公开(公告)号：US20180214853A1

公开(公告)日：2018-08-02

申请号：US15803434

申请日：2017-11-03

Applicant: Archer-Daniels-Midland Company

Inventor： Vincent J. Murphy ,  James Shoemaker ,  Guang Zhu ,  Raymond Archer ,  George Frederick Salem ,  Eric L. Dias

IPC: B01J23/52 ,  B01J23/42 ,  B01J37/02 ,  B01J29/06 ,  B01J21/06 ,  B01J21/08 ,  B01J37/18 ,  B01J35/00 ,  C07C51/235 ,  C07C51/377 ,  C07C51/41 ,  C07C209/00 ,  C07C253/00 ,  C07D201/08 ,  C07D223/10 ,  C07D309/30 ,  C08G63/16 ,  C08G69/36 ,  C08G69/26 ,  C08G69/14 ,  C07C59/285 ,  C07C55/14 ,  C07C211/12 ,  C07C255/04

CPC classification number: B01J23/52 ,  B01J21/063 ,  B01J21/066 ,  B01J21/08 ,  B01J23/42 ,  B01J29/06 ,  B01J35/0006 ,  B01J35/0013 ,  B01J37/0211 ,  B01J37/0236 ,  B01J37/0248 ,  B01J37/18 ,  C07B2200/07 ,  C07C51/235 ,  C07C51/377 ,  C07C51/412 ,  C07C209/00 ,  C07C253/00 ,  C07D201/08 ,  C07D223/10 ,  C07D309/30 ,  C08G63/16 ,  C08G69/14 ,  C08G69/26 ,  C08G69/36 ,  Y02P20/582 ,  C07C59/285 ,  C07C55/14 ,  C07C211/12 ,  C07C255/04

Abstract: Disclosed are catalysts comprised of platinum and gold. The catalysts are generally useful for the selective oxidation of compositions comprised of a primary alcohol group and at least one secondary alcohol group wherein at least the primary alcohol group is converted to a carboxyl group. More particularly, the catalysts are supported catalysts including particles comprising gold and particles comprising platinum, wherein the molar ratio of platinum to gold is in the range of about 100:1 to about 1:4, the platinum is essentially present as Pt(0) and the platinum-containing particles are of a size in the range of about 2 to about 50 nm. Also disclosed are methods for the oxidative chemocatalytic conversion of carbohydrates to carboxylic acids or derivatives thereof. Additionally, methods are disclosed for the selective oxidation of glucose to glucaric acid or derivatives thereof using catalysts comprising platinum and gold. Further, methods are disclosed for the production of such catalysts.

公开(公告)号：US09975859B2

公开(公告)日：2018-05-22

申请号：US15009499

申请日：2016-01-28

Applicant: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA

Inventor： Ying Zhang ,  Lujiang Xu ,  Qian Yao

IPC: C07D241/12 ,  C07D207/32 ,  C07D209/08 ,  C07D213/16 ,  C10B53/02 ,  C10B57/06 ,  C07D471/04 ,  C07C209/00 ,  B01J29/76 ,  C07D207/323

CPC classification number: C07D241/12 ,  B01J29/76 ,  C07C209/00 ,  C07D207/32 ,  C07D207/323 ,  C07D209/08 ,  C07D213/16 ,  C07D471/04 ,  C10B53/02 ,  C10B57/06 ,  Y02E50/14 ,  Y02P20/145 ,  C07C211/46 ,  C07C211/47

Abstract: Provided is a method for preparing a nitrogen-containing aromatic compound through catalytic pyrolysis from organic materials. The method comprises: feeding organic materials and a catalyst into a reactor, to enable the organic material to undergo reactions in the presence of nitrogen and under heating conditions, so as to generate a reaction system flow containing one or more nitrogen-containing aromatic compounds.

公开(公告)号：US09944589B2

公开(公告)日：2018-04-17

申请号：US14650292

申请日：2013-12-03

Applicant: Istituto Europeo de Oncologia S.r.L.

