公开(公告)号：US20210177895A1

公开(公告)日：2021-06-17

申请号：US17183593

申请日：2021-02-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Merav COHEN ,  Amir GILADI

IPC: A61K35/15 ,  C12N5/0787

Abstract: A method of treating a disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in a subject in need thereof is provided. The method comprising: (a) culturing basophils in the presence of IL33 and/or GM-SCF; and (b) administering to the subject a therapeutically effective amount of the basophils following the culturing, thereby treating the disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in the subject.

公开(公告)号：US20220392571A1

公开(公告)日：2022-12-08

申请号：US17884594

申请日：2022-08-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Amos TANAY ,  Amir GILADI ,  Merav COHEN

IPC: G16B25/10

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

公开(公告)号：US20170348393A1

公开(公告)日：2017-12-07

申请号：US15524634

申请日：2015-11-05

Applicant: Yeda Research And Development Co., Ltd.

Inventor： Michal SCHWARTZ-EISENBACH ,  Ido AMIT ,  Merav COHEN ,  Orit MATCOVICH

IPC: A61K38/21

CPC classification number: A61K38/215 ,  A61K9/0085 ,  A61P25/28

Abstract: A method of upregulating an anti-inflammatory response in a central nervous system (CNS) of a subject in need thereof is disclosed. The method comprising locally administering to the CNS of the subject a therapeutically effective amount of IFN-beta, thereby upregulating the anti-inflammatory response in the CNS of the subject. Methods of treating an inflammation in a CNS or treating a disease, disorder, condition or injury of a CNS of a subject are also disclosed.