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公开(公告)号：US5942414A
公开(公告)日：1999-08-24
申请号：US465971
申请日：1995-06-06
申请人： Yi Li , Mark D. Adams
发明人： Yi Li , Mark D. Adams
IPC分类号： C07H21/04 , C07K14/705 , C12N15/09 , C12N15/12
CPC分类号： C07K14/705
摘要： Human G-protein Coupled receptor HIBEF51 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the human G-protein Coupled receptor HIBEF51 nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
摘要翻译： 公开了人G-蛋白偶联受体HIBEF51多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测人G-蛋白偶联受体HIBEF51核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。
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公开(公告)号：US5710019A
公开(公告)日：1998-01-20
申请号：US464340
申请日：1995-06-05
申请人： Yi Li , Mark D. Adams , Owen R. White
发明人： Yi Li , Mark D. Adams , Owen R. White
IPC分类号： A61K38/00 , C07K14/705 , C12P21/02 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： Disclosed are human K.sub.+ channel polypeptides and DNA (RNA) encoding such K.sub.+ channel polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques. Agonists for such K.sub.+ channel polypeptides are also disclosed. Such agonists may be used to treat epilepsy, stroke, hypertension, asthma, Parkinson's disease, schizophrenia, anxiety, depression and neurodegeneration. Also disclosed are antagonists against such polypeptides which may be used to treat AIDS, SLE, diabetes, multiple sclerosis and cancer. Also disclosed are diagnostic assays for detecting mutations in the polynucleotide sequences of the present invention.
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公开(公告)号：US5994506A
公开(公告)日：1999-11-30
申请号：US30582
申请日：1998-02-25
申请人： Daniel R. Soppet , Yi Li , Mark D. Adams
发明人： Daniel R. Soppet , Yi Li , Mark D. Adams
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , C12N15/12
CPC分类号： C07K14/70571 , C07K14/723 , A61K38/00 , C12N2799/026
摘要： A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
摘要翻译： 公开了人类肾上腺素能受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了肾上腺素能受体多肽的激动剂，其可以用于治疗性地刺激肾上腺素能受体和拮抗剂对抗这些肾上腺素能受体多肽的抑制剂及其用于拮抗肾上腺素能受体的用途。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。
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公开(公告)号：US5817477A
公开(公告)日：1998-10-06
申请号：US467568
申请日：1995-06-06
申请人： Daniel R. Soppet , Yi Li , Mark D. Adams
发明人： Daniel R. Soppet , Yi Li , Mark D. Adams
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , C12N15/12 , C12D21/02
CPC分类号： C07K14/70571 , C07K14/723 , A61K38/00 , C12N2799/026
摘要： A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
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公开(公告)号：US06936688B2
公开(公告)日：2005-08-30
申请号：US10125451
申请日：2002-04-19
申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/00
摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译： 公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。
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公开(公告)号：US06790826B2
公开(公告)日：2004-09-14
申请号：US10004832
申请日：2001-12-07
申请人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
发明人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
IPC分类号： A61K3816
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，并且使用这些多肽来治疗白血病，自身免疫疾病和与血液相关的疾病。 还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。 还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。
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公开(公告)号：US06518046B1
公开(公告)日：2003-02-11
申请号：US08793381
申请日：1997-05-19
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C12N1500
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： The present invention relates to Human Ck&bgr;-9 polypeptides and DNA (RNA) encoding such chemolcine polypeptides. Moreover, a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck&bgr;-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective disease, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck&bgr;-9 coding sequence and over-expression of the Ck&bgr;-9 protein.
摘要翻译： 本发明涉及人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）。 此外，公开了通过重组技术生产这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。
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公开(公告)号：US06383737B1
公开(公告)日：2002-05-07
申请号：US09732020
申请日：2000-12-08
IPC分类号： C12Q1527
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
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公开(公告)号：US06346246B1
公开(公告)日：2002-02-12
申请号：US09333033
申请日：1999-06-15
IPC分类号： A61K39395
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。
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公开(公告)号：US06255077B1
公开(公告)日：2001-07-03
申请号：US09325430
申请日：1999-06-04
IPC分类号： C12N1563
CPC分类号： C12N9/90 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y599/01002
摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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