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13 条记录 (耗时 0.031 秒)

    Parallel-connected uninterrupted power supply circuit
    1.
    发明授权
    Parallel-connected uninterrupted power supply circuit 有权
    并联不间断电源电路

    公开(公告)号：US08305779B2

    公开(公告)日：2012-11-06

    申请号：US12551042

    申请日：2009-08-31

    申请人： Yansong Lu ,  Jingtao Tan ,  Xiao Chen ,  Hao Yu ,  Jianping Ying

    发明人： Yansong Lu ,  Jingtao Tan ,  Xiao Chen ,  Hao Yu ,  Jianping Ying

    IPC分类号： H02M5/45

    CPC分类号： H02J9/062 ,  H02J2009/063 ,  Y02P80/112

    摘要： The configurations of a parallel-connected UPS circuit are provided in the present invention. The proposed circuit includes a neutral, a battery having a positive and a negative terminals, and a plurality of PFC boost converters, each of which includes a PFC circuit including an inductor having a first terminal coupled to the positive terminal and a second terminal, a rectifying bridge coupled to the second terminal of the inductor, and having a first terminal and a second terminal coupled to the negative terminal, a switch bridge having a first terminal coupled to the first terminal of the rectifying bridge and a second terminal coupled to the second terminal of the rectifying bridge, and a control switch having a first terminal and a second terminal coupled to the neutral.

    摘要翻译： 在本发明中提供并联UPS电路的配置。 所提出的电路包括中性线圈，具有正端子和负极端子的电池和多个PFC升压转换器，每个PFC升压转换器包括PFC电路，PFC电路包括具有耦合到正端子的第一端子和第二端子的电感器， 整流桥耦合到电感器的第二端子，并且具有耦合到负极端子的第一端子和第二端子，开关电桥，其具有耦合到整流桥的第一端子的第一端子和耦合到第二端子的第二端子 整流桥的端子和控制开关，其具有耦合到空档的第一端子和第二端子。

    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES
    3.
    发明申请
    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES 审中-公开
    新型合成抗氧化剂及其用途

    公开(公告)号：US20150336884A1

    公开(公告)日：2015-11-26

    申请号：US14647260

    申请日：2013-04-18

    申请人： Yansong Lu

    发明人： Yansong Lu

    IPC分类号： C07C327/06 ,  C07C327/26 ,  C07D487/04 ,  C07D213/65 ,  C07D241/24 ,  C07D239/38 ,  C07C327/48 ,  C07D213/83

    CPC分类号： C07C327/06 ,  C07C321/26 ,  C07C327/18 ,  C07C327/26 ,  C07C327/48 ,  C07D213/65 ,  C07D213/83 ,  C07D239/38 ,  C07D241/24 ,  C07D487/04

    摘要： The present invention relates to synthetic organic antioxidants of small molecules. The novel dithiol-containing compounds in this invention possess strongest possible capability as both scavenger for free radicals and antioxidant. This invention is directed to novel molecules as prodrugs of the novel dithiol-containing compounds, their rational design, their feasible preparation route by means of synthetic organic chemistry, and their potential uses in application to treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancer, diabetes, HIV, acne, cardiovascular disease, renal disease, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, pain, aging, stroke, cataract, glaucoma, age-related macular degeneration, etc.

    摘要翻译： 本发明涉及小分子的合成有机抗氧化剂。 本发明新型二硫醇化合物作为自由基和抗氧化剂的清除剂具有最强的可能性。 本发明涉及新型分子作为新二硫醇化合物的前药，其合理设计，其通过合成有机化学的可行制备途径及其在治疗和/或预防与氧化性相关的主要疾病中的潜在用途 压力，如阿尔茨海默病，帕金森病，癌症，糖尿病，艾滋病毒，痤疮，心血管疾病，肾脏疾病，高血压，高胆固醇血症，高脂血症，类风湿性关节炎，炎症，疼痛，老年，中风，白内障，青光眼，年龄相关性黄斑变性 等等

    Preparation of oxycodone from codeine
    5.
    发明授权
    Preparation of oxycodone from codeine 失效
    从可待因制备羟考酮

    公开(公告)号：US6008355A

    公开(公告)日：1999-12-28

    申请号：US116283

    申请日：1998-07-16

    申请人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    发明人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    IPC分类号： A61K20060101 ,  A61K31/485 ,  A61P25/04 ,  C07D20060101 ,  C07D489/02 ,  C07D489/08 ,  C07D471/00

    CPC分类号： C07D489/08 ,  C07D489/02

    摘要： A process is provided for preparing oxycodone from codeine comprising either:(A) the steps of(1) oxidizing codeine so as to form codeinone;(2) converting codeinone to oxycodone in a two-step-one-pot reaction: first reacting codeinone with hydrogen peroxide in water in the presence of an acid at from about 15.degree. to about 70.degree. C. to form 14-hydroxycodeinone and then catalytically hydrogenating 14-hydroxycodeinone in its original reaction mixture to form oxycodone; or(B) the steps of(1) oxydizing codeine so as to form codeinone;(2) reacting codeinone with an acylating agent so as to form codeinone dienol acylate;(3) oxidizing codeinone dienol acylate with an oxidation agent in water or a solubilizing solvent mixture in the presence of an acid at from about 15.degree. to about 70.degree. C. to form 14-hydroxycodeinone;(4) hydrogenating 14-hydroxycodeinone in its original reaction mixture to form oxycodone.

