公开(公告)号：US07131828B2

公开(公告)日：2006-11-07

申请号：US10257068

申请日：2001-04-12

申请人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Satoru Hiruta

发明人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Satoru Hiruta

IPC分类号： B29C33/60 ,  B29C43/28

CPC分类号： B30B11/08 ,  B30B15/0011 ,  Y10T83/9423

摘要： A powder material application apparatus capable of applying powder material uniformly onto lower surfaces of plural upper punches, upper surfaces of plural lower punches and inner circumferences of plural dies of a tabletting machine. Powder material is applied on a material contacting surface of the lower punch by spraying powder material mixed with air from a powder material spray port for lower punch of a powder material application part for lower punch. Powder material is applied on a material contacting surface of the upper punch wherein powder material is not applied enough according to gravity by spraying powder material mixed with air from a powder material spray port for upper punch while the upper punch moves from an initial end to a terminal end of the powder material spray port for upper punch. The powder material spray port for upper punch is provided along the rotary orbit of the upper punches and is elongated more than the powder material spray port for lower punch.

摘要翻译： 一种粉末材料施加装置，其能够将粉末材料均匀地施加到多个上冲头的下表面，多个下冲头的上表面和压片机的多个模具的内周。 粉末材料通过喷射与空气混合的粉末材料施加在下冲头的材料接触表面上，粉末材料喷雾口用于下冲头的粉末材料施加部件的下冲头。 将粉末材料施加在上冲头的材料接触表面上，其中粉末材料根据重力不能充分施加，喷射与来自上冲头的粉末材料喷雾口的空气混合的粉末材料，同时上冲头从初始端移动到 粉末末端末端用于上冲头喷雾口。 上冲头的粉料喷射口沿着上冲头的旋转轨道设置，并且比用于下冲头的粉末喷射口更细。

公开(公告)号：US6155096A

公开(公告)日：2000-12-05

申请号：US161142

申请日：1998-09-25

申请人： Hideyuki Ikeda ,  Yasushi Watanabe ,  Kiyoshi Morimoto ,  Satoru Hiruta

发明人： Hideyuki Ikeda ,  Yasushi Watanabe ,  Kiyoshi Morimoto ,  Satoru Hiruta

IPC分类号： G01N15/06 ,  G01N21/59 ,  G01N21/85 ,  G01N1/00

CPC分类号： B30B15/0011 ,  B30B15/0082 ,  G01N21/85

摘要： A light transmission powder and granular material measuring apparatus for a continuous production line assembly is provided. A conduit line is capable of being connected to the production line to provide an alternative flow path for the powder and/or granular material. A light transmission cell is mounted in the conduit and a measurement apparatus is provided for measuring the light as it passes through the light transmission cell. A valve member can interconnect the conduit to the production line to control the flow of powder and/or granular material, whereby a measurement can be made when the valve is activated to permit the flow of powder and/or granular material to provide an accurate measurement, and also a measurement can be made as a reference measurement during a calibration cycle when the valve is activated to stop the flow of powder and/or granular material. The light transmission powder and/or granular material measuring apparatus can be provided as a modular unit for mounting in a continuous production line and can be automatically controlled to periodically calibrate its measurements.

摘要翻译： 提供了一种用于连续生产线组件的透光粉和颗粒材料测量装置。 导管线能够连接到生产线以为粉末和/或颗粒材料提供替代的流动路径。 光传输电池安装在导管中，并且提供测量装置用于当光通过光传输电池时测量光。 阀构件可将导管与生产线相互连接以控制粉末和/或颗粒材料的流动，从而当阀被启动以允许粉末和/或颗粒材料流动以提供准确的测量时，可进行测量 ，并且当阀被启动以停止粉末和/或颗粒材料的流动时，也可以在校准周期期间进行测量作为参考测量。 光透射粉末和/或颗粒材料测量装置可以设置为用于安装在连续生产线中的模块化单元，并且可以被自动控制以周期性地校准其测量。

公开(公告)号：US06814317B2

公开(公告)日：2004-11-09

申请号：US10182124

申请日：2002-12-11

申请人： Yasushi Watanabe ,  Yuji Iwase ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Yuji Iwase ,  Kiyoshi Morimoto

IPC分类号： B05B100

CPC分类号： B30B15/0011 ,  A61J3/10

摘要： A quantitative discharge apparatus for powder material, comprising: a tubular body for storing powder material; and an elastic membrane having plural penetrating apertures, the membrane constituting a bottom of the tubular body. The elastic membrane is vibrated by applying a positive pulsating vibration air, and thereby discharging powder material stored in the tubular body from the penetrating apertures of the elastic membrane. The plural penetrating apertures of the elastic membrane are formed on the circumference of a circle, of which center is a specific point of the elastic membrane.

摘要翻译： 一种用于粉末材料的定量排放装置，包括：用于储存粉末材料的管状体; 以及具有多个贯通孔的弹性膜，所述膜构成所述管状体的底部。 通过施加正的脉动振动空气来振动弹性膜，从而将存储在管状体中的粉末材料从弹性膜的穿透孔排出。 弹性膜的多个穿透孔形成在圆的圆周上，其中心是弹性膜的特定点。

公开(公告)号：US06764695B1

公开(公告)日：2004-07-20

申请号：US09806761

申请日：2001-04-03

申请人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase

发明人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase

IPC分类号： A61K920

CPC分类号： B30B15/0011 ,  A61K9/282

摘要： A tablet including active substance affected by lubricant, wherein the tablet is comprised of compressed mixture of active substance and adjuvant except for lubricant, and lubricant exists only on the surface of the tablet but is not included in the tablet. Such a tablet production method comprising the steps of producing mixture of active substance affected by lubricant and adjuvant, mixing lubricant powder with positive pulsating vibration air for dispersion, spraying the lubricant powder dispersed by the positive vibration air on a lower surface of an upper punch, an upper surface of a lower punch and an inner circumferential wall of a die, and tabletting the mixture by means of the upper and lower punches and the die.

摘要翻译： 包含受润滑剂影响的活性物质的片剂，其中片剂由活性物质和辅助剂的压缩混合物组成，除了润滑剂，润滑剂仅存在于片剂的表面上，但不包括在片剂中。 这样的片剂的制造方法，其特征在于，包括：将由润滑剂和助剂影响的活性物质的混合物混合，将润滑剂粉末与用于分散的正脉动振动空气混合，将由正振动空气分散的润滑剂粉末喷洒在上冲头的下表面上， 下冲头的上表面和模具的内周壁，并且通过上下冲头和模具对混合物进行压片。

公开(公告)号：US20050147666A1

公开(公告)日：2005-07-07

申请号：US10506349

申请日：2003-03-06

申请人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

发明人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/22 ,  A61P3/06

CPC分类号： A61K31/22 ,  A61K9/0056 ,  A61K9/2018

摘要： According to the present invention, provided are an intraorally rapidly disintegrable tablet which comprises D-mannitol and a disintegrator in addition to fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent; a process for producing an intraorally rapidly disintegrable tablet which comprises mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, and subjecting the material to compression molding; and an intraorally rapidly disintegrable tablet which is prepared by mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, subjecting the material to compression molding.

摘要翻译： 根据本发明，提供了除了通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒以外还含有D-甘露糖醇和崩解剂的口腔内快速崩解片剂， 一种生产口腔内快速崩解片剂的方法，其包括将D-甘露糖醇和崩解剂与通过将水溶性药理学活性成分和吸附剂的混合物制粒而制备的细粒混合，得到压缩成型材料， 压缩成型; 以及通过将D-甘露糖醇和崩解剂与通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒混合而制备的口腔内快速崩解片剂，得到压缩成型材料，将其压缩成型 。