Inventor： Mario Varasi ,  Paola Vianello ,  Florian Thaler ,  Paolo Trifiro′ ,  Ciro Mercurio ,  Giuseppe Meroni

IPC: C07C211/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/496 ,  C07D215/12 ,  C07D295/195 ,  C07D207/50 ,  C07D213/61 ,  C07D311/70 ,  C07D211/58 ,  C07D263/04 ,  C07D233/02 ,  C07D271/113 ,  C07C209/00 ,  C07C231/12 ,  C07C269/06 ,  C07C303/36 ,  C07D319/16 ,  C07D233/32 ,  C07D239/42 ,  C07D249/06 ,  C07D263/22 ,  C07D271/10 ,  C07D295/155 ,  C07D213/64 ,  C07D307/54 ,  C07C271/28 ,  C07C211/49 ,  C07C215/42 ,  C07C217/58 ,  C07C217/74 ,  C07C233/44 ,  C07C233/80 ,  C07C237/06 ,  C07C247/16 ,  C07C311/21

CPC classification number: C07C211/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/496 ,  C07C209/00 ,  C07C211/49 ,  C07C215/42 ,  C07C217/58 ,  C07C217/74 ,  C07C231/12 ,  C07C233/44 ,  C07C233/80 ,  C07C237/06 ,  C07C247/16 ,  C07C269/06 ,  C07C271/28 ,  C07C303/36 ,  C07C311/21 ,  C07C2601/02 ,  C07D207/50 ,  C07D211/58 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D233/02 ,  C07D233/32 ,  C07D239/42 ,  C07D249/06 ,  C07D263/04 ,  C07D263/22 ,  C07D271/10 ,  C07D271/113 ,  C07D295/155 ,  C07D295/195 ,  C07D307/54 ,  C07D311/70 ,  C07D319/16 ,  A61K2300/00

Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US09725456B2

公开(公告)日：2017-08-08

申请号：US14655781

申请日：2014-01-10

Applicant: THE CHEMOURS COMPANY FC LLC ,  TRINITY WESTERN UNIVERSITY

Inventor： Jon Lee Howell ,  Chadron Mark Friesen ,  Benson Jacob Jelier

IPC: C07D487/08 ,  C10M169/06 ,  C07D213/74 ,  C07F9/54 ,  C07C209/00 ,  C07C209/68 ,  C07C211/63 ,  C07D487/18 ,  C07D295/037 ,  C07C29/00 ,  C08G65/22 ,  C08G65/00 ,  C08G65/26

CPC classification number: C07D487/08 ,  C07C29/00 ,  C07C209/00 ,  C07C209/68 ,  C07C211/63 ,  C07D213/74 ,  C07D295/037 ,  C07D487/18 ,  C07F9/5407 ,  C08G65/007 ,  C08G65/226 ,  C08G65/2621 ,  C08G65/2624 ,  C10M169/06 ,  C07C31/40

Abstract: The present invention relates to anhydrous tetraalkyl pnictogen perfluoroalkoxy salts and a process to produce anhydrous tetraalkyl pnictogen perfluoroalkoxy salts. The process involves contacting a hydrofluoroether and an amine to produce a tetraalkyl pnictogen perfluoroalkoxy salt in the presence of a solvent. The present invention also relates to processes of preparing fluoroalkyl ether acid fluoride polymers using tetraalkyl pnictogen perfluoroalkoxy salt. The present invention further relates to some novel fluorinated alkyl polyether polymers.

公开(公告)号：US20160318931A1

公开(公告)日：2016-11-03

申请号：US15056313

申请日：2016-02-29

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Sara Hadida-Ruah ,  Anna Hazlewood ,  Peter Grootenhuis ,  Fredrick Van Goor ,  Ashvani Singh ,  Jinglan Zhou ,  Jason McCartney

IPC: C07D471/10 ,  A61K31/47 ,  A61K45/06 ,  C07D209/08 ,  A61K31/404 ,  C07D209/04 ,  C07D209/42 ,  C07D401/12 ,  A61K31/4709 ,  C07C215/76 ,  A61K31/136 ,  C07C217/84 ,  C07D311/58 ,  A61K31/352 ,  C07C205/58 ,  A61K31/265 ,  C07C217/80 ,  C07C217/76 ,  C07C211/52 ,  C07C211/50 ,  C07C311/08 ,  C07D209/96 ,  A61K31/403 ,  C07D223/16 ,  A61K31/55 ,  A61K31/4747 ,  C07D279/16 ,  A61K31/5415 ,  C07D265/36 ,  A61K31/538 ,  C07D217/04 ,  A61K31/472 ,  C07C255/58 ,  A61K31/277 ,  C07C271/20 ,  A61K31/27 ,  C07C311/39 ,  C07D213/73 ,  A61K31/44 ,  C07C205/11 ,  A61K31/04 ,  C07C215/70 ,  C07D401/14 ,  G01N33/68 ,  C07D215/56

