公开(公告)号：US20090215627A1

公开(公告)日：2009-08-27

申请号：US11573217

申请日：2005-08-03

申请人： Yang Shen ,  Sandra L. Volrath ,  Stephanie C. Weatherly ,  Tedd D. Elich ,  Richard Anderson ,  Liang Tong

发明人： Yang Shen ,  Sandra L. Volrath ,  Stephanie C. Weatherly ,  Tedd D. Elich ,  Richard Anderson ,  Liang Tong

IPC分类号： A01N43/60 ,  C12N9/00 ,  A61K31/5513 ,  A01P13/00 ,  A61P3/10 ,  G06G7/48 ,  C07D243/08

CPC分类号： C12N9/93 ,  C07K2299/00

摘要： A crystal comprising a biotin carboxylase domain of acetyl-CoA carboxylase is described, along with a computer-based method for identifying compounds that modulates activity of acetyl-CoA carboxylase, a computer-based method for rationally designing a compound that modulates activity of acetyl-CoA carboxylase, along with compounds produced by such methods, as well as compositions and methods of use thereof.

摘要翻译： 描述了包含乙酰-CoA羧化酶的生物素羧化酶结构域的晶体，以及用于鉴定调节乙酰辅酶A羧化酶活性的化合物的基于计算机的方法，用于合理设计调节乙酰辅酶A羧化酶活性的化合物的基于计算机的方法， CoA羧化酶，以及通过这些方法制备的化合物，以及其组合物和使用方法。

公开(公告)号：US20140237682A1

公开(公告)日：2014-08-21

申请号：US14232897

申请日：2012-07-18

申请人： Tedd D. Elich ,  Philip N. Benfey ,  Ian Davis

发明人： Tedd D. Elich ,  Philip N. Benfey ,  Ian Davis

IPC分类号： C12N15/82

CPC分类号： C12N15/8216

摘要： The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.

摘要翻译： 本公开提供了调节植物细胞，植物组织和植物中可转录多核苷酸表达的组合物和方法。 组合物包括能够在植物组织和植物中提供表达的调节性多核苷酸分子。 还提供了使用本文公开的调节性多核苷酸分子在植物细胞，植物组织或植物中表达多核苷酸的方法。

公开(公告)号：US08816152B2

公开(公告)日：2014-08-26

申请号：US13528515

申请日：2012-06-20

申请人： Tedd D. Elich ,  Philip N. Benfey ,  Ai-Jiuan Wu ,  David A. Orlando ,  Ian Davis

发明人： Tedd D. Elich ,  Philip N. Benfey ,  Ai-Jiuan Wu ,  David A. Orlando ,  Ian Davis

IPC分类号： C12N15/113 ,  C12N15/63 ,  C12N15/82 ,  C07H21/00

CPC分类号： C12N15/8216 ,  C12N2830/65

摘要： The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.

摘要翻译： 本公开提供了用于调节植物细胞，植物组织和植物中可转录多核苷酸表达的组合物和方法。 组合物包括能够在植物组织和植物中提供表达的调节性多核苷酸分子。 还提供了使用本文公开的调节性多核苷酸分子在植物细胞，植物组织或植物中表达多核苷酸的方法。

公开(公告)号：US06723897B2

公开(公告)日：2004-04-20

申请号：US09371307

申请日：1999-08-10

申请人： Sherri M. Brown ,  Tedd D. Elich ,  Gregory R. Heck ,  Ganesh M. Kishore ,  Eugene W. Logusch ,  Sherry J. Logusch ,  Kenneth J. Piller ,  Sudabathula Rao ,  Joel E. Ream ,  Scott R. Baerson

发明人： Sherri M. Brown ,  Tedd D. Elich ,  Gregory R. Heck ,  Ganesh M. Kishore ,  Eugene W. Logusch ,  Sherry J. Logusch ,  Kenneth J. Piller ,  Sudabathula Rao ,  Joel E. Ream ,  Scott R. Baerson

IPC分类号： C12N1582

CPC分类号： C12N9/0071 ,  C12N9/00 ,  C12N9/0069 ,  C12N15/8222 ,  C12N15/8243 ,  C12N15/8297

摘要： Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase, 3-&bgr; hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing antisense RNA which suppresses the gibberellin biosynthetic pathway sequence. The antisense sequence is the complement of a copalyl diphosphate synthase sequence, a 3&bgr;-hydroxylase sequence, or a C20-oxidase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.

摘要翻译： 公开了用于抑制和控制赤霉酸水平的方法和材料。 具体地说，公开了二甲基二磷酸合成酶，3-β羟化酶和2-氧化酶的核酸序列和另外的核酸序列。 可以通过制备能够表达抑制赤霉素生物合成途径序列的反义RNA的嵌合表达构建体来抑制或控制赤霉酸水平。 反义序列是双酰基二磷酸合成酶序列，3β-羟化酶序列或C20-氧化酶序列的补体。 补充剂，优选赤霉素或赤霉素前体或中间体的施用恢复生物活性。

公开(公告)号：US20130117883A1

公开(公告)日：2013-05-09

申请号：US13808510

申请日：2011-07-07

申请人： Tedd D. Elich ,  Philip N. Benfey ,  Jee W. Jung

发明人： Tedd D. Elich ,  Philip N. Benfey ,  Jee W. Jung

IPC分类号： A01H5/00 ,  C12N15/82

CPC分类号： C12N15/8222 ,  A01H1/04 ,  C07H21/00 ,  C12N15/113 ,  C12N15/63 ,  C12N15/82 ,  C12N15/8201 ,  C12N15/8205 ,  C12N15/8216 ,  C12N15/8241 ,  C12N15/8261 ,  C12N15/8274 ,  C12N15/8286 ,  C12Q1/6895 ,  C12Q2600/158

摘要： The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.

