPC分类号： A61N1/37 ,  A61N1/39

CPC分类号： A61N1/3718 ,  A61N1/086

摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable, cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating.

摘要翻译： 提供的系统和方法用于减少起搏器或可植入的心律转复除颤器的起搏/感测引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源 （RF）领域。 例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽 以减少其中引起的环路电流的强度，从而减少尖端加热。

公开(公告)号：US20100106227A1

公开(公告)日：2010-04-29

申请号：US12257245

申请日：2008-10-23

申请人： Xiaoyi Min ,  Martin Cholette ,  J. Christopher Moulder

发明人： Xiaoyi Min ,  Martin Cholette ,  J. Christopher Moulder

IPC分类号： A61N1/05 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/3718 ,  A61N1/086

摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating. Techniques are also described herein for selectively disconnecting the tip electrode of the lead during an MRI procedure, except during actual delivery of pacing pulses, so as to permit delivery of individual pacing pulses to pacemaker dependent patients during the MRI. Still other techniques describe the use of both RF shielding and tip switching.

摘要翻译： 提供了系统和方法，用于减少起搏器或植入式心律转复除颤器的起搏/感应引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源（ RF）字段。 例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽 以减少其中引起的环路电流的强度，从而减少尖端加热。 本文还描述了在MRI过程期间选择性地断开引线的尖端电极的技术，除了在实际递送起搏脉冲之前，以便允许在MRI期间将起搏器依赖患者的单个起搏脉冲输送到起搏器依赖患者。 其他技术还描述了使用RF屏蔽和尖端切换。

公开(公告)号：US08099173B2

公开(公告)日：2012-01-17

申请号：US12393972

申请日：2009-02-26

申请人： J. Christopher Moulder ,  Martin Cholette

发明人： J. Christopher Moulder ,  Martin Cholette

IPC分类号： A61N1/00

CPC分类号： A61N1/37 ,  A61N1/3718

摘要： An implantable medical lead for coupling to an implantable pulse generator may be configured for improved safety. The lead may include: a first electrode; a second electrode in electrical communication with the first electrode; and an active circuit element in electrical communication with the first electrode and the second electrode. The active circuit element may be configured to change an impedance of the lead. The active circuit element may be configured to change the impedance of the lead in response to a pacing signal or a signal having opposite polarity to a pacing signal. A method of using an implantable medical lead for improved safety may include changing an impedance of an implantable medical lead from a relatively high impedance to a relatively low impedance and/or changing an impedance of an implantable medical lead from a relatively low impedance to a relatively high impedance.

摘要翻译： 用于耦合到可植入脉冲发生器的可植入医疗引线可以被配置为提高安全性。 引线可以包括：第一电极; 与所述第一电极电连通的第二电极; 以及与第一电极和第二电极电连通的有源电路元件。 有源电路元件可以被配置为改变引线的阻抗。 有源电路元件可以被配置为响应于起搏信号或与起搏信号具有相反极性的信号来改变引线的阻抗。 使用可植入医疗引线以改善安全性的方法可包括将可植入医疗引线的阻抗从相对高的阻抗改变为相对较低的阻抗和/或将可植入医疗引线的阻抗从相对较低的阻抗改变为相对较低的阻抗 高阻抗。

公开(公告)号：US20100217366A1

公开(公告)日：2010-08-26

申请号：US12393972

申请日：2009-02-26

申请人： J. Christopher Moulder ,  Martin Cholette

发明人： J. Christopher Moulder ,  Martin Cholette

IPC分类号： A61N1/05

CPC分类号： A61N1/37 ,  A61N1/3718

摘要： An implantable medical lead for coupling to an implantable pulse generator may be configured for improved safety. The lead may include: a first electrode; a second electrode in electrical communication with the first electrode; and an active circuit element in electrical communication with the first electrode and the second electrode. The active circuit element may be configured to change an impedance of the lead. The active circuit element may be configured to change the impedance of the lead in response to a pacing signal or a signal having opposite polarity to a pacing signal. A method of using an implantable medical lead for improved safety may include changing an impedance of an implantable medical lead from a relatively high impedance to a relatively low impedance and/or changing an impedance of an implantable medical lead from a relatively low impedance to a relatively high impedance.

摘要翻译： 用于耦合到可植入脉冲发生器的可植入医疗引线可以被配置为提高安全性。 引线可以包括：第一电极; 与所述第一电极电连通的第二电极; 以及与第一电极和第二电极电连通的有源电路元件。 有源电路元件可以被配置为改变引线的阻抗。 有源电路元件可以被配置为响应于起搏信号或与起搏信号具有相反极性的信号来改变引线的阻抗。 使用可植入医疗引线以改善安全性的方法可包括将可植入医疗引线的阻抗从相对高的阻抗改变为相对较低的阻抗和/或将可植入医疗引线的阻抗从相对较低的阻抗改变为相对较低的阻抗 高阻抗。

公开(公告)号：US08538553B2

公开(公告)日：2013-09-17

申请号：US12889189

申请日：2010-09-23

申请人： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

发明人： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N1/086

摘要： An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.

摘要翻译： 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。

公开(公告)号：US20110079423A1

公开(公告)日：2011-04-07

申请号：US12889189

申请日：2010-09-23

申请人： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

发明人： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

IPC分类号： H05K9/00 ,  H01F27/30

CPC分类号： A61N1/056 ,  A61N1/086

摘要： An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.

摘要翻译： 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。

公开(公告)号：US08923965B2

公开(公告)日：2014-12-30

申请号：US12976322

申请日：2010-12-22

申请人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

发明人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

IPC分类号： A61B1/00 ,  A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/365 ,  A61N1/36521

摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.

摘要翻译： 提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。 在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受 患者体内搏动量的变化。 此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。 在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。 描述了双心室和多部位左心室（MSLV）的例子。

公开(公告)号：US20120165892A1

公开(公告)日：2012-06-28

申请号：US12976322

申请日：2010-12-22

申请人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

发明人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/365 ,  A61N1/36521

摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.

摘要翻译： 提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。 在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受 患者体内搏动量的变化。 此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。 在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。 描述了双心室和多部位左心室（MSLV）的例子。