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1.发明申请Combination Therapy Comprising A CDK4/6 Inhibitor and a PI3K Inhibitor for Use in the Treatment of Cancer 审中-公开包含用于治疗癌症的CDK4 / 6抑制剂和PI3K抑制剂的组合疗法公开(公告)号：US20160136171A1
公开(公告)日：2016-05-19
申请号：US15003860
申请日：2016-01-22
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
摘要翻译： CDK4 / 6抑制剂与用于治疗癌症的P3Kinase抑制剂的组合。
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2.发明授权Combination therapy comprising a CDK4/6 inhibitor and a P13K inhibitor for use in the treatment of cancer 有权包含用于治疗癌症的CDK4 / 6抑制剂和P13K抑制剂的组合疗法公开(公告)号：US09271988B2
公开(公告)日：2016-03-01
申请号：US14124753
申请日：2012-07-02
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/519 , A61K31/5377 , C07D487/02 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
摘要翻译： CDK4 / 6抑制剂与用于治疗癌症的P3Kinase抑制剂的组合。
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公开(公告)号：US10010552B2
公开(公告)日：2018-07-03
申请号：US15003860
申请日：2016-01-22
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/519 , C07D487/02 , A61K31/4439 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
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公开(公告)号：US20160184311A1
公开(公告)日：2016-06-30
申请号：US14911160
申请日：2014-08-07
申请人： Yan Chen , Xizhong Huang , Sunkyu Kim
发明人： Yan Chen , Xizhong Huang , Sunkyu Kim
IPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K31/138 , A61K31/565 , A61K31/5685 , A61K31/551 , A61K31/4196 , A61K31/436
CPC分类号： A61K31/519 , A61K31/138 , A61K31/4196 , A61K31/436 , A61K31/4439 , A61K31/5377 , A61K31/551 , A61K31/5513 , A61K31/565 , A61K31/5685 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.
摘要翻译： 本公开涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，和（2）第二药剂，其是抗激素剂或其药学上可接受的盐。 本公开还涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，（2）第二药剂，其是抗激素剂或其药学上可接受的盐，和 3）作为调节PI3K / Akt / mTOR途径的药剂的第三药剂或其药学上可接受的盐。
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5.发明申请Combination Therapy Comprising A CDK4/6 Inhibitor and a P13K Inhibitor for Use in the Treatment of Cancer 有权包含用于治疗癌症的CDK4 / 6抑制剂和P13K抑制剂的组合疗法公开(公告)号：US20140107114A1
公开(公告)日：2014-04-17
申请号：US14124753
申请日：2012-07-02
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/519
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
摘要翻译： CDK4 / 6抑制剂与用于治疗癌症的P3Kinase抑制剂的组合。
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公开(公告)号：US20150322528A1
公开(公告)日：2015-11-12
申请号：US14408893
申请日：2013-06-26
申请人： Giordano Caponigro , Scott Delach , Levi Garraway , Zainab Jagani , Sunkyu Kim , Gregory Kryukov
发明人： Giordano Caponigro , Scott Delach , Levi Garraway , Zainab Jagani , Sunkyu Kim , Gregory Kryukov
IPC分类号： C12Q1/68 , A61K31/506 , A61K31/519 , A61K31/454 , G01N33/574 , G01N33/50
CPC分类号： C12Q1/6886 , A61K31/454 , A61K31/506 , A61K31/519 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/5011 , G01N33/57496 , G01N2333/4739 , G01N2440/14 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Cyclin Dependent kinase inhibitors (CDKi), methods of determining the sensitivity of a cell to a CDKi, methods of treating a patient with a CDKi and methods of screening for candidate CDKi.
摘要翻译： 本发明提供了监测生物标志物的差异基因表达以确定患者对细胞周期蛋白依赖性激酶抑制剂（CDKi）的敏感性的方法，确定细胞对CDKi的敏感性的方法，用CDKi治疗患者的方法和筛选候选者的方法 CDKi。
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7.发明申请1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases 审中-公开1,4-二取代的异喹啉酮衍生物作为可用于治疗增殖性疾病的raf-激酶抑制剂公开(公告)号：US20070060582A1
公开(公告)日：2007-03-15
申请号：US10573208
申请日：2004-09-23
申请人： Cynthia Fink , Lawrence Perez , Timothy Ramsey , Naeem Yusuff , Richard Versace , David Batt , Michael Sabio , Sunkyu Kim
发明人： Cynthia Fink , Lawrence Perez , Timothy Ramsey , Naeem Yusuff , Richard Versace , David Batt , Michael Sabio , Sunkyu Kim
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02
CPC分类号： C07D401/04 , C07D217/22 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , C07D491/10 , C07D491/113
摘要： This invention relates to compounds of the formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.
摘要翻译： 本发明涉及式（I）化合物，其中可变取代基在本文中描述。 该化合物可用于治疗以异常MAP激酶信号通路为特征的疾病，如癌症。
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公开(公告)号：US20140113909A1
公开(公告)日：2014-04-24
申请号：US14124734
申请日：2012-06-28
申请人： Sunkyu Kim , Shivang Doshi , Kristy Hans , Steven Kovats
发明人： Sunkyu Kim , Shivang Doshi , Kristy Hans , Steven Kovats
IPC分类号： A61K31/519 , A61K31/506
CPC分类号： A61K31/519 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and an FGFR kinase inhibitor for the treatment of cancer.
摘要翻译： 用于治疗癌症的CDK4 / 6抑制剂和FGFR激酶抑制剂的组合。
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9.发明申请ANODE FOR IMPROVING STORAGE PERFORMANCE AT A HIGH TEMPERATURE AND LITHIUM SECONDARY BATTERY COMPRISING THE SAME 有权用于提高包含其中的高温和锂二次电池的储存性能的阳极公开(公告)号：US20100159327A1
公开(公告)日：2010-06-24
申请号：US12309708
申请日：2007-07-21
申请人： Yun-Ho Lee , Sunkyu Kim , Seungdon Choi
发明人： Yun-Ho Lee , Sunkyu Kim , Seungdon Choi
CPC分类号： H01M4/505 , H01M4/133 , H01M4/485 , H01M4/62 , H01M4/621 , H01M4/622 , H01M10/0525 , H01M10/4235 , H01M2004/027
摘要： Provided are an anode for a battery comprising: (a) an anode active material, (b) TiO2, and (c) a styrene-butadiene rubber (SBR), and a lithium secondary battery comprising the same. By using titanium oxide and SBR together with an anode active material as the anode components in the present invention, increase in the anode resistivity during the high-temperature storage and reduction in the battery capacity by the resistivity are inhibited, thereby the overall performances of the battery can be improved.
摘要翻译： 提供一种用于电池的阳极，包括：（a）负极活性材料，（b）TiO 2和（c）苯乙烯 - 丁二烯橡胶（SBR）和包含该阳极的锂二次电池。 通过在本发明中通过使用氧化钛和SBR与阳极活性材料一起作为阳极组分，抑制了高温保存期间的阳极电阻率的增加以及电阻率降低了电池容量，因此， 电池可以改善。
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公开(公告)号：US09408847B2
公开(公告)日：2016-08-09
申请号：US14646206
申请日：2013-11-25
申请人： Shivang Doshi , Sunkyu Kim
发明人： Shivang Doshi , Sunkyu Kim
IPC分类号： A61K31/519 , A61K31/436 , A61K45/06
CPC分类号： A61K31/519 , A61K31/436 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is a mTOR inhibitor or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及药物组合，其包含（1）作为CDK抑制剂或其药学上可接受的盐的第一药剂和（2）作为mTOR抑制剂或其药学上可接受的盐的第二药剂。
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