公开(公告)号：US06607008B1

公开(公告)日：2003-08-19

申请号：US09869040

申请日：2001-08-22

申请人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

发明人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

IPC分类号： B06B118

CPC分类号： F16K11/0525 ,  B06B1/18 ,  F26B3/0926 ,  F26B21/12 ,  G10K7/06 ,  Y10T137/86405

摘要： Pulsating vibration air generation apparatus comprising a cylindrical casing having an air supply port connected with an air source and a wave transmission port provided at the circumferential surface thereof, and a drum type rotary valve constructed rotatably in the casing, wherein the air supply port is located where a circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the wave transmission port is located apart from where the circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the drum type rotary valve is comprised of a rotary support shaft at a center axis, one end of the rotary valve is opened, another end of the rotary valve is closed, at least one ventilation window is provided at the circumferential surface of the rotary valve, the rotary valve is contained in the casing in such a manner that the open end of the rotary valve faces to the wave transmission port of the casing, and the at least one ventilation window provided at the circumferential surface of the rotary valve is designed to intermittently meet the air supply port according to rotation of the valve when a rotary drive apparatus is connected with the rotary support shaft and the rotary drive apparatus is driven.

摘要翻译： 脉冲振动空气产生装置，包括：具有与空气源连接的空气供给口的圆筒形壳体和设置在其圆周表面的波浪传送口;以及滚筒式旋转阀，其可旋转地构造在所述壳体中，其中所述空气供给口位于 当旋转阀被容纳在壳体中时旋转阀的圆周表面定位，当旋转阀被容纳在壳体中时，波传播口位于旋转阀的圆周表面位于其周围的位置，滚筒 旋转阀由中心轴线的旋转支撑轴构成，旋转阀的一端开口，旋转阀的另一端关闭，在旋转阀的圆周面上设置至少一个通风窗， 旋转阀以这样的方式容纳在壳体中，使得旋转阀的开口端面向th的波浪传输端口 并且设置在旋转阀的圆周表面处的至少一个通风窗被设计成当旋转驱动装置与旋转支撑轴和旋转驱动器连接时，根据阀的旋转间歇地与空气供应口相遇 装置被驱动。

公开(公告)号：US06342248B1

公开(公告)日：2002-01-29

申请号：US09285062

申请日：1999-04-02

申请人： Junichi Miyabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Shigemitsu Miura ,  Eiji Hayakawa ,  Kunio Ito

发明人： Junichi Miyabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Shigemitsu Miura ,  Eiji Hayakawa ,  Kunio Ito

IPC分类号： A61K944

CPC分类号： A61J7/0007 ,  A61J1/035 ,  A61J3/10 ,  A61K9/2072 ,  B65D75/327 ,  B65D2575/3218

摘要： A dividable tablet is not chipped, can be divided easily and accurately, has excellent impact resistance and rarely causes twining in the film-coating step, wherein a dividing line is formed along a center line on the upper surface of the tablet, ridgelines are each located on an inner side of the peripheral portion of the tablet to surround the dividing line in two areas defined by the dividing line on the upper surface of the tablet, the lower surface of the tablet gradually rises from the peripheral portion of the tablet toward the center portion thereof, and areas around the ridgelines are each formed by a convex surface.

摘要翻译： 可分割片剂不会碎裂，可以容易且准确地分割，具有优异的耐冲击性，并且在薄膜包衣步骤中很少引起缠绕，其中沿着片剂上表面的中心线形成分割线，每个棱线 位于片剂的周边部分的内侧，以在片剂上表面上的分界线限定的两个区域中围绕分隔线，片剂的下表面从片剂的周边部分逐渐向 中心部分，并且脊线周围的区域各自由凸面形成。

公开(公告)号：US20050173555A1

公开(公告)日：2005-08-11

申请号：US10515996

申请日：2003-05-30

申请人： Eiichiro Hirota ,  Kimiaki Hayakawa ,  Yuji Iwase ,  Hirokazu Yoshimoto ,  Kiyoshi Morimoto

发明人： Eiichiro Hirota ,  Kimiaki Hayakawa ,  Yuji Iwase ,  Hirokazu Yoshimoto ,  Kiyoshi Morimoto

IPC分类号： B05B7/14 ,  B05B12/08 ,  G01N21/59 ,  B67D5/08 ,  B67D5/38

CPC分类号： B05B7/1404 ,  B05B7/1445 ,  B05B12/08 ,  G01N21/59

摘要： A powder concentration measuring apparatus comprising a pair of purge gas introducing paths being provided across a material measuring path which introduces a powder material pneumatically transported, a pair of transparent windows being provided so that said material measuring path is viewable through said pair of purge gas introducing paths at the one of the transparent windows, and the light receiving device being provided at the other of the transparent windows, and a powder concentration operation and control means, wherein the control means calculates a powder concentration depending on the light amount received by the light receiving device when a light beam is projected into the material measuring path from the light projecting device.

