公开(公告)号：US12161679B2

公开(公告)日：2024-12-10

申请号：US17318009

申请日：2021-05-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Elinav ,  Eran Segal

IPC: A61K35/741 ,  A23L33/00 ,  A23L33/105 ,  A23L33/135 ,  A61K31/352 ,  A61K35/74 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/689

Abstract: A method of analyzing the likelihood of weight regain in a subject who has reached a target weight by practicing a weight loss program is disclosed. The method comprises determining an amount or presence of at least one microbe and/or product thereof in the gut microbiome of the subject, wherein the amount of the at least one microbe is altered during a prior weight gain period of the subject to reach a level representative of an obese subject and further wherein the amount of the at least one microbe is retained at the level following the weight loss program, wherein the amount or presence of the at least one microbe or product thereof is predictive of weight regain.

公开(公告)号：US11610681B2

公开(公告)日：2023-03-21

申请号：US17151232

申请日：2021-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H50/20 ,  G16H50/70 ,  G06N20/00 ,  G16H10/60 ,  G16H70/00 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20200056152A1

公开(公告)日：2020-02-20

申请号：US16361852

申请日：2019-03-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Zelig Eshhar ,  Eran Elinav

IPC: C12N5/0783 ,  A61K39/00

Abstract: A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.

公开(公告)号：US20220031776A1

公开(公告)日：2022-02-03

申请号：US16644641

申请日：2018-09-07

Applicant: Keio University ,  BiomX Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Inventor： Kenya Honda ,  Koji Atarashi ,  Seiko Narushima ,  Eran Elinav ,  Rotem Sorek ,  Efrat Khabra ,  Hava Ben David ,  Eyal Weinstock ,  Sarah Pollock ,  Yulia Matiuhin ,  Naomi Zak

IPC: A61K35/76 ,  C12N7/00

Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.

公开(公告)号：US10923230B2

公开(公告)日：2021-02-16

申请号：US16412538

申请日：2019-05-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H50/20 ,  G16H50/70 ,  G06N20/00 ,  G06F19/00 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US12046371B2

公开(公告)日：2024-07-23

申请号：US18123435

申请日：2023-03-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H10/00 ,  G06N20/00 ,  G16H10/60 ,  G16H20/60 ,  G16H50/20 ,  G16H50/70 ,  G16H70/00

CPC classification number: G16H50/20 ,  G06N20/00 ,  G16H10/60 ,  G16H20/60 ,  G16H50/70 ,  G16H70/00 ,  Y02A90/10

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US11326147B2

公开(公告)日：2022-05-10

申请号：US16361852

申请日：2019-03-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Zelig Eshhar ,  Eran Elinav

IPC: C12N5/0783 ,  A61K39/00

Abstract: A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.

公开(公告)号：US10361003B2

公开(公告)日：2019-07-23

申请号：US15022643

申请日：2015-04-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H50/20 ,  G16H50/70 ,  G06N20/00 ,  G06F19/00

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.