公开(公告)号：US20050147666A1

公开(公告)日：2005-07-07

申请号：US10506349

申请日：2003-03-06

申请人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

发明人： Motohiro Ohta ,  Yuji Iwase ,  Naohiro Saito ,  Kiyoshi Morimoto

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/22 ,  A61P3/06

CPC分类号： A61K31/22 ,  A61K9/0056 ,  A61K9/2018

摘要： According to the present invention, provided are an intraorally rapidly disintegrable tablet which comprises D-mannitol and a disintegrator in addition to fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent; a process for producing an intraorally rapidly disintegrable tablet which comprises mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, and subjecting the material to compression molding; and an intraorally rapidly disintegrable tablet which is prepared by mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, subjecting the material to compression molding.

摘要翻译： 根据本发明，提供了除了通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒以外还含有D-甘露糖醇和崩解剂的口腔内快速崩解片剂， 一种生产口腔内快速崩解片剂的方法，其包括将D-甘露糖醇和崩解剂与通过将水溶性药理学活性成分和吸附剂的混合物制粒而制备的细粒混合，得到压缩成型材料， 压缩成型; 以及通过将D-甘露糖醇和崩解剂与通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒混合而制备的口腔内快速崩解片剂，得到压缩成型材料，将其压缩成型 。

公开(公告)号：US08357396B2

公开(公告)日：2013-01-22

申请号：US13282271

申请日：2011-10-26

申请人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

公开(公告)号：US20060159759A1

公开(公告)日：2006-07-20

申请号：US10546439

申请日：2004-03-05

申请人： Motohiro Ohta ,  Kiyoshi Morimoto ,  Muneko Kuboyama ,  Hirokazu Yoshimoto ,  Hideo Kawabe

发明人： Motohiro Ohta ,  Kiyoshi Morimoto ,  Muneko Kuboyama ,  Hirokazu Yoshimoto ,  Hideo Kawabe

IPC分类号： A61K9/24 ,  A61K31/198

CPC分类号： A61K31/401 ,  A23L33/175 ,  A23L33/30 ,  A61K9/0058 ,  A61K9/1617 ,  A61K31/198

摘要： The present invention provides a tablet which comprises a water-absorbent amino acid and a coating agent which is soluble in ethanol and hardly soluble in water. The tablet of the present invention is useful as amino acid preparations for sports, dieting, or pharmaceuticals, and also useful as nutritional supplements, pharmaceuticals and the like in order to supply nutritious of amino acids effective to human health maintenance, or enhance physiological activity of human tissues.

摘要翻译： 本发明提供一种片剂，其包含吸水性氨基酸和可溶于乙醇且几乎不溶于水的包衣剂。 本发明的片剂可用作运动，节食或药物的氨基酸制剂，并且还可用作营养补充剂，药物等，以提供对人体健康维持有效的氨基酸营养素，或增强生理活性 人体组织。

公开(公告)号：US06432534B1

公开(公告)日：2002-08-13

申请号：US09555660

申请日：2000-09-14

申请人： Eiji Hayakawa ,  Motohiro Ohta ,  Hiroyuki Morimoto ,  Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kunio Ito ,  Sanji Tokuno

发明人： Eiji Hayakawa ,  Motohiro Ohta ,  Hiroyuki Morimoto ,  Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kunio Ito ,  Sanji Tokuno

IPC分类号： B32B516

CPC分类号： A61J3/10 ,  B30B11/08 ,  B30B15/0011 ,  Y10T428/2991

摘要： A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied

摘要翻译： 一种通过设置有冲头和模具的压片机生产包含活性成分，稀释剂和润滑剂的片剂的方法，包括以下步骤： 制备包括活性组分，稀释剂和润滑剂的一部分的成型材料; 将大部分剩余量的润滑剂施加到冲头的表面和模具的表面上; 并通过施加润滑剂的表面的冲头和施加润滑剂的表面的模具对成型材料进行压片

公开(公告)号：US20120135076A1

公开(公告)日：2012-05-31

申请号：US13282271

申请日：2011-10-26

申请人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20 ,  B02C23/00

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

公开(公告)号：US08071128B2

公开(公告)日：2011-12-06

申请号：US10356641

申请日：2003-06-20

申请人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

公开(公告)号：US20060039967A1

公开(公告)日：2006-02-23

申请号：US10522946

申请日：2003-08-08

申请人： Motohiro Ohta ,  Kiyoshi Morimoto ,  Muneko Kuboyama ,  Hirokazu Yoshimoto ,  Hideo Kawabe ,  Takeshi Shibasaki

发明人： Motohiro Ohta ,  Kiyoshi Morimoto ,  Muneko Kuboyama ,  Hirokazu Yoshimoto ,  Hideo Kawabe ,  Takeshi Shibasaki

IPC分类号： A61K9/20 ,  A61K31/198

CPC分类号： A61K9/0056 ,  A23L33/175 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/198

摘要： The present invention provides a chewable tablet having an improved oral disintegration property, which is easily chewed and capable of containing a large amount of an amino acid depending on need, more specifically, a chewable tablet comprising an amino acid and an oral disintegration promoting agent.

