公开(公告)号：US10829561B2

公开(公告)日：2020-11-10

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US09631028B2

公开(公告)日：2017-04-25

申请号：US14383571

申请日：2013-03-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani ,  Assaf Alon

IPC: C07K16/00 ,  C07K16/40 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

公开(公告)号：US20160122765A1

公开(公告)日：2016-05-05

申请号：US14849013

申请日：2015-09-09

Applicant: Arizona Board of Regents, a Body Corporate of the State of Arizona Acting for and on Behalf of Arizo ,  Yeda Research and Development Co. Ltd.

Inventor： Douglas LAKE ,  Benjamin Katchman ,  Deborah Fass

IPC: C12N15/113

CPC classification number: A61K39/3955 ,  A61K38/44 ,  A61K39/39558 ,  A61K2121/00 ,  C07K16/40 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/26 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y108/03002 ,  G01N33/5008 ,  G01N33/5011

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

Abstract translation: 本发明提供了通过施用静滴蛋白巯基氧化酶1（QSOX1）的抑制剂，包含这种抑制剂的组合物以及鉴定这种抑制剂的方法来进行肿瘤治疗的方法。

公开(公告)号：US20150110786A1

公开(公告)日：2015-04-23

申请号：US14383571

申请日：2013-03-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani ,  Assaf Alon

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

Abstract translation: 公开了抑制或预防基底膜中层粘连蛋白组合的方法。 该方法包括使组织与抑制QSOX1活性或表达的试剂接触，由此抑制或预防基底膜中的层粘连蛋白的组装。