公开(公告)号：US20220392571A1

公开(公告)日：2022-12-08

申请号：US17884594

申请日：2022-08-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Amos TANAY ,  Amir GILADI ,  Merav COHEN

IPC: G16B25/10

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

公开(公告)号：US20230078148A1

公开(公告)日：2023-03-16

申请号：US17990770

申请日：2022-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Amos TANAY ,  Elad CHOMSKY ,  Yonatan STELZER ,  Raz BEN-YAIR

IPC: G01N33/58 ,  G01N1/30 ,  G06V20/69

Abstract: A method of identifying a molecular composition and a spatial position of a single cell comprised in a 3 dimensional structure comprising a plurality of cells is provided.

公开(公告)号：US20210293820A1

公开(公告)日：2021-09-23

申请号：US17334862

申请日：2021-05-31

Applicant: Yeda Research and Development Co. Ltd. ,  Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis

Inventor： Ido AMIT ,  Hanjie LI ,  Amos TANAY ,  Ido YOFE ,  Yaniv EYAL-LUBLING ,  Antonius Nicolaas Maria SCHUMACHER ,  Anne Magdalena VAN DER LEUN

IPC: G01N33/574 ,  C12N15/113 ,  G01N33/50

Abstract: Method of activating dysfunctional T cells, determining responsiveness of a subject having a tumor to an immune checkpoint inhibition are provided. Also provided is an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor. Additionally or alternatively provided is an immune checkpoint inhibitor and an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor.