公开(公告)号：US3849405A

公开(公告)日：1974-11-19

申请号：US11624071

申请日：1971-02-17

申请人： YOSHITOMI PHARMACEUTICAL

发明人： SHIROKI M ,  NAKANISHI M ,  ARAKI K

IPC分类号： C07D333/36 ,  C07D333/78 ,  C07D495/04 ,  C07D53/02 ,  C07D63/18

CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D333/78

摘要： 1. THIENO-(2,3-E)(1,4) DIAZEPIN-2-ONES OF THE FORMULA-

1-R2,2-(O=),5-(2-HAL-PHENYL-),7-R1-THIENO-(2,3-E)(1,4)-

DIAZEPININE

WHEREIN R1 IS A LOWER ALKYL GROUP OF FROM 1 TO 2 CARBON ATOMS; R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF A HYDROGEN ATOM AND A METHYL GROUP; AND HAL REPRESENTS A HALOGEN ATOM; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

公开(公告)号：US3806512A

公开(公告)日：1974-04-23

申请号：US27558472

申请日：1972-07-27

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI M ,  ARAKI K ,  SHIROKI M ,  TAHARA T

IPC分类号： C07D495/04 ,  C07D31/50

CPC分类号： C07D495/04 ,  Y10S514/825 ,  Y10S514/96

摘要： 2-AMINO-3-PYRIDYLCARBONYLTHIOPHENYL COMPOUND OF THE GENERAL FORMULA:

2-(R3-NH-),3-(PYRIDYL-CO-),4-R1,5-R2-THIOPHENE

WHEREIN EACH OF R1, R2 AND R3 IS H C1-4 ALKYL SUCH AS METHYL, ETHYL PROPYL, BUTYL OR ISOBUTYL, OR R1 ANS R2 COMBINEDLY FROM -(CH2)4-; 5-PYRIDLY-THIENO(2,3-E) (1,4)DIAZEPIN-2-ONE COMPOUNDS OF THE FORMULA:

1-R3,5-PYRIDYL,6-R4,7-R5-2,3-DIHYDRO-1H-THIENO(2,3-E)-

1,4-DIAZEPIN-2-ONE

WHEREIN EACH OF R3, R4 AND R5 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF H AND A LOWER ALKYL GROUPOF FROM 1 TO 4 CARBON ATOMS; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE COMPOUNDS OF THE FORMULA I ARE USEFUL AS ANALGESIC-ANTI-INFLAMMATORY AGENTS, AND THE COMPOUND OF THE FORMULA II ARE USEFUL AS ANTICONVULSANTS.

公开(公告)号：US3840558A

公开(公告)日：1974-10-08

申请号：US24276872

申请日：1972-04-10

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI M ,  ARAKI K ,  TAHARA T ,  SHIROKI M

IPC分类号： C07D495/04 ,  A61K27/00 ,  C07D65/14

CPC分类号： C07D495/04

摘要： 1. A THIENO(2,3-E)(1,4)DIAZEPINE COMPOUND OF THE GENERAL FORMULA:

2-R2,3-R1,4-(X-PHENYL-),8-R-6,7-DIHYDRO-8H-THIENO(2,3-E)

(1,4)DIAZEPINE

WHEREIN X IS H, HALOGEN, METHYL OR METHOXY; EACH OF R1 AND R2 IS H OR C1-4 ALKYL; AND R IS H, C1-4 ALKYL OR A GROUP OF THE FORMULA -C(=Y)NHR3 WHERE Y IS OXYGEN OR SULFUR AND R3 IS C1-C4 ALKYL OR A MEMEBER SELECTED FROM THE GROUP CONSISTING OF PHENYL, CHLOROPHENYL, AND TOLYL AND A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF.

公开(公告)号：US3828039A

公开(公告)日：1974-08-06

申请号：US24343572

申请日：1972-04-12

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI M ,  SHIROKI M ,  TAHARA T ,  ARAKI K

IPC分类号： C07D495/04 ,  A61K27/00 ,  C07D63/12 ,  C07D63/14

CPC分类号： C07D495/04 ,  Y10S514/96

摘要： 2-AMINO-THIENO(2,3-E)(1,4)DIAZEPINE COMPOUNDS OF THE GENERAL FORMULA:

2-(R3-N(-R4)-),5-(X-PHENYL),6-R1,7-R2-THIENO(2,3-E)(1,4)

DIAZEPINE

WHERE X IS H, HALOGEN, METHYL, METHOXY OR TRIFLUOROMETHYL; EACH OF R1 AND R2 IS H OR C1-4 ALKYL, OR R1 AND R2 COMBINEDLY FORM -(CH2)4-; AND -N(R3) (R4) IS AMINO, ALKYL- OR DIALKYL-AMINO (ALKYL BEING C1-4 ALKYL), 1PYRROLIDINYL, PIPERIDINO, MORPHOLINO OR 4-METHYL-1-PIPERAZINYL; AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, ARE USEFUL AS PSYCHOTRIPICS.