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    Specific human antibodies for selective cancer therapy
    1.
    发明申请
    Specific human antibodies for selective cancer therapy 审中-公开
    用于选择性癌症治疗的特异性人抗体

    公开(公告)号：US20070149768A1

    公开(公告)日：2007-06-28

    申请号：US11388025

    申请日：2006-03-22

    申请人： Yocheved Hagay ,  Janette Lazarovits ,  Rachel Guy ,  Orly Lifshitz ,  Esther Szanton ,  Avigdor Levanon ,  Daniel Plaksin ,  Tuvia Peretz

    发明人： Yocheved Hagay ,  Janette Lazarovits ,  Rachel Guy ,  Orly Lifshitz ,  Esther Szanton ,  Avigdor Levanon ,  Daniel Plaksin ,  Tuvia Peretz

    IPC分类号： C07K16/30

    CPC分类号： C07K16/005 ,  C07K16/3061 ,  C07K2317/565 ,  C07K2317/622

    摘要： The present invention is directed to a peptide or polypeptide comprising an Fv molecule, a construct thereof, a fragment of either, or a construct of a fragment having enhanced binding characteristics so as to bind selectively and/or specifically to a target cell in favor of other cells, wherein the binding selectivity or specificity is primarily determined by a first hypervariable region, and wherein the Fv is a scFv or a dsFv, and optionally having one or more tags. The enhanced binding is directed to a substantially exposed and/or over-expressed binding site on or in a target comprising a cell in favor of other cells on or in which the binding site is not substantially available and/or expressed. The invention is further directed to a method for isolating such peptides and polypeptides from a phage display library and to the nucleic acid molecules encoding them. The invention provides for a pharmaceutical composition comprising the peptide or polypeptide and kits for diagnosis and treatment of disease, specifically cancer, most specifically acute myeloid leukemia.

    摘要翻译： 本发明涉及一种肽或多肽，其包含Fv分子，其构建体，或具有增强的结合特性的片段的构建体或具有结合选择性和/或特异性靶向靶细胞的片段的构建体，有利于 其它细胞，其中结合选择性或特异性主要由第一高变区确定，并且其中Fv是scFv或dsFv，并且可选地具有一个或多个标签。 增强的结合涉及在靶上或靶上的基本上暴露和/或过表达的结合位点，其包含有利于结合位点基本上不可用和/或表达的其它细胞的细胞。 本发明还涉及从噬菌体展示文库和编码它们的核酸分子分离这些肽和多肽的方法。 本发明提供包含肽或多肽的药物组合物和用于诊断和治疗疾病，特别是癌症，尤其是急性骨髓性白血病的试剂盒。