公开(公告)号：US20100331413A1

公开(公告)日：2010-12-30

申请号：US12811477

申请日：2009-01-08

申请人： Ying Liu ,  Quanhai Liu ,  Yan Qin ,  Tong Wu ,  Zhiru Xu ,  Min-yu Liu ,  Fei Li ,  Yan Li ,  Michael J. Newman

发明人： Ying Liu ,  Quanhai Liu ,  Yan Qin ,  Tong Wu ,  Zhiru Xu ,  Min-yu Liu ,  Fei Li ,  Yan Li ,  Michael J. Newman

IPC分类号： A61K31/19 ,  C07C62/32 ,  C07C233/00 ,  C07C69/74 ,  C07H13/02 ,  A61P11/00 ,  A61P3/10 ,  A61P1/00 ,  A61P17/06 ,  A61P19/02

CPC分类号： C07J63/008

摘要： A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.

摘要翻译： 可以制备高纯度积雪草苷和药物级积雪草酸以及积雪草酸盐，用于配制适合于治疗关节炎，牛皮癣和其它炎性疾病以及肺纤维化，糖尿病性肾病和 其他纤维化疾病。

公开(公告)号：US08742167B2

公开(公告)日：2014-06-03

申请号：US12811477

申请日：2009-01-08

申请人： Ying Liu ,  Quanhai Liu ,  Yan Qin ,  Tong Wu ,  Zhiru Xu ,  Min-yu Liu ,  Fei Li ,  Yan Li ,  Michael J. Newman

发明人： Ying Liu ,  Quanhai Liu ,  Yan Qin ,  Tong Wu ,  Zhiru Xu ,  Min-yu Liu ,  Fei Li ,  Yan Li ,  Michael J. Newman

IPC分类号： C07C61/29

CPC分类号： C07J63/008

摘要： A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.

摘要翻译： 可以制备高纯度积雪草苷和药物级积雪草酸以及积雪草酸盐，用于配制适合于治疗关节炎，牛皮癣和其它炎性疾病以及肺纤维化，糖尿病性肾病和 其他纤维化疾病。

公开(公告)号：US08962880B2

公开(公告)日：2015-02-24

申请号：US14006198

申请日：2012-03-21

申请人： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

发明人： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

IPC分类号： C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/00

CPC分类号： C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/008

摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

摘要翻译： 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

公开(公告)号：US20140243553A1

公开(公告)日：2014-08-28

申请号：US14006198

申请日：2012-03-21

申请人： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

发明人： Guobin Ren ,  Ying Liu ,  Jinyao Chen ,  Xiaoling Huang ,  Lin Xiao ,  Li Cai ,  Zhen Zhang ,  Xuejun Wu ,  Haiyan Sun ,  Quanhai Liu ,  Liling Jin ,  Minyu Liu ,  Yifang Deng ,  Zhiru Xu ,  Renhai Chen ,  Chungang Li ,  Xiangduan Tan ,  Yan Qin

IPC分类号： C07C227/14 ,  C07C229/38

CPC分类号： C07C227/14 ,  C07C215/10 ,  C07C229/38 ,  C07J63/008

摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

摘要翻译： 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

公开(公告)号：USD1017569S1

公开(公告)日：2024-03-12

申请号：US29814624

申请日：2021-11-08

申请人： Zhiru Xu

设计人： Zhiru Xu

摘要： FIG. 1 is a top, front and right side perspective view of a record player with the lid open, showing my new design;
FIG. 2 is a top, rear and left side perspective view with the lid open;
FIG. 3 is a front elevational view thereof with the lid open;
FIG. 4 is a rear elevational view thereof with the lid open;
FIG. 5 is a left side elevational view thereof with the lid open;
FIG. 6 is a right side elevational view thereof with the lid open;
FIG. 7 is a top plan view thereof with the lid open;
FIG. 8 is a bottom plan view thereof with the lid open;
FIG. 9 is a top, front and right side perspective view with the lid closed;
FIG. 10 is a top, rear and left side perspective view with the lid closed;
FIG. 11 is a front elevational view thereof with the lid closed;
FIG. 12 is a rear elevational view thereof with the lid closed;
FIG. 13 is a left side elevational view thereof with the lid closed;
FIG. 14 is a right side elevational view thereof with the lid closed;
FIG. 15 is a top plan view thereof with the lid closed; and,
FIG. 16 is a bottom plan view thereof with the lid closed.
The surface located inside of the broken line rectangle on the bottom of the article forms no part of the claimed design.
The broken lines in the figures depict portions of the record player that form no part of the claimed design.