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公开(公告)号：US20160031835A1
公开(公告)日：2016-02-04
申请号：US14811503
申请日：2015-07-28
发明人： Christopher John Burns , Andrew Frederick Wilks , Michael Francis Harte , Harrison Sikanyika , Emmanuelle Fantino
IPC分类号： C07D253/07
CPC分类号： C07D253/07 , C07D213/74 , C07D239/42 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).
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公开(公告)号：US20210309615A1
公开(公告)日：2021-10-07
申请号：US14960710
申请日：2015-12-07
发明人： Christopher John Burns , Andrew Craig Donohue , John Thomas Feutrill , Thao Lien Thi Nguyen , Andrew Frederick Wilks , Jun Zeng
IPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D401/14
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
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