摘要翻译： 本发明提供具有改善的口腔崩解性的咀嚼片，其易于咀嚼并且能够根据需要含有大量的氨基酸，更具体地说，包含氨基酸和口腔崩解促进剂的咀嚼片。

公开(公告)号：US06814317B2

公开(公告)日：2004-11-09

申请号：US10182124

申请日：2002-12-11

申请人： Yasushi Watanabe ,  Yuji Iwase ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Yuji Iwase ,  Kiyoshi Morimoto

IPC分类号： B05B100

CPC分类号： B30B15/0011 ,  A61J3/10

摘要： A quantitative discharge apparatus for powder material, comprising: a tubular body for storing powder material; and an elastic membrane having plural penetrating apertures, the membrane constituting a bottom of the tubular body. The elastic membrane is vibrated by applying a positive pulsating vibration air, and thereby discharging powder material stored in the tubular body from the penetrating apertures of the elastic membrane. The plural penetrating apertures of the elastic membrane are formed on the circumference of a circle, of which center is a specific point of the elastic membrane.

摘要翻译： 一种用于粉末材料的定量排放装置，包括：用于储存粉末材料的管状体; 以及具有多个贯通孔的弹性膜，所述膜构成所述管状体的底部。 通过施加正的脉动振动空气来振动弹性膜，从而将存储在管状体中的粉末材料从弹性膜的穿透孔排出。 弹性膜的多个穿透孔形成在圆的圆周上，其中心是弹性膜的特定点。

公开(公告)号：US07131828B2

公开(公告)日：2006-11-07

申请号：US10257068

申请日：2001-04-12

申请人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Satoru Hiruta

发明人： Yasushi Watanabe ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Satoru Hiruta

IPC分类号： B29C33/60 ,  B29C43/28

CPC分类号： B30B11/08 ,  B30B15/0011 ,  Y10T83/9423

摘要： A powder material application apparatus capable of applying powder material uniformly onto lower surfaces of plural upper punches, upper surfaces of plural lower punches and inner circumferences of plural dies of a tabletting machine. Powder material is applied on a material contacting surface of the lower punch by spraying powder material mixed with air from a powder material spray port for lower punch of a powder material application part for lower punch. Powder material is applied on a material contacting surface of the upper punch wherein powder material is not applied enough according to gravity by spraying powder material mixed with air from a powder material spray port for upper punch while the upper punch moves from an initial end to a terminal end of the powder material spray port for upper punch. The powder material spray port for upper punch is provided along the rotary orbit of the upper punches and is elongated more than the powder material spray port for lower punch.

摘要翻译： 一种粉末材料施加装置，其能够将粉末材料均匀地施加到多个上冲头的下表面，多个下冲头的上表面和压片机的多个模具的内周。 粉末材料通过喷射与空气混合的粉末材料施加在下冲头的材料接触表面上，粉末材料喷雾口用于下冲头的粉末材料施加部件的下冲头。 将粉末材料施加在上冲头的材料接触表面上，其中粉末材料根据重力不能充分施加，喷射与来自上冲头的粉末材料喷雾口的空气混合的粉末材料，同时上冲头从初始端移动到 粉末末端末端用于上冲头喷雾口。 上冲头的粉料喷射口沿着上冲头的旋转轨道设置，并且比用于下冲头的粉末喷射口更细。

公开(公告)号：US06607008B1

公开(公告)日：2003-08-19

申请号：US09869040

申请日：2001-08-22

申请人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

发明人： Hirokazu Yoshimoto ,  Kiyoshi Morimoto ,  Yuji Iwase ,  Kazue Murata

IPC分类号： B06B118

CPC分类号： F16K11/0525 ,  B06B1/18 ,  F26B3/0926 ,  F26B21/12 ,  G10K7/06 ,  Y10T137/86405

摘要： Pulsating vibration air generation apparatus comprising a cylindrical casing having an air supply port connected with an air source and a wave transmission port provided at the circumferential surface thereof, and a drum type rotary valve constructed rotatably in the casing, wherein the air supply port is located where a circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the wave transmission port is located apart from where the circumferential surface of the rotary valve is positioned when the rotary valve is contained in the casing, the drum type rotary valve is comprised of a rotary support shaft at a center axis, one end of the rotary valve is opened, another end of the rotary valve is closed, at least one ventilation window is provided at the circumferential surface of the rotary valve, the rotary valve is contained in the casing in such a manner that the open end of the rotary valve faces to the wave transmission port of the casing, and the at least one ventilation window provided at the circumferential surface of the rotary valve is designed to intermittently meet the air supply port according to rotation of the valve when a rotary drive apparatus is connected with the rotary support shaft and the rotary drive apparatus is driven.

摘要翻译： 脉冲振动空气产生装置，包括：具有与空气源连接的空气供给口的圆筒形壳体和设置在其圆周表面的波浪传送口;以及滚筒式旋转阀，其可旋转地构造在所述壳体中，其中所述空气供给口位于 当旋转阀被容纳在壳体中时旋转阀的圆周表面定位，当旋转阀被容纳在壳体中时，波传播口位于旋转阀的圆周表面位于其周围的位置，滚筒 旋转阀由中心轴线的旋转支撑轴构成，旋转阀的一端开口，旋转阀的另一端关闭，在旋转阀的圆周面上设置至少一个通风窗， 旋转阀以这样的方式容纳在壳体中，使得旋转阀的开口端面向th的波浪传输端口 并且设置在旋转阀的圆周表面处的至少一个通风窗被设计成当旋转驱动装置与旋转支撑轴和旋转驱动器连接时，根据阀的旋转间歇地与空气供应口相遇 装置被驱动。