公开(公告)号：US20170283447A1

公开(公告)日：2017-10-05

申请号：US15508114

申请日：2015-09-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MILSTEIN ,  Peng HU ,  Eran FOGLER ,  Jai Anand Garg Narayana RAO

IPC: C07F15/00 ,  C07C67/40 ,  C07C29/149 ,  C07D241/08 ,  C07D207/16 ,  C07C231/08 ,  C07C213/00 ,  C07C249/02 ,  C07C227/02 ,  B01J31/24 ,  C07C231/10

CPC classification number: C07F15/0046 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/28 ,  B01J2231/641 ,  B01J2231/763 ,  B01J2531/0244 ,  B01J2531/821 ,  C07C29/149 ,  C07C67/00 ,  C07C67/40 ,  C07C209/00 ,  C07C209/50 ,  C07C213/00 ,  C07C227/02 ,  C07C231/02 ,  C07C231/08 ,  C07C231/10 ,  C07C249/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D241/08 ,  C07C69/24 ,  C07C69/78 ,  C07C69/92 ,  C07C69/708 ,  C07C69/63 ,  C07C31/125 ,  C07C31/08 ,  C07C35/08 ,  C07C31/12 ,  C07C31/20 ,  C07C31/38 ,  C07C33/22 ,  C07C33/20 ,  C07C233/36 ,  C07C237/08 ,  C07C211/10 ,  C07C215/08 ,  C07C229/08 ,  C07C229/12 ,  C07C229/56 ,  C07C233/11 ,  C07C229/14 ,  C07C233/05 ,  C07C211/03 ,  C07C229/36

Abstract: The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.