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1.发明申请DOT1 HISTONE METHYLTRANSFERASES AS A TARGET FOR IDENTIFYING THERAPEUTIC AGENTS FOR LEUKEMIA 有权DOT1组蛋白甲基转移酶作为鉴定白喉病治疗药物的目标公开(公告)号：US20090269751A1
公开(公告)日：2009-10-29
申请号：US12251037
申请日：2008-10-14
申请人： YI ZHANG , QIN FENG , YUKI OKADA , GUOLIANG XU
发明人： YI ZHANG , QIN FENG , YUKI OKADA , GUOLIANG XU
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要翻译： 本发明提供具有组蛋白H3赖氨酸79甲基转移酶活性的多肽以及编码其的核酸。 还提供了使用本发明的多肽和核酸在筛选测定中鉴定目的化合物的方法。 还提供了用于预测受试者疾病进程的白血病和预后方法的诊断方法。
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2.发明申请DOT1 HISTONE METHYLTRANSFERASES AS A TARGET FOR IDENTIFYING THERAPEUTIC AGENTS FOR LEUKEMIA 有权DOT1组蛋白甲基转移酶作为鉴定白喉病治疗药物的目标公开(公告)号：US20100151453A1
公开(公告)日：2010-06-17
申请号：US12251078
申请日：2008-10-14
申请人： YI ZHANG , QIN FENG , YUKI OKADA , GUOLIANG XU
发明人： YI ZHANG , QIN FENG , YUKI OKADA , GUOLIANG XU
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要翻译： 本发明提供具有组蛋白H3赖氨酸79甲基转移酶活性的多肽以及编码其的核酸。 还提供了使用本发明的多肽和核酸在筛选测定中鉴定目的化合物的方法。 还提供了用于预测受试者疾病进程的白血病和预后方法的诊断方法。
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