公开(公告)号：US20230330051A1

公开(公告)日：2023-10-19

申请号：US18027168

申请日：2021-09-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Leviel FLUHR ,  Uria MOR

IPC: A61K31/201 ,  A61K31/198 ,  A61K31/465 ,  A61K45/06 ,  A23G4/12

CPC classification number: A61K31/201 ,  A61K31/198 ,  A61K31/465 ,  A61K45/06 ,  A23G4/12

Abstract: A method of treating obesity in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically increases the amount of hexadecadienoate (16:2n6), N-acetylglycine, 1-palmitoyl-2-gamma-linolenoyl-GPC (16:0/18:3n6) and/or Hexanoylglycine; or an agent that decreases the amount of dimethylglycine (DMG) in the fecal metabolome of the subject. Agents suitable for same are also disclosed.