摘要翻译： 一种粉末浓度测量装置，包括一对吹扫气体导入路径，横跨材料测量路径设置，所述材料测量路径引入气动输送的粉末材料，设置一对透明窗口，使得所述材料测量路径可通过所述一对吹扫气体引入 在透明窗口中的一个处的路径和设置在另一个透明窗口处的光接收装置以及粉末浓度操作和控制装置，其中控制装置根据由光接收的光量计算粉末浓度 当光束从投光装置投射到材料测量路径中时，接收装置。

公开(公告)号：US06776361B1

公开(公告)日：2004-08-17

申请号：US10019936

申请日：2002-04-24

申请人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Kiyoshi Morimoto

IPC分类号： A02C1504

CPC分类号： B30B15/0011 ,  B05B7/1404 ,  B05B7/144

摘要： A powdered material spraying device comprising a quantitative spraying device provided for a material discharge port of the powdered material storage hopper via a material feed valve, a cover being provided for the material feed port of the powdered material storage hopper. The spraying device includes a cylindrical body connected with the material discharge port of the powdered material storage hopper, an elastic membrane with a penetrating aperture provided so as to form a bottom of the cylindrical body at its lower opening end, and a dispersion chamber connected under the lower opening end of the cylindrical body via the elastic membrane. The dispersion chamber has a pulsating vibration air supply port for supplying a positive pulsating vibration air to the dispersion chamber and a discharge port. A bypass pipe is connected between the cylindrical body and the dispersion chamber and the powdered material is sprayed from a tip end of a conduit connected with the discharge port of the dispersion chamber.

摘要翻译： 一种粉末喷涂装置，其特征在于，包括：定量喷射装置，其经由供料阀设置在所述粉料储存料斗的排料口上，为所述粉料储存料斗的料料供给口设置盖。 喷射装置包括与粉料储存料斗的材料排出口连接的圆柱体，具有穿孔的弹性膜，其设置成在其下开口端形成圆柱体的底部，并且分隔室连接在 圆柱体的下开口端经由弹性膜。 分散室具有用于向分散室和排出口供给正脉动振动空气的脉动振动空气供给口。 旁通管连接在圆柱体和分散室之间，并且粉末材料从与分散室的排出口连接的导管的末端喷射。

公开(公告)号：US06302573B1

公开(公告)日：2001-10-16

申请号：US09289556

申请日：1999-04-12

申请人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

发明人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

IPC分类号： B01F1302

CPC分类号： B01F13/0266 ,  B01F3/18 ,  B65G53/22

摘要： A mixing and blending method for powdered or granular material includes supplying pulsating vibration air into an airtight tank from a bottom thereof. An airtight tank having a porous bottom plate on which the material is stored is provided for the mixing and blending method. In the system pulsating vibration air is generated by periodically increasing and decreasing the amount of blowing air at a low frequency. Pulsating vibration air is introduced into the airtight tank from the bottom of the airtight tank so as to generate air flow going upward through the porous bottom of the airtight tank. As a result, powdered or granular material stored on the porous bottom plate in the airtight tank is uniformly mixed and blended in the airtight tank while continuously moving up and down as in a convectional manner.

摘要翻译： 用于粉末或颗粒材料的混合和混合方法包括将脉动振动空气从其底部供应到气密罐中。 提供了一种具有多孔底板的密封罐，其上储存有材料用于混合和混合方法。 在该系统中，通过周期性地增加和减少低频吹送空气的量来产生脉动振动空气。 脉动振动空气从密封罐的底部引入密封罐中，以产生向上通过密封罐的多孔底部的空气流。 结果，将保存在密封罐中的多孔底板上的粉状或颗粒状材料均匀地混合并混合在密封罐中，同时以对流方式连续上下移动。