公开(公告)号：US20160166582A1

公开(公告)日：2016-06-16

申请号：US15050502

申请日：2016-02-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irina LAVELIN ,  Varda ROTTER ,  Moshe OREN ,  Ami NAVON ,  Zvi KAM ,  Benjamin GEIGER

IPC: A61K31/555 ,  G01N33/50 ,  C07K14/47 ,  A61K31/522 ,  A61K31/47

CPC classification number: A61K31/555 ,  A61K31/47 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K33/34 ,  C07K14/4746 ,  C07K2319/40 ,  C07K2319/60 ,  C12N9/6421 ,  C12Y304/25001 ,  G01N33/5035

Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.