公开(公告)号：US20210292338A1

公开(公告)日：2021-09-23

申请号：US17337570

申请日：2021-06-03

Applicant: Yeda Research and Development Co. Ltd. ,  Universitat de Barcelona ,  Institució Catalana de Recerca I Estudis Avançats

Inventor： Rony SEGER ,  Karen FLORES ,  Xavier BARRIL ALONSO ,  Carlos GALDEANO CANTADOR

IPC: C07D498/04 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.

公开(公告)号：US20210154261A1

公开(公告)日：2021-05-27

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Rand ARAFEH ,  Karen FLORES ,  Rony SEGER ,  Ehud WAINSTEIN

IPC: A61K38/10 ,  A61K31/519 ,  A61K31/4184 ,  A61P35/00

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.