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公开(公告)号：US20240132471A1
公开(公告)日：2024-04-25
申请号：US18524678
申请日：2023-11-30
发明人： Lea Aurelie BOUCHE , Wolfgang GUBA , Georg JAESCHKE , Stefanie Katharina MESCH , Angélique PATINY-ADAM , Christian SCHNIDER , Sandra STEINER , Andreas Michael TOSSTORFF
IPC分类号： C07D401/12 , C07D253/07 , C07D405/14 , C07D471/04
CPC分类号： C07D401/12 , C07D253/07 , C07D405/14 , C07D471/04
摘要： The invention relates to novel compounds having the general formula Ib
wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.-
![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/abs-image/US/2022/09/27/US11452726B2/abs.jpg.150x150.jpg)
公开(公告)号：US11452726B2
公开(公告)日：2022-09-27
申请号：US17014414
申请日：2020-09-08
发明人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
IPC分类号： C07D253/07 , A61K31/53 , C07D401/10 , C07D487/04
摘要： The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
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公开(公告)号：US20190330165A1
公开(公告)日：2019-10-31
申请号：US16397345
申请日：2019-04-29
IPC分类号： C07D253/07 , C07D253/06 , A61K45/06 , A61K31/53 , C07D403/06 , C07D417/06 , C07D413/06
摘要： This invention is directed to compositions, methods and kits that can be used for reducing cell viability, inducing cell apoptosis, and inhibiting cell proliferation, such as for the treatment of cancer. The invention is also directed to compositions, methods and kits that can be used for treating inflammatory conditions, such as by modulating inflammatory cytokines.
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4.发明申请公开(公告)号：US20190230927A1
公开(公告)日：2019-08-01
申请号：US16312095
申请日：2017-06-19
发明人： Harald JAKOBI , Klemens MINN , Estella BUSCATÓ ARSEQUELL , Hansjörg DIETRICH , Elmar GATZWEILER , Christopher Hugh ROSINGER , Anu Bheemaiah MACHETTIRA
IPC分类号： A01N43/707 , C07D253/07 , C07D253/075
摘要： The invention relates to compounds of general formula (I), to the agrochemically compatible salts thereof, to a method for the production thereof and to the use thereof in the field of plant protection.
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公开(公告)号：US10202399B2
公开(公告)日：2019-02-12
申请号：US15388267
申请日：2016-12-22
发明人： Takeshi Hondo , Keita Nakanishi , Tatsuya Niimi , Masaichi Warizaya , Ichiji Namatame , Katsuya Harada
IPC分类号： C07D213/69 , A61K31/44 , C07D491/056 , C07D403/12 , C07D401/14 , C07D405/14 , A61K31/4412 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/5377 , A61K31/551 , C07D401/06 , C07D401/12 , C07D237/16 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D253/07 , C07D401/10 , C07D405/10 , C07D413/14
摘要： Provided is a compound having a D-amino acid oxidase (DAAO) inhibitory action, and useful as, for example, a prophylaxis and/or therapeutic agent for schizophrenia or neuropathic pain. The present inventors have studied a compound that inhibits DAAO, and confirm that a dihydroxy aromatic heterocyclic compound has a DAAO inhibitory action, and completed the present invention. That is, the dihydroxy aromatic heterocyclic compound of the present invention has a good DAAO inhibitory action, and can be used as a prophylaxis and/or therapeutic agent for, for example, schizophrenia or neuropathic pain.
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公开(公告)号：US10053433B2
公开(公告)日：2018-08-21
申请号：US15382942
申请日：2016-12-19
IPC分类号： C07D213/74 , C07D239/42 , C07D241/26 , A61K31/44 , A61K31/495 , C07D257/08 , C07K14/72 , C07D213/84 , C07D237/24 , C07D253/07
CPC分类号： C07D257/08 , C07D213/74 , C07D213/84 , C07D213/85 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/26 , C07D253/07 , C07K14/721
摘要： Disclosed herein are compositions and methods for modulating the androgen receptor.
