专利检索 ap:("Yen-Ta LU" OR "Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital") AND inv:"Tsai-Yin WEI" 第 1 页

1.

发明申请
METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE 审中-公开

公开(公告)号：US20180141991A1

公开(公告)日：2018-05-24

申请号：US15735949

申请日：2016-06-12

申请人： Yen-Ta LU , Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital

发明人： Yen-Ta LU , Chia-Ming CHANG , Tsai-Yin WEI

IPC分类号： C07K14/705 , A61K38/17 , A61P37/06 , A61K47/59 , A61K47/64 , A61K45/06

CPC分类号： C07K16/2845 , A61K38/00 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61K47/59 , A61K47/643 , A61P37/06 , C07K14/705 , C07K14/70503 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/70

摘要： A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1 polypeptide to the immune cell suppresses immunoresponse. A method for treating and/or preventing a disease associated with immune hyper-reactivity includes administering the TLT-1 polypeptide to a subject in need thereof.

2.

发明申请
BENZO-HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS 审中-公开

公开(公告)号：US20200339557A1

公开(公告)日：2020-10-29

申请号：US16925309

申请日：2020-07-09

申请人： MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL

发明人： Yen-Ta LU , Tzenge-Lien SHIH , Chia-Ming CHANG , Tsai-Yin WEI , Jen-Wei LIU

IPC分类号： C07D417/04 , A61K31/473 , C07D413/04 , C07D209/48 , A61K31/635 , C07D221/06 , A61K31/4035 , A61K39/395 , A61K45/06 , C07D221/14 , C07K16/28

摘要： The present invention relates to benzoxazole derivatives having the following Formula (I): The compounds of the present invention are found to possess the ability to decrease PD-L1 level, suggesting that the compounds of the invention can be used in cancer immunotherapy and treatment or prevention of sepsis or septic shock.

3.

发明申请
METHODS AND ANTIBODIES FOR MODULATION OF IMMUNORESPONSE 审中-公开

公开(公告)号：US20180362651A1

公开(公告)日：2018-12-20

申请号：US15735912

申请日：2016-06-12

申请人： Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital

发明人： Yen-Ta LU , Chia-Ming CHANG , Tsai-Yin WEI , I-Fang TSAI , Ling-Chiao WU

IPC分类号： C07K16/28 , A61K45/06 , A61K39/395

摘要： A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.