公开(公告)号：US20190048053A1

公开(公告)日：2019-02-14

申请号：US16074086

申请日：2017-02-03

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Varda ROTTER ,  Moshe OREN ,  Perry TAL ,  Shay EIZENBERGER ,  Avi BEN-SHIMON

IPC: C07K14/47 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K9/00

Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.

公开(公告)号：US20220251159A1

公开(公告)日：2022-08-11

申请号：US17549369

申请日：2021-12-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD

Inventor： Varda ROTTER ,  Moshe OREN ,  Perry TAL ,  Shay EIZENBERGER ,  Avi BEN-SHIMON

IPC: C07K14/47 ,  A61P35/00 ,  C12N15/09

Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.