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    Specific human antibodies for selective cancer therapy
    4.
    发明申请
    Specific human antibodies for selective cancer therapy 审中-公开
    用于选择性癌症治疗的特异性人抗体

    公开(公告)号：US20070149768A1

    公开(公告)日：2007-06-28

    申请号：US11388025

    申请日：2006-03-22

    申请人： Yocheved Hagay ,  Janette Lazarovits ,  Rachel Guy ,  Orly Lifshitz ,  Esther Szanton ,  Avigdor Levanon ,  Daniel Plaksin ,  Tuvia Peretz

    发明人： Yocheved Hagay ,  Janette Lazarovits ,  Rachel Guy ,  Orly Lifshitz ,  Esther Szanton ,  Avigdor Levanon ,  Daniel Plaksin ,  Tuvia Peretz

    IPC分类号： C07K16/30

    CPC分类号： C07K16/005 ,  C07K16/3061 ,  C07K2317/565 ,  C07K2317/622

    摘要： The present invention is directed to a peptide or polypeptide comprising an Fv molecule, a construct thereof, a fragment of either, or a construct of a fragment having enhanced binding characteristics so as to bind selectively and/or specifically to a target cell in favor of other cells, wherein the binding selectivity or specificity is primarily determined by a first hypervariable region, and wherein the Fv is a scFv or a dsFv, and optionally having one or more tags. The enhanced binding is directed to a substantially exposed and/or over-expressed binding site on or in a target comprising a cell in favor of other cells on or in which the binding site is not substantially available and/or expressed. The invention is further directed to a method for isolating such peptides and polypeptides from a phage display library and to the nucleic acid molecules encoding them. The invention provides for a pharmaceutical composition comprising the peptide or polypeptide and kits for diagnosis and treatment of disease, specifically cancer, most specifically acute myeloid leukemia.

    摘要翻译： 本发明涉及一种肽或多肽，其包含Fv分子，其构建体，或具有增强的结合特性的片段的构建体或具有结合选择性和/或特异性靶向靶细胞的片段的构建体，有利于 其它细胞，其中结合选择性或特异性主要由第一高变区确定，并且其中Fv是scFv或dsFv，并且可选地具有一个或多个标签。 增强的结合涉及在靶上或靶上的基本上暴露和/或过表达的结合位点，其包含有利于结合位点基本上不可用和/或表达的其它细胞的细胞。 本发明还涉及从噬菌体展示文库和编码它们的核酸分子分离这些肽和多肽的方法。 本发明提供包含肽或多肽的药物组合物和用于诊断和治疗疾病，特别是癌症，尤其是急性骨髓性白血病的试剂盒。

    Fibrin binding domain polypeptides and uses and methods of producing same
    7.
    发明授权
    Fibrin binding domain polypeptides and uses and methods of producing same 失效

    公开(公告)号：US07087722B1

    公开(公告)日：2006-08-08

    申请号：US09492971

    申请日：2000-01-27

    申请人： Tikva Vogel ,  Avigdor Levanon ,  Moshe Werber ,  Rachel Guy ,  Amos Panet

    发明人： Tikva Vogel ,  Avigdor Levanon ,  Moshe Werber ,  Rachel Guy ,  Amos Panet

    IPC分类号： A61K35/14 ,  A61K51/00 ,  A61K49/00 ,  C07K1/00 ,  C12Q1/56

    CPC分类号： A61K51/088 ,  C07K5/1021 ,  C07K7/06 ,  G01N33/60 ,  G01N2800/226

    摘要： This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of binding to fibrin. The invention further provides a method wherein the imaging agent is used for imaging a fibrin-containing substance, i.e., a thrombus or atherosclerotic plaque. Further provided are plasmids for expression of polypeptides having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of binding to fibrin, hosts containing these plasmids, methods of producing the polypeptides, methods of treatment using the polypeptides, and methods of recovering, refolding and reoxidizing the polypeptides. The invention also provides for purified polypeptides substantially free of other substances of human origin which have an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and which are capable of binding to fibrin.

    Fibrin binding domain polypeptides and uses and methods of producