公开(公告)号：US20040253218A1

公开(公告)日：2004-12-16

申请号：US10810653

申请日：2004-03-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ester Yoles ,  Ehud Hauben ,  Irun R. Cohen ,  Pierre Beserman ,  Alon Monsonego ,  Gila Moalem

IPC: A61K045/00 ,  A61K038/17

CPC classification number: A61K38/1709 ,  A61K39/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/5158 ,  C07K14/47 ,  C07K14/705

Abstract: Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, either the central nervous system or the peripheral nervous system, are provided. Treatment involves administering NS-specific activated T cells, or an NS-specific antigen or analog thereof, a peptide derived therefrom or an analog or derivative of said peptide, or a nucleotide sequence encoding said antigen or peptide, or any combination thereof.

公开(公告)号：US20040248802A1

公开(公告)日：2004-12-09

申请号：US10807414

申请日：2004-03-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Ester Yoles ,  Ehud Hauben

IPC: A61K038/17

CPC classification number: A61K38/02 ,  A61K39/00 ,  A61K39/0007 ,  A61K2039/5158

Abstract: Methods and compositions are provided for preventing or inhibiting neuronal degeneration, or for promoting nerve regeneration, in the central nervous system (CNS) or peripheral nervous system (PNS), or for protecting nerves from glutamate toxicity, which comprises administering to an individual in need thereof an effective amount of the copolymer poly-Glu,Tyr.

Abstract translation: 提供了用于在中枢神经系统（CNS）或周围神经系统（PNS）中预防或抑制神经元变性或促进神经再生或用于保护神经免受谷氨酸毒性的方法和组合物，其包括向有需要的个体施用 的有效量的共聚物聚-Glu，Tyr。

公开(公告)号：US20020072493A1

公开(公告)日：2002-06-13

申请号：US09893348

申请日：2001-06-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ehud Hauben ,  Irun R. Cohen ,  Pierre Beserman ,  Alon Mosonego ,  Gila Moalem

IPC: A61K038/17

CPC classification number: A61K38/1709 ,  A61K39/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/5158 ,  C07K14/47 ,  C07K14/705

Abstract: Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, eiteher the central nervous system or the peripheral nervous system, are provided. Treatment involves administering NS-specific activated T cells, or an NS-specific antigen or analog thereof, a peptide derived therefrom or an analog or derivative of said peptide, or a nucleotide sequence encoding said antigen or peptide, or any combination thereof.

Abstract translation: 提供了促进神经再生或赋予神经保护作用并预防或抑制神经系统内神经元变性，中枢神经系统或周围神经系统的组合物和方法。 治疗涉及施用NS-特异性活化T细胞或NS-特异性抗原或其类似物，从其衍生的肽或所述肽的类似物或衍生物，或编码所述抗原或肽的核苷酸序列或其任何组合。