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公开(公告)号：US09862691B2
公开(公告)日：2018-01-09
申请号：US15201885
申请日：2016-07-05
IPC分类号： A61K31/53 , C07D253/075 , C07D405/04 , C07D253/06 , C07D253/08 , C07D253/07 , C07D253/10 , C07D401/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12
CPC分类号： C07D253/075 , C07D253/06 , C07D253/07 , C07D253/10 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12
摘要： A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): Each of A, N*, X, Y, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
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8.发明申请公开(公告)号：US20170339961A1
公开(公告)日：2017-11-30
申请号：US15679415
申请日：2017-08-17
申请人： Dow AgroSciences LLC
发明人： Ronald J. Heemstra , Ronald Ross, JR. , Kyle A. DeKorver , Kaitlyn Gray , Daniel I. Knueppel , Peter Vednor , Timothy P. Martin , Joseph D. Eckelbarger , John F. Daeuble, SR. , Ricky Hunter , David A. Demeter , Tony K. Trullinger , Erich W. Baum , Zoltan L. Benko , Nakyen Choy , Gary D. Crouse , Fangzheng Li , Jeffrey Nissen , Monica B. Olson , Michelle Riener , Thomas C. Sparks , Frank J. Wessels , Maurice C. Yap
IPC分类号： A01N53/00 , C07D487/04 , C07D333/60 , C07D333/48 , C07D333/36 , C07D331/04 , C07D309/14 , C07D307/52 , C07D307/33 , C07D305/08 , C07D295/32 , C07D285/06 , C07D277/36 , C07D277/30 , C07D263/26 , C07D261/12 , C07D253/07 , C07D249/08 , C07D241/20 , C07D235/30 , C07D233/80 , C07D233/36 , C07D231/56 , C07D231/12 , C07D215/38 , C07D215/227 , C07D213/89 , C07D213/84 , C07D213/81 , C07D213/75 , C07D213/56 , C07D209/49 , C07D207/452 , C07D207/273 , C07D207/10 , C07D205/04 , C07C381/10 , C07C331/12 , C07C323/59 , C07C323/42 , C07C323/41 , C07C317/50 , C07C317/40 , C07C317/28 , C07C317/14 , C07C311/46 , C07C311/08 , C07C271/66 , C07C271/28 , C07C259/10 , C07C255/60 , C07C255/57 , C07C255/46 , C07C255/29 , C07C237/42 , C07C237/22 , C07C233/65 , C07C233/63 , A01N43/90 , A01N43/82 , A01N43/707 , A01N43/653 , A01N43/60 , A01N43/40 , A01N41/10 , A01N37/34 , A01N37/22 , C07C2601/14 , C07C2601/08 , C07C2601/02 , C07C2601/04
CPC分类号： A01N53/00 , A01N37/22 , A01N37/34 , A01N41/10 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/707 , A01N43/82 , A01N43/90 , C07C233/63 , C07C233/65 , C07C237/22 , C07C237/42 , C07C255/29 , C07C255/46 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/28 , C07C271/66 , C07C311/08 , C07C311/46 , C07C317/14 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07C331/12 , C07C381/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/273 , C07D207/452 , C07D209/49 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/227 , C07D215/38 , C07D231/12 , C07D231/56 , C07D233/36 , C07D233/80 , C07D235/30 , C07D241/20 , C07D249/08 , C07D253/07 , C07D261/12 , C07D263/26 , C07D277/30 , C07D277/36 , C07D285/06 , C07D295/32 , C07D305/08 , C07D307/33 , C07D307/52 , C07D309/14 , C07D331/04 , C07D333/36 , C07D333/48 , C07D333/60 , C07D487/04
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
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公开(公告)号：US09708309B2
公开(公告)日：2017-07-18
申请号：US14848649
申请日：2015-09-09
申请人： Oryzon Genomics S.A.
发明人： Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Iñigo Tirapu Fernandez De La Cuesta , Maria de los Ángeles Estiarte-Martinez
IPC分类号： C07D239/02 , C07D413/00 , C07D417/00 , A61K31/505 , A61K31/44 , C07D417/12 , A61K31/433 , A61K31/4245 , A61K31/422 , C07D213/73 , C07D237/20 , C07D239/42 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D271/07 , C07D271/113 , C07D277/40 , C07D285/12 , C07D401/12 , C07D413/12 , C07D285/135 , C07D285/08
CPC分类号： C07D417/12 , A61K31/422 , A61K31/4245 , A61K31/433 , C07D213/73 , C07D237/20 , C07D239/42 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D271/07 , C07D271/113 , C07D277/40 , C07D285/08 , C07D285/12 , C07D285/135 , C07D401/12 , C07D413/12
摘要： The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection. Thus, in one specific aspect the invention relates to formulas (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).
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公开(公告)号：US20170101384A1
公开(公告)日：2017-04-13
申请号：US15382942
申请日：2016-12-19
IPC分类号： C07D257/08 , C07D213/84 , C07D253/07 , C07D213/74 , C07D241/26 , C07D237/24 , C07K14/72 , C07D239/42
CPC分类号： C07D257/08 , C07D213/74 , C07D213/84 , C07D213/85 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/26 , C07D253/07 , C07K14/721
摘要： Disclosed herein are compositions and methods for modulating the androgen receptor.
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