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16 条记录 (耗时 0.011 秒)

    Thieno(2,3-epsilon)(1,4)diazepine compounds
    1.
    发明授权
    Thieno(2,3-epsilon)(1,4)diazepine compounds 失效
    噻吩（2,3-EPSILON）（1,4）二氮化萘化合物

    公开(公告)号：US3840558A

    公开(公告)日：1974-10-08

    申请号：US24276872

    申请日：1972-04-10

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  ARAKI K ,  TAHARA T ,  SHIROKI M

    IPC分类号： C07D495/04 ,  A61K27/00 ,  C07D65/14

    CPC分类号： C07D495/04

    摘要： 1. A THIENO(2,3-E)(1,4)DIAZEPINE COMPOUND OF THE GENERAL FORMULA:

    2-R2,3-R1,4-(X-PHENYL-),8-R-6,7-DIHYDRO-8H-THIENO(2,3-E)

    (1,4)DIAZEPINE

    WHEREIN X IS H, HALOGEN, METHYL OR METHOXY; EACH OF R1 AND R2 IS H OR C1-4 ALKYL; AND R IS H, C1-4 ALKYL OR A GROUP OF THE FORMULA -C(=Y)NHR3 WHERE Y IS OXYGEN OR SULFUR AND R3 IS C1-C4 ALKYL OR A MEMEBER SELECTED FROM THE GROUP CONSISTING OF PHENYL, CHLOROPHENYL, AND TOLYL AND A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF.

    2-amino-thieno(2,3-e)(1,4)diazepine compounds
    2.
    发明授权
    2-amino-thieno(2,3-e)(1,4)diazepine compounds 失效
    2-氨基-3-（2,3-E）（1,4）二氮杂环丁烷化合物

    公开(公告)号：US3828039A

    公开(公告)日：1974-08-06

    申请号：US24343572

    申请日：1972-04-12

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  SHIROKI M ,  TAHARA T ,  ARAKI K

    IPC分类号： C07D495/04 ,  A61K27/00 ,  C07D63/12 ,  C07D63/14

    CPC分类号： C07D495/04 ,  Y10S514/96

    摘要： 2-AMINO-THIENO(2,3-E)(1,4)DIAZEPINE COMPOUNDS OF THE GENERAL FORMULA:

    2-(R3-N(-R4)-),5-(X-PHENYL),6-R1,7-R2-THIENO(2,3-E)(1,4)

    DIAZEPINE

    WHERE X IS H, HALOGEN, METHYL, METHOXY OR TRIFLUOROMETHYL; EACH OF R1 AND R2 IS H OR C1-4 ALKYL, OR R1 AND R2 COMBINEDLY FORM -(CH2)4-; AND -N(R3) (R4) IS AMINO, ALKYL- OR DIALKYL-AMINO (ALKYL BEING C1-4 ALKYL), 1PYRROLIDINYL, PIPERIDINO, MORPHOLINO OR 4-METHYL-1-PIPERAZINYL; AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, ARE USEFUL AS PSYCHOTRIPICS.

    4-aryl alkyl piperazino thienobenzo thiazepines
    3.
    发明授权
    4-aryl alkyl piperazino thienobenzo thiazepines 失效
    4-ARYL ALKYL PIPERAZINO THIENOBENZO THIAZEPINES

    公开(公告)号：US3813395A

    公开(公告)日：1974-05-28

    申请号：US14317971

    申请日：1971-05-13

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  MUNAKATA T ,  SETOGUCHI S ,  FUKUNARI S

    IPC分类号： C07D513/04 ,  C07D51/70

    CPC分类号： C07D513/04 ,  Y10S514/96

    摘要： A THIENOBENZOTHIAZEPINE COMPOUND OF THE FORMULA

    2,3-(-X-),4-(4-(AR-(CH2)N-)PIPERAZINO)-1,5-BENZOTHIAZEPINE

    WHEREIN AR IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF A PHENYL, PYRIDYL AND THIENTYL GROUP; N IS 1 OR 2; AND X IS A THIOPHENE RING, THE CONDENSED RING SYSTEM CONTAINING SAID THIOPENE RING BEING A MEMBER SELECTED FROM THE GROUP CONSISTING OF THIENO(2,3-B)(1,5)BENZOTHIAZEPINE AND A THIENO(2,3-B)(1,5)BENZOTHIAZEPINE; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE PRESENT INVENTION ALSO EXTENDS TO A PROCESS FOR MAKING THE AFOREMENTIONED COMPOUNDS, A PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUNDS AND A METHOD FOR TREATING PSYCHO DISORDERS BY EMPLOYING SAID COMPOUND.

    2-amino-3-pyridylcarbonylthiophene compounds
    4.
    发明授权
    2-amino-3-pyridylcarbonylthiophene compounds 失效
    2-氨基-3-吡啶基二苯甲酮化合物

    公开(公告)号：US3806512A

    公开(公告)日：1974-04-23

    申请号：US27558472

    申请日：1972-07-27

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  ARAKI K ,  SHIROKI M ,  TAHARA T

    IPC分类号： C07D495/04 ,  C07D31/50

    CPC分类号： C07D495/04 ,  Y10S514/825 ,  Y10S514/96

    摘要： 2-AMINO-3-PYRIDYLCARBONYLTHIOPHENYL COMPOUND OF THE GENERAL FORMULA:

    2-(R3-NH-),3-(PYRIDYL-CO-),4-R1,5-R2-THIOPHENE

    WHEREIN EACH OF R1, R2 AND R3 IS H C1-4 ALKYL SUCH AS METHYL, ETHYL PROPYL, BUTYL OR ISOBUTYL, OR R1 ANS R2 COMBINEDLY FROM -(CH2)4-; 5-PYRIDLY-THIENO(2,3-E) (1,4)DIAZEPIN-2-ONE COMPOUNDS OF THE FORMULA:

    1-R3,5-PYRIDYL,6-R4,7-R5-2,3-DIHYDRO-1H-THIENO(2,3-E)-

    1,4-DIAZEPIN-2-ONE

    WHEREIN EACH OF R3, R4 AND R5 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF H AND A LOWER ALKYL GROUPOF FROM 1 TO 4 CARBON ATOMS; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE COMPOUNDS OF THE FORMULA I ARE USEFUL AS ANALGESIC-ANTI-INFLAMMATORY AGENTS, AND THE COMPOUND OF THE FORMULA II ARE USEFUL AS ANTICONVULSANTS.

    1-oxa-2,4,8-triazaspiro(4,5)dec-2-enes
    5.
    发明授权
    1-oxa-2,4,8-triazaspiro(4,5)dec-2-enes 失效
    1-OXA-2,4,8-TRIAZASPIRO（4,5）DEC-2-ENES

    公开(公告)号：US3790579A

    公开(公告)日：1974-02-05

    申请号：US3790579D

    申请日：1971-08-19

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： AO H ,  NAKANISHI M ,  ARIMURA K

    IPC分类号： C07D498/10 ,  C07D85/52

    CPC分类号： C07D498/10 ,  Y10S514/929

    摘要： 1-OXA-2,4,8-TRIAZASPIRO(4,5z)DEC-2-ENES OF THE FORMULA:

    8-((R1-1,4-BENZODIOXAN-2-YL)-CH2-)-1-OXA-2,4,8-TRIAZA

    SPIRO(4.5)DEC-2-ENE

    AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, WHEREIN R1 IS H, CL, CH3 OR OCH3; AND R2 IS AN ALKYL GROUP OF FROM 1 TO 3 CARBON ATOMS, A BENZYL GROUP, A PHENYL GROUP AND A SUBSTITUTED PHENYL GROUP IN WHICH THE SUBSTITUENT IS SELECTED FROM THE GROUP CONSISTING OF CL, CH3 AND OCH3, THSE COMPOUNDS ARE USEFUL AS VASODILATORS AND CAN BE PREPARED BY REACTING A FUNCTIONAL DERIVATIVE OF THE CORRESPONDING BENZODIOXANYLMETHANOL WITH THE CORRESPONDING NEW OXATROAZASPIRODECENE.

    2-oxo-1,4-dioxa-8-azaspiro (4.5) decanes and related compounds
    7.
    发明授权
    2-oxo-1,4-dioxa-8-azaspiro (4.5) decanes and related compounds 失效
    2-OXO-1,4-DIOXA-8-AZASPIRO（4.5）癸烷和相关化合物

    公开(公告)号：US3784551A

    公开(公告)日：1974-01-08

    申请号：US3784551D

    申请日：1971-07-08

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  ARIMURA K ,  AO H

    IPC分类号： C07D497/10 ,  C07D99/04 ,  C07D99/06

    CPC分类号： C07D497/10

    摘要： SPIRO COMPOUNDS OF THE FORMULA

    (-CH(-R3)-(CH2)M-N(-R4)-(CH2)N-)>C
    WHEREIN EACH OF R1 AND R2 IS H, CH3 C2H5, PHENYL, PCHLOROPHENYL OR BENZYL; X IS O OR S; R3 IS H AND R4 IS H, ALKYL OF 1 TO 4 CARBON ATOMS, METHOXYCARBONYL, ETHOXYCARBONYL, ACETYL BENZOLYL, BENZYL, PHENETHYL, PYRIDYLMETHYL, PYRIDYLETHYL, FURFURYL, THENYL, CINNAMYL, CINNAMOYL, ALLYL OR PROPARGYL, AND M PLUS N IS 2 OR 3 (M BEING 0 OR 1 AND N BEING 2 OR 3); OR R3 AND R4 COMBINEDLY REPRESENT :CH2-CH3-, M IS 2 AND N IS 1, AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION AND QUATERNARY AMNONIUM SALTS THEREOF ARE USEFUL AS ACETYLCHLORINE ANTAGONISTIC AGENTS AND GASTRIC JUICE SECRETION INHIBITING AGENTS.

    N substituted piperidine compounds
    9.
    发明授权
    N substituted piperidine compounds 失效
    N替代哌啶化合物

    公开(公告)号：US3770729A

    公开(公告)日：1973-11-06

    申请号：US3770729D

    申请日：1971-12-21

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI M ,  OE T ,  TASHIRO C

    IPC分类号： C07D498/10 ,  C07D513/10 ,  C07D29/28

    CPC分类号： C07D513/10

    摘要： IN WHICH Q IS O OR S AND R4 IS H, CH3 OR PHENYL, AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF ARE USEFUL AS PSYCHOTROPIC AGENTS FOR THE TREATMENT OF SCHIZOPHRENIA, PSYCHONEUROSIS, MANIC-DEPRESSIVE PSYCHOSIS AND THE LIKE.

    >C C
    IN WHICH R2 IS OH, CN, CONH2, COOC2H5 OR COCH3 AND R3 IS DIMETHYLAMINO, PIPERIDINO, MORPHOLINO, PHENYL SUBSTITUTED PHENYL (THE SUBSTITUENT BEING CL, CH3 OR CF3) OR ACETYLAMINO,

    >C(-R2)-R3

    WHEREIN Y IS O, S OR SO2, R1 IS H, CL, CH3 OR OCH3 AND Z IS A BIVALENT GROUP SELECTED FROM THE GROUP CONSISTING OF

    Y-(4-R1-1,2-PHENYLENE)-)

    (-(CH2)2-Z-(CH2)2-)>N-(CH2)2-CH=C
    N-SUBSTITUTED PIPERIDINE COMPOUNDS OF THE FORMULA