公开(公告)号：US09040132B2

公开(公告)日：2015-05-26

申请号：US13263008

申请日：2010-03-24

申请人： Yeon-Seok Choi ,  Hye-Kyung Kim ,  Eun-O Kim

发明人： Yeon-Seok Choi ,  Hye-Kyung Kim ,  Eun-O Kim

IPC分类号： B32B1/02 ,  B32B27/32 ,  B32B27/30 ,  B32B25/08 ,  B32B27/08

CPC分类号： B32B27/32 ,  B32B25/08 ,  B32B27/08 ,  B32B27/302 ,  B32B2307/40 ,  B32B2307/412 ,  B32B2439/00 ,  B32B2439/80 ,  B32B2535/00 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/2495 ,  Y10T428/31909 ,  Y10T428/31913

摘要： Disclosed are a medical multilayer film and use thereof. More specifically, disclosed are a medical multilayer film including: an outer layer comprising a propylene polymer selected from the group consisting of a polypropylene, a propylene copolymer and a combination thereof, an intermediate layer comprising 10 to 60% by weight of a propylene polymer selected from the group consisting of a polypropylene, a propylene copolymer and a combination thereof and 40 to 90% by weight of a thermoplastic elastomer, and an inner layer comprising 60 to 80% by weight of a propylene polymer selected from the group consisting of a polypropylene, a propylene copolymer and a combination thereof, 10 to 30% by weight of polyethylene, and 1 to 10% by weight of a thermoplastic elastomer, and use thereof. The multilayer film exhibits superior transparency, heat resistance and sealability as well as cold resistance, heat resistance, drop impact resistance and low-temperature impact resistance, thus being applicable to infusion solution containers, medical pouches, contrast medium containers and blood containers for packaging and administering medical solutions such as infusion solutions and blood.

摘要翻译： 公开了医用多层膜及其用途。 更具体地，公开了一种医疗多层膜，其包括：包含选自聚丙烯，丙烯共聚物及其组合的丙烯聚合物的外层，包含10至60重量％的选自丙烯聚合物的中间层 由聚丙烯，丙烯共聚物及其组合组成的组和40至90重量％的热塑性弹性体，以及包含60至80重量％的丙烯聚合物的内层，所述丙烯聚合物选自聚丙烯 ，丙烯共聚物及其组合，10〜30重量％的聚乙烯和1〜10重量％的热塑性弹性体及其用途。 多层膜具有优异的透明性，耐热性和密封性以及耐寒性，耐热性，耐滴落冲击性和耐低温冲击性，因此适用于输液溶液容器，医用袋，造影剂容器和包装用血容器 管理诸如输液和血液的医疗解决方案。

公开(公告)号：US08703813B2

公开(公告)日：2014-04-22

申请号：US13126979

申请日：2009-10-30

申请人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

发明人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

IPC分类号： C07D307/94 ,  A61K31/35

CPC分类号： C07D493/10

摘要： Provided is a compound having a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The compound having the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.

摘要翻译： 本发明提供具有螺状手性碳骨架的化合物，其立体异构体，其对映异构体，其体内可水解的前体或其药学上可接受的盐。 具有螺状手性碳骨架的化合物在肝脏中具有优异的成骨细胞分化活性，肥大细胞抑制活性和脂肪酸合成抑制活性。 因此，该化合物可以预期在骨质疏松症，脂肪肝和肥胖症的治疗中发挥创新作用。

公开(公告)号：US20110218240A1

公开(公告)日：2011-09-08

申请号：US13126979

申请日：2009-10-30

申请人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

发明人： Heon-Joong Kang ,  Jung-Rae Rho ,  Jeong-Ho Hong ,  Seung-Bum Park ,  Chan-Soo Shin ,  Jae-Hwan Lee ,  Jun-Young Hong ,  Eun-O Kim ,  Jeong-Ah Kim ,  Sang-Mi Oh

IPC分类号： A61K31/352 ,  C07D493/10 ,  A61P19/10 ,  A61P3/04 ,  A61P1/16

CPC分类号： C07D493/10

摘要： Provided are a novel compound with a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The novel compound with the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the novel compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.

摘要翻译： 本发明提供一种具有螺状手性碳骨架的新化合物，其立体异构体，其对映异构体，其体内可水解的前体或其药学上可接受的盐。 具有螺旋手性碳骨架的新型化合物在肝脏中具有优异的成骨细胞分化活性，肥大细胞抑制活性和脂肪酸合成抑制活性。 因此，新化合物可以预期在骨质疏松症，脂肪肝和肥胖症的治疗中发挥创新作用。