公开(公告)号：US10829561B2

公开(公告)日：2020-11-10

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US20180273639A1

公开(公告)日：2018-09-27

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  C07K16/18 ,  A61K39/395

CPC classification number: C07K16/40 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K39/395 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US09631028B2

公开(公告)日：2017-04-25

申请号：US14383571

申请日：2013-03-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani ,  Assaf Alon

IPC: C07K16/00 ,  C07K16/40 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

公开(公告)号：US20150110786A1

公开(公告)日：2015-04-23

申请号：US14383571

申请日：2013-03-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani ,  Assaf Alon

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

Abstract translation: 公开了抑制或预防基底膜中层粘连蛋白组合的方法。 该方法包括使组织与抑制QSOX1活性或表达的试剂接触，由此抑制或预防基底膜中的层粘连蛋白的组装。