公开(公告)号：US20120284880A1

公开(公告)日：2012-11-08

申请号：US13528515

申请日：2012-06-20

申请人： Tedd D. Elich ,  Philip N. Benfey ,  Al-Jiuan Wu ,  David A. Orlando ,  Ian Davis

发明人： Tedd D. Elich ,  Philip N. Benfey ,  Al-Jiuan Wu ,  David A. Orlando ,  Ian Davis

IPC分类号： C12N15/113 ,  C12N15/82 ,  A01H5/10 ,  C12N15/29 ,  C12N5/10 ,  A01H5/00

CPC分类号： C12N15/8216 ,  C12N2830/65

摘要： The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.

摘要翻译： 本公开提供了调节植物细胞，植物组织和植物中可转录多核苷酸表达的组合物和方法。 组合物包括能够在植物组织和植物中提供表达的调节性多核苷酸分子。 还提供了使用本文公开的调节性多核苷酸分子在植物细胞，植物组织或植物中表达多核苷酸的方法。

公开(公告)号：US11377663B1

公开(公告)日：2022-07-05

申请号：US13599254

申请日：2012-08-30

申请人： Ian W. Davis ,  Tedd D. Elich

发明人： Ian W. Davis ,  Tedd D. Elich

IPC分类号： C12N15/82

摘要： Polynucleotides comprising genetic regulatory elements, as well as constructs, host cells, and transgenic organisms comprising the same are described. The polynucleotides can control the expression of an operably linked gene in a host cell or organism, such as a plant cell or a plant. Methods of using the polynucleotide to control the expression of an operably linked gene of interest in a plant or plant cell are further provided.

公开(公告)号：US09447423B2

公开(公告)日：2016-09-20

申请号：US13808510

申请日：2011-07-07

申请人： Tedd D. Elich ,  Philip N. Benfey ,  Jee W. Jung

发明人： Tedd D. Elich ,  Philip N. Benfey ,  Jee W. Jung

IPC分类号： C12N15/82 ,  C12N15/113 ,  C12N15/63 ,  C07H21/00

CPC分类号： C12N15/8222 ,  A01H1/04 ,  C07H21/00 ,  C12N15/113 ,  C12N15/63 ,  C12N15/82 ,  C12N15/8201 ,  C12N15/8205 ,  C12N15/8216 ,  C12N15/8241 ,  C12N15/8261 ,  C12N15/8274 ,  C12N15/8286 ,  C12Q1/6895 ,  C12Q2600/158

摘要： The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.

摘要翻译： 本公开提供了用于调节植物细胞，植物组织和植物中可转录多核苷酸表达的组合物和方法。 组合物包括能够在植物组织和植物中提供表达的调节性多核苷酸分子。 还提供了使用本文公开的调节性多核苷酸分子在植物细胞，植物组织或植物中表达多核苷酸的方法。

公开(公告)号：US07195917B2

公开(公告)日：2007-03-27

申请号：US10401321

申请日：2003-03-27

申请人： Sherri M. Brown ,  Tedd D. Elich ,  Gregory R. Heck ,  Ganesh M. Kishore ,  Eugene W. Logusch ,  Sherry J. Logusch ,  Kenneth J. Piller ,  Sudabathula Rao ,  Joel E. Ream ,  Scott R. Baerson

发明人： Sherri M. Brown ,  Tedd D. Elich ,  Gregory R. Heck ,  Ganesh M. Kishore ,  Eugene W. Logusch ,  Sherry J. Logusch ,  Kenneth J. Piller ,  Sudabathula Rao ,  Joel E. Ream ,  Scott R. Baerson

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N5/10

CPC分类号： C12N9/0071 ,  C12N9/00 ,  C12N9/0069 ,  C12N15/8222 ,  C12N15/8243 ,  C12N15/8297

摘要： Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase. 3-β hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3β-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2β,3β-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.

摘要翻译： 公开了用于抑制和控制赤霉酸水平的方法和材料。 具体地，涉及椰油二磷酸合成酶的核酸序列。 3-β羟化酶和2-氧化酶和另外的核酸序列。 通过制备能够表达抑制赤霉素生物合成途径序列的RNA或蛋白质产物的嵌合表达构建体可以抑制或控制赤霉酸水平，从而使基质从途径转移或降解途径底物或产物。 该序列优选为双酰基二磷酸合成酶序列，3β-羟化酶序列，2-氧化酶序列，八氢番茄红素合成酶序列，C20-氧化酶序列和2beta3β-羟化酶序列。 补充剂，优选赤霉素或赤霉素前体或中间体的施用恢复生物活性。