公开(公告)号：US20120089104A1

公开(公告)日：2012-04-12

申请号：US13108967

申请日：2011-05-16

申请人： Yefu WANG ,  Wei LI ,  Xiaozhou ZHOU

发明人： Yefu WANG ,  Wei LI ,  Xiaozhou ZHOU

IPC分类号： A61M35/00 ,  B05D3/00 ,  B05D5/00 ,  B05D1/38

CPC分类号： A61K31/708 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/662 ,  A61K31/7068 ,  A61K31/7072 ,  A61K47/20 ,  A61K47/22

摘要： An antiviral transdermal patch including a backing layer, a viscous polymer layer, and a protection film layer. The viscous polymer layer includes an antiviral agent, a viscous polymer, and a transdermal enhancer. The transdermal enhancer is laurocapram or a mixture thereof. The antiviral agent is a nucleoside antiviral drug with a daily delivery rate of less than 100 mg/day. The patch effectively promotes the penetration of a nucleoside antiviral agent into the blood circulation and avoids enzymolysis in the gastrointestinal tract and the first pass effect of the liver and reduces side effect of drugs, thereby inhibiting the replication of target viruses and reducing viral DNA level in the serum. A method for producing the patch is also provided. The raw materials involved in the invention are easily purchased from the market at a low cost.

摘要翻译： 一种抗病毒透皮贴剂，其包括背衬层，粘性聚合物层和保护膜层。 粘性聚合物层包括抗病毒剂，粘性聚合物和透皮增强剂。 透皮增强剂是月桂酰胺或其混合物。 抗病毒剂是每日输送率小于100mg /天的核苷抗病毒药物。 该贴剂有效地促进了核苷抗病毒剂渗透到血液循环中，避免了胃肠道中的酶解和肝脏的首过效应，降低了药物的副作用，从而抑制靶病毒的复制和降低病毒DNA水平 血清。 还提供了一种生产贴片的方法。 本发明涉及的原材料从市场上容易地以低成本购买。