    摘要翻译： 提供了从可待因制备羟可待酮的方法，其包括：（A）步骤（1）氧化可待因以形成可待因酮; （2）将二氢可待因酮转化为两步一锅反应：首先在约15℃至约70℃的酸存在下，将卡知酮与过氧化氢在水中反应，形成14-羟可待因酮，然后 在其原始反应混合物中催化氢化14-羟可待因酮以形成羟考酮; 或（B）步骤（1）氧化可待因以形成可待因酮; （2）将代森西酮与酰化剂反应，形成可酮二酮二烯醇酰化物; （3）在约15℃至约70℃的酸存在下，用氧化剂在水或增溶溶剂混合物中氧化可待因酮二烯醇酰化物以形成14-羟可待因酮; （4）在其原始反应混合物中氢化14-羟可待因酮以形成羟考酮。

    Preparation of naltrexone from codeine and 3-benzylmorphine
    8.
    发明授权
    Preparation of naltrexone from codeine and 3-benzylmorphine 失效
    从可待因和3-苄基吗啡制备纳曲酮

    公开(公告)号：US6013796A

    公开(公告)日：2000-01-11

    申请号：US116282

    申请日：1998-07-16

    申请人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    发明人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    IPC分类号： A61K20060101 ,  A61K31/485 ,  A61P25/04 ,  C07D20060101 ,  C07D489/02 ,  C07D489/08 ,  C07D413/00 ,  C07D471/00

    CPC分类号： C07D489/08 ,  C07D489/02

    摘要： For the synthesis of 3-methylnaltrexone from codeine in this invention, codeine is converted to 6-acetylcodeine, which is N-demethylated to 6-acetylcodeine hydrochloride, followed by alkylating the nitrogen to form 17-cyclopropylmethylnorcodeine. The latter is oxidized to 17-cyclopropylmethylnorcodeinone. For the synthesis of naltrexone from morphine in this invention, morphine is converted to 3-benzylnormorphine as described above in the synthesis of noroxymorphone. 3-Benzylnormorphine is reacted with cyclopropylmethyl halide to produce 3-benzyl-17cyclopropylmethylnormorphine, a novel compound, which is oxidized to 3-benzyl-17-cyclopropylmethyl-normorphinone, a novel compound, by Swern oxidation.

    摘要翻译： 为了合成本发明可待因的3-甲基纳曲酮，将可待因转化为6-乙酰基可待因，将其N-去甲基化为6-乙酰基可待因盐酸盐，然后将氮烷基化形成17-环丙基甲基可待因。 后者被氧化成17-环丙基甲基可待因酮。 为了在本发明中从吗啡合成纳曲酮，如上所述在去甲吗啡酮的合成中，吗啡被转化为3-苄基吗啡。 3-苄基吗啡与环丙基甲基卤反应生成3-苄基-17环丙基甲基吗啡，一种新型化合物，通过Swern氧化被氧化成3-苄基-17-环丙基甲基 - 正吗啡酮，一种新型化合物。

    Preparation of 14-hydroxynormorphinones from normorphinones
    9.
    发明授权
    Preparation of 14-hydroxynormorphinones from normorphinones 失效
    从正诺酮制备14-羟基吗啡酮

    公开(公告)号：US5952495A

    公开(公告)日：1999-09-14

    申请号：US116286

    申请日：1998-07-16

    申请人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    发明人： Bao-Shan Huang ,  Yansong Lu ,  Ben-Yi Ji ,  Aris P Christodoulou

    IPC分类号： A61K20060101 ,  A61K31/485 ,  A61P25/04 ,  C07D20060101 ,  C07D489/02 ,  C07D489/08 ,  C07D413/00 ,  C07D471/00

    CPC分类号： C07D489/08 ,  C07D489/02

    摘要： A process is provided for preparing 14-hydroxynormorphinones having the formula: ##STR1## which comprises reacting normorphinones having the formula: ##STR2## wherein R is selected from the group consisting of lower alkyl of 1 to 7 carbon atoms, cycloalkyl-lower alkyl with 3-6 ring carbon atoms, benzyl and a substituted-benzyl having the formula: ##STR3## wherein Q and Q.sup.1 are individually selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, nitro, dialkylamino and cyano;R' is selected from the group consisting of R, 2-(4-morpholinyl)ethyl, benzyloxy carbonyl and R"C(O)-- wherein R" is lower alkyl of 1-4 carbon atoms;with hydrogen peroxide at a temperature of from about 15.degree. C. to about 70.degree. C. in the presence of an acid and an aqueous solvent system to solubilize the reactant for a period of time so as to form the 14-hydroxynormorphinones.

    摘要翻译： 提供了一种制备具有下式的14-羟基吗啡酮的方法：其包括使具有下式的正诺酮：其中R选自1至7个碳原子的低级烷基，具有3-6个环碳原子的环烷基 - 低级烷基 苄基和具有下式的取代的苄基：其中Q和Q 1分别选自氢，低级烷基，三氟甲基，硝基，二烷基氨基和氰基; R'选自R，2-（4-吗啉基）乙基，苄氧基羰基和R''C（O） - ，其中R“为1-4个碳原子的低级烷基; 与过氧化氢在约15℃至约70℃的温度下，在酸和水性溶剂体系的存在下，使反应物溶解一段时间，以形成14-羟基吗啡酮。