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公开(公告)号：US20110070357A1
公开(公告)日：2011-03-24
申请号：US12884503
申请日：2010-09-17
申请人： James E. Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
发明人： James E. Mitchell , Justin Peterson , Dishuan Chu , Joseph Traina , Salvador Avelar , Michele Silver
IPC分类号： B05D7/00
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US20120070563A1
公开(公告)日：2012-03-22
申请号：US12884596
申请日：2010-09-17
申请人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068 , A61L2300/416
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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公开(公告)号：US08828474B2
公开(公告)日：2014-09-09
申请号：US12884596
申请日：2010-09-17
申请人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , William Heaton , Dishuan Chu , Terry Morgan , Justin Peterson , Joseph Traina
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068 , A61L2300/416
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
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公开(公告)号：US20110067778A1
公开(公告)日：2011-03-24
申请号：US12884362
申请日：2010-09-17
申请人： James E. Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
发明人： James E. Mitchell , Dishuan Chu , Justin Peterson , Joseph Traina
IPC分类号： B65B1/04
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
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公开(公告)号：US20120070562A1
公开(公告)日：2012-03-22
申请号：US12884578
申请日：2010-09-17
申请人： Salvador Avelar , James E. Mitchell
发明人： Salvador Avelar , James E. Mitchell
IPC分类号： B05D3/00
CPC分类号： A61L31/16 , A61F2/86 , A61F2240/001 , A61F2250/0068 , A61L31/14 , A61L2300/416 , A61L2300/802
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。
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6.发明授权公开(公告)号：US08027756B2
公开(公告)日：2011-09-27
申请号：US11608064
申请日：2006-12-07
申请人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
发明人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
IPC分类号： G05D1/06
CPC分类号： G01C23/00 , G01C21/00 , G01C23/005 , G08G5/0021 , G08G5/025
摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.
摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。
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7.发明授权Radiation-sensitive composition containing a vinyl pyrrolidone polymer and use thereof in lithographic printing plates 失效含有乙烯基吡咯烷酮聚合物的辐射敏感性组合物及其在平版印刷版中的应用
公开(公告)号：US5061601A
公开(公告)日：1991-10-29
申请号：US554232
申请日：1990-07-17
申请人： Paul R. West , James E. Mitchell , Gary R. Miller , Paul R. Josephson, Jr. , Raymond W. Ryan, Jr.
发明人： Paul R. West , James E. Mitchell , Gary R. Miller , Paul R. Josephson, Jr. , Raymond W. Ryan, Jr.
CPC分类号： G03F7/0384 , C08L67/06
摘要： Radiation-sensitive compositions which are especially useful in the production of negative-working lithographic printing plates comprise a photocrosslinkable polymer containing the photosensitive group ##STR1## as an integral part of the polymer backbone and, in an amount sufficient to improve the properties of the composition, a polymer of vinyl pyrrolidone. The polymer of vinyl pyrrolidone improves the properties of the radiation-sensitive composition in regard to such factors as shelf life, image contrast, and developability and thereby provides a superior lithographic printing plate.
摘要翻译： 特别可用于制备负性平版印刷版的辐射敏感组合物包含含有作为聚合物主链的组成部分的光敏基团“IMAGE”的光可交联聚合物，其用量足以改善组合物的性质 ，乙烯基吡咯烷酮的聚合物。 关于诸如保质期，图像对比度和显影性的因素，乙烯基吡咯烷酮的聚合物改善了辐射敏感组合物的性能，从而提供了优异的平版印刷版。
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8.发明授权公开(公告)号：US08423207B2
公开(公告)日：2013-04-16
申请号：US13218978
申请日：2011-08-26
申请人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
发明人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
CPC分类号： G01C23/00 , G01C21/00 , G01C23/005 , G08G5/0021 , G08G5/025
摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.
摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。
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9.发明申请公开(公告)号：US20110313600A1
公开(公告)日：2011-12-22
申请号：US13218978
申请日：2011-08-26
申请人： Robert B. Davis , Daniel J. Boorman , Kirk L. Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
发明人： Robert B. Davis , Daniel J. Boorman , Kirk L. Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
CPC分类号： G01C23/00 , G01C21/00 , G01C23/005 , G08G5/0021 , G08G5/025
摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.
摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。
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10.发明申请公开(公告)号：US20080140270A1
公开(公告)日：2008-06-12
申请号：US11608064
申请日：2006-12-07
申请人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
发明人： Robert B. Davis , Daniel J. Boorman , L. Kirk Gagnon , William L. Goodman , Alan R. Jacobsen , William A. Miller , James E. Mitchell , Victor A. Riley , William F. Royce , William D. Tafs
CPC分类号： G01C23/00 , G01C21/00 , G01C23/005 , G08G5/0021 , G08G5/025
摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.
摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。
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