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公开(公告)号：US11014992B2
公开(公告)日：2021-05-25
申请号：US16881111
申请日：2020-05-22
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , C07K16/36 , A61K9/00 , A61K47/68 , A61K45/06 , A61K31/4192 , C07D249/04 , C07K16/30 , A61K47/54 , A61K47/64 , A61K47/55
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US20240067756A1
公开(公告)日：2024-02-29
申请号：US18206937
申请日：2023-06-07
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , A61K9/00 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/55 , A61K47/64 , A61K47/68 , C07D249/04 , C07K16/30
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US12084517B2
公开(公告)日：2024-09-10
申请号：US18206937
申请日：2023-06-07
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , A61K9/00 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/55 , A61K47/64 , A61K47/68 , C07D249/04 , C07K16/30
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US10703823B2
公开(公告)日：2020-07-07
申请号：US16045855
申请日：2018-07-26
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , C07K16/30 , A61K9/00 , A61K47/68 , A61K45/06 , A61K31/4192 , A61K47/54 , C07D249/04 , A61K47/64 , A61K47/55
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US10066026B2
公开(公告)日：2018-09-04
申请号：US15083025
申请日：2016-03-28
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , A61K9/00 , A61K45/06 , A61K47/48 , C07K16/30 , A61K31/4192 , C07D249/04
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US20160347863A1
公开(公告)日：2016-12-01
申请号：US15083025
申请日：2016-03-28
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/48023 , A61K47/48092 , A61K47/481 , A61K47/4833 , A61K47/48653 , A61K47/48723 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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7.发明授权公开(公告)号：US09296708B2
公开(公告)日：2016-03-29
申请号：US14480204
申请日：2014-09-08
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07D249/04 , A61K45/06 , A61K31/4192 , A61K47/48 , C07K16/30 , C07K16/44
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/48023 , A61K47/48092 , A61K47/481 , A61K47/4833 , A61K47/48653 , A61K47/48723 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
摘要翻译： 本发明涉及用于向癌细胞，特别是前列腺癌细胞或转移前列腺癌细胞募集抗体的嵌合化合物。 根据本发明的化合物包含通过接头和任选的连接体分子共价键合到细胞结合末端（CBT）的抗体结合末端（ABT）部分。
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公开(公告)号：US11725064B2
公开(公告)日：2023-08-15
申请号：US17322124
申请日：2021-05-17
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： A61K47/54 , A61K47/68 , A61K45/06 , C07K16/44 , C07K16/30 , A61K31/4192 , C07D249/04 , A61K9/00 , A61K47/64 , A61K47/55
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US20220023428A1
公开(公告)日：2022-01-27
申请号：US17322124
申请日：2021-05-17
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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公开(公告)号：US20190127487A1
公开(公告)日：2019-05-02
申请号：US16045855
申请日：2018-07-26
申请人： YALE UNIVERSITY
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： C07K16/44 , A61K9/00 , A61K47/68 , A61K45/06 , A61K31/4192 , C07D249/04 , C07K16/30 , A61K47/54 , A61K47/55 , A61K47/64
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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