CPC classification number: C07D471/10 ,  A61K8/4926 ,  A61K31/04 ,  A61K31/136 ,  A61K31/265 ,  A61K31/27 ,  A61K31/277 ,  A61K31/352 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4747 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  C07C205/11 ,  C07C205/58 ,  C07C209/00 ,  C07C211/17 ,  C07C211/50 ,  C07C211/52 ,  C07C215/28 ,  C07C215/70 ,  C07C215/76 ,  C07C215/78 ,  C07C217/76 ,  C07C217/80 ,  C07C217/84 ,  C07C219/34 ,  C07C229/52 ,  C07C255/58 ,  C07C271/20 ,  C07C311/08 ,  C07C311/39 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2603/74 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/20 ,  C07D209/42 ,  C07D209/94 ,  C07D209/96 ,  C07D213/20 ,  C07D213/73 ,  C07D215/227 ,  C07D215/233 ,  C07D215/38 ,  C07D215/56 ,  C07D217/04 ,  C07D217/06 ,  C07D223/16 ,  C07D265/36 ,  C07D279/16 ,  C07D311/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  G01N33/48728 ,  G01N33/5035 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/705

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：US09440991B2

公开(公告)日：2016-09-13

申请号：US14576143

申请日：2014-12-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Amy Cagulada ,  Johann Chan ,  Lina Chan ,  Denise A. Colby ,  Kapil Kumar Karki ,  Darryl Kato ,  Katie Ann Keaton ,  Sudha Kondapally ,  Chris Levins ,  Adam Littke ,  Ruben Martinez ,  Dominika Pcion ,  Troy Reynolds ,  Bruce Ross ,  Michael Sangi ,  Adam J. Schrier ,  Pamela Seng ,  Dustin Siegel ,  Nathan Shapiro ,  Donald Tang ,  James G. Taylor ,  Jonathan Tripp ,  Andrew W. Waltman ,  Lawrence Yu

IPC: C07D403/12 ,  C07D413/14 ,  C07D498/16 ,  C07C227/02 ,  C07D453/02 ,  C07C209/00 ,  C07C51/09 ,  C07K5/083

CPC classification number: C07D498/18 ,  C07C51/09 ,  C07C205/57 ,  C07C209/00 ,  C07C227/02 ,  C07C233/09 ,  C07C251/12 ,  C07C255/61 ,  C07C271/34 ,  C07C2601/02 ,  C07D241/44 ,  C07D403/12 ,  C07D453/02 ,  C07D498/16 ,  C07K5/0808

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

公开(公告)号：US09440908B2

公开(公告)日：2016-09-13

申请号：US14396570

申请日：2013-04-25

Applicant: BAYER CROPSCIENCE AG

Inventor： Thomas Himmler ,  Sandra Lehmann ,  Thomas Norbert Muller ,  Mathias Riedrich ,  Lars Rodefeld ,  Frank Volz ,  Sascha Von Morgenstern

IPC: C07C211/40 ,  C07C209/26 ,  C07C17/093 ,  C07C25/06 ,  C07C45/00 ,  C07C201/12 ,  C07C209/00 ,  C07C209/36 ,  C07C209/70 ,  C07C245/20 ,  C07C249/02 ,  C07F3/02

CPC classification number: C07C211/40 ,  C07C17/093 ,  C07C25/06 ,  C07C45/004 ,  C07C201/12 ,  C07C209/00 ,  C07C209/26 ,  C07C209/365 ,  C07C209/70 ,  C07C245/20 ,  C07C249/02 ,  C07C2601/02 ,  C07F3/02 ,  Y10S585/931 ,  C07C47/55 ,  C07C211/52 ,  C07C251/24 ,  C07C209/68 ,  C07C251/04 ,  C07C209/52 ,  C07C25/02 ,  C07C205/06

Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.

Abstract translation: 本发明涉及通过在特定的铂催化剂上氢化N - [（5-氯-2-异丙基苯基）亚甲基]环丙胺而制备N-（5-氯-2-异丙基苄基）环丙胺的方法。

公开(公告)号：US09434709B2

公开(公告)日：2016-09-06

申请号：US14854780

申请日：2015-09-15

Applicant: Rennovia Inc.

Inventor： Thomas R. Boussie ,  Eric L. Dias ,  Zachary M. Fresco ,  Vincent J. Murphy ,  James Shoemaker ,  Raymond Archer ,  Hong Jiang

IPC: C07C51/36 ,  C07C51/31 ,  C07D309/30 ,  B01J23/40 ,  B01J23/44 ,  B01J23/46 ,  B01J23/52 ,  B01J23/652 ,  B01J23/656 ,  B01J23/89 ,  B01J35/00 ,  B01J37/02 ,  C07C51/235 ,  C07C51/377 ,  C07C51/41 ,  C07C209/00 ,  C07C253/00 ,  C07D201/08 ,  C07D223/10 ,  C08G63/16 ,  C08G69/14 ,  C08G69/26 ,  C08G69/36 ,  C07C201/08 ,  B01J21/06 ,  B01J21/08 ,  B01J21/16 ,  B01J21/18

CPC classification number: C07C51/377 ,  B01J21/063 ,  B01J21/066 ,  B01J21/08 ,  B01J21/16 ,  B01J21/18 ,  B01J23/40 ,  B01J23/44 ,  B01J23/462 ,  B01J23/464 ,  B01J23/468 ,  B01J23/52 ,  B01J23/6525 ,  B01J23/6562 ,  B01J23/6567 ,  B01J23/8906 ,  B01J23/8913 ,  B01J23/8926 ,  B01J35/006 ,  B01J37/0205 ,  C07B2200/07 ,  C07C51/235 ,  C07C51/31 ,  C07C51/412 ,  C07C201/08 ,  C07C209/00 ,  C07C253/00 ,  C07D201/08 ,  C07D223/10 ,  C07D309/30 ,  C08G63/16 ,  C08G69/14 ,  C08G69/26 ,  C08G69/36 ,  Y02P20/582 ,  C07C55/14 ,  C07C211/12 ,  C07C255/04

Abstract: The present invention generally relates to processes for the chemocatalytic conversion of a glucose source to an adipic acid product. The present invention includes processes for the conversion of glucose to an adipic acid product via glucaric acid or derivatives thereof. The present invention also includes processes comprising catalytic oxidation of glucose to glucaric acid or derivative thereof and processes comprising the catalytic hydrodeoxygenation of glucaric acid or derivatives thereof to an adipic acid product. The present invention also includes products produced from adipic acid product and processes for the production thereof from such adipic acid product.

公开(公告)号：US20160145217A1

公开(公告)日：2016-05-26

申请号：US15009499

申请日：2016-01-28

Applicant: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA

Inventor： Ying Zhang ,  Lujiang Xu ,  Qian Yao

IPC: C07D241/12 ,  C07C209/00 ,  C07D209/08 ,  C07D213/16 ,  C07D207/323

CPC classification number: C07D241/12 ,  B01J29/76 ,  C07C209/00 ,  C07D207/32 ,  C07D207/323 ,  C07D209/08 ,  C07D213/16 ,  C07D471/04 ,  C10B53/02 ,  C10B57/06 ,  Y02E50/14 ,  Y02P20/145 ,  C07C211/46 ,  C07C211/47

Abstract: Provided is a method for preparing a nitrogen-containing aromatic compound through catalytic pyrolysis from organic materials. The method comprises: feeding organic materials and a catalyst into a reactor, to enable the organic material to undergo reactions in the presence of nitrogen and under heating conditions, so as to generate a reaction system flow containing one or more nitrogen-containing aromatic compounds.

Abstract translation: 提供了通过有机材料的催化热解制备含氮芳族化合物的方法。 该方法包括：将有机材料和催化剂进料到反应器中，使有机材料在氮气和加热条件下进行反应，以产生含有一种或多种含氮芳族化合物的反应体系流。

公开(公告)号：US09346772B2

公开(公告)日：2016-05-24

申请号：US14823682

申请日：2015-08-11

Applicant: Sogang University Research Foundation

Inventor： Nam Hwi Hur ,  Byeong No Lee

IPC: C07D295/13 ,  C07B43/00 ,  C07C269/04 ,  C07C249/02 ,  C07C209/62 ,  C07C209/46 ,  C07C209/00

CPC classification number: C07D295/13 ,  C07B43/00 ,  C07C209/00 ,  C07C209/46 ,  C07C209/62 ,  C07C249/02 ,  C07C269/04 ,  C07C271/02 ,  C07C211/05 ,  C07C251/24

Abstract: The present application relates to a preparation method for solid powder of a carbamic acid derivative, which includes reacting an amine derivative with carbon dioxide at a temperature in a range of from about −30° C. to about 500° C. and at a pressure in a range of from about 0.3 MPa to about 100 MPa. In addition, the present disclosure relates to a reduction method for solid powder of a carbamic acid derivative to an amine derivative and carbon dioxide, which includes dissolving solid powder of the carbamic acid derivative prepared in a solvent; refluxing the carbamic acid derivative at a temperature in a range of from about 30° C. to about 100° C.; and evaporating the solvent.

Abstract translation: 本申请涉及氨基甲酸衍生物的固体粉末的制备方法，其包括使胺衍生物与二氧化碳在约-30℃至约500℃的温度和压力下反应 在约0.3MPa至约100MPa的范围内。 此外，本公开涉及氨基甲酸衍生物与胺衍生物和二氧化碳的固体粉末的还原方法，其包括溶解在溶剂中制备的氨基甲酸衍生物的固体粉末; 在约30℃至约100℃的温度下回流氨基甲酸衍生物; 并蒸发溶剂。