公开(公告)号：US20100120016A1

公开(公告)日：2010-05-13

申请号：US12439462

申请日：2007-08-31

申请人： Yanbin Li ,  Billy Hargis ,  Steve Tung ,  Luc Berghman ,  Walter Bottje ,  Ronghui Wang ,  Zunzhong Ye ,  Madhukar Varshney ,  Balaji Srinivasan

发明人： Yanbin Li ,  Billy Hargis ,  Steve Tung ,  Luc Berghman ,  Walter Bottje ,  Ronghui Wang ,  Zunzhong Ye ,  Madhukar Varshney ,  Balaji Srinivasan

IPC分类号： C12Q1/70

CPC分类号： C12Q1/04 ,  C12Q1/06

摘要： An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.

摘要翻译： 一种用于检测起始材料中的污染物的阻抗生物传感器，所述生物传感器包括壳体，由壳体支撑的输入装置，由壳体支撑的输出装置，由壳体支撑的微流体单元，起始材料可与微流体接合 电池和由壳体支撑的阻抗分析仪，并可操作以测量起始材料的阻抗以检测污染物的存在。

公开(公告)号：US20210253420A1

公开(公告)日：2021-08-19

申请号：US17173839

申请日：2021-02-11

申请人： Steve Tung ,  Bo Ma ,  Ty Seiwert

发明人： Steve Tung ,  Bo Ma ,  Ty Seiwert

IPC分类号： B81C1/00 ,  B32B7/02 ,  B32B7/12 ,  C12Q1/6869 ,  B81C3/00

摘要： A method of fabricating a sensing device for DNA sequencing and biomolecule characterization including the steps of fabricating a microelectrode chip having a silicon substrate and a silicon nitride diaphragm, attaching a monolayer graphene sheet to the silicon nitride diaphragm, dicing a portion of the monolayer graphene sheet to form a graphene microribbon, converting the graphene microribbon to a graphene nanoribbon, and converting the graphene nanoribbon to a carbyne. A sensing device for DNA sequencing and biomolecule characterization is also disclosed. The sensing device includes a silicon substrate, a cavity in the silicon substrate covered by a silicon nitride layer, microelectrodes attached to the silicon nitride layer, graphene covering the microelectrodes, and carbyne attached to a portion of the silicon nitride layer covering said cavity.

公开(公告)号：US12012329B2

公开(公告)日：2024-06-18

申请号：US17173839

申请日：2021-02-11

申请人： Steve Tung ,  Bo Ma ,  Ty Seiwert

发明人： Steve Tung ,  Bo Ma ,  Ty Seiwert

IPC分类号： B81C1/00 ,  B32B7/02 ,  B32B7/12 ,  B81C3/00 ,  C12Q1/6869

CPC分类号： B81C1/00071 ,  B32B7/02 ,  B32B7/12 ,  B81C3/001 ,  C12Q1/6869

摘要： A method of fabricating a sensing device for DNA sequencing and biomolecule characterization including the steps of fabricating a microelectrode chip having a silicon substrate and a silicon nitride diaphragm, attaching a monolayer graphene sheet to the silicon nitride diaphragm, dicing a portion of the monolayer graphene sheet to form a graphene microribbon, converting the graphene microribbon to a graphene nanoribbon, and converting the graphene nanoribbon to a carbyne. A sensing device for DNA sequencing and biomolecule characterization is also disclosed. The sensing device includes a silicon substrate, a cavity in the silicon substrate covered by a silicon nitride layer, microelectrodes attached to the silicon nitride layer, graphene covering the microelectrodes, and carbyne attached to a portion of the silicon nitride layer covering said cavity.

公开(公告)号：US20220170087A1

公开(公告)日：2022-06-02

申请号：US17441094

申请日：2020-03-18

申请人： Steve TUNG ,  Bo MA ,  Board of Trustees of the University of Arkansas

发明人： Steve Tung ,  Bo Ma

IPC分类号： C12Q1/6869 ,  G01N27/04 ,  G01N33/487

摘要： A method of DNA base-calling from a nanochannel DNA sequencer. The method includes building a reference map and preparing an unknown sequence of DNA prior to the final step of data matching. The reference map includes a series of reference characters, such as numbers, that describe the change in tunneling current of a DNA strand with a known sequence. A DNA strand of unknown sequence is prepared so that the change in electrical measurement can also be described numerically. The section of match between the DNA strand of unknown sequence and the reference map is used to determine the sequence of the DNA strand.