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公开(公告)号：US20120259314A1
公开(公告)日：2012-10-11
申请号：US13083764
申请日：2011-04-11
申请人： Ya Guo , Stefan Tunev , Joseph Traina
发明人： Ya Guo , Stefan Tunev , Joseph Traina
CPC分类号： A61B17/22 , A61B2017/22038 , A61B2017/22084 , A61B2017/22094 , A61B2017/308
摘要： A method of recanalizing a chronic total occlusion (CTO) is disclosed. A catheter with a guidewire slidingly received therein is positioned proximally adjacent to the CTO. An occlusion weakening therapy effective to quickly soften and/or loosen the CTO is delivered to the CTO via the catheter. The occlusion weakening therapy includes at least one enzyme and a chelating agent which are selectively deliverable either together or separately depending on the type of material encountered by the guidewire. According to various methods, the enzyme(s) may be delivered if tissue is encountered, the chelating agent may be delivered if calcification is encountered, and both enzyme(s) and chelating agent(s) may be delivered if a fibrous cap is encountered. The distal end of the guidewire may be advanced into the CTO shortly after delivery of the occlusion weakening therapy and is manipulated through the CTO until the guidewire successfully crosses the CTO.
摘要翻译： 公开了一种再通过慢性完全闭塞（CTO）的方法。 具有滑动地容纳在其中的导丝的导管位于CTO的近侧。 有效快速软化和/或松开CTO的闭塞减弱治疗通过导管输送到CTO。 闭塞减弱治疗包括至少一种酶和螯合剂，其可以一起或分开选择性递送，这取决于导丝所遇到的材料的类型。 根据各种方法，如果遇到组织，则可以递送酶，如果遇到钙化，螯合剂可能被递送，并且如果遇到纤维帽，则可以递送两种酶和螯合剂 。 在输送阻塞减弱治疗之后，引导线的远端可以推进到CTO中，并且通过CTO被操纵直到导丝成功地穿过CTO。
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公开(公告)号：US08460745B2
公开(公告)日：2013-06-11
申请号：US12884503
申请日：2010-09-17
申请人： James Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
发明人： James Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US20120070563A1
公开(公告)日：2012-03-22
申请号：US12884596
申请日：2010-09-17
申请人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068 , A61L2300/416
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US08828474B2
公开(公告)日：2014-09-09
申请号：US12884596
申请日：2010-09-17
申请人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068 , A61L2300/416
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
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公开(公告)号：US08381774B2
公开(公告)日：2013-02-26
申请号：US12884362
申请日：2010-09-17
申请人： James Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
发明人： James Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US20110070357A1
公开(公告)日：2011-03-24
申请号：US12884503
申请日：2010-09-17
申请人： James E. Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
发明人： James E. Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
IPC分类号： B05D7/00
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US20110067778A1
公开(公告)日：2011-03-24
申请号：US12884362
申请日：2010-09-17
申请人： James E. Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
IPC分类号： B65B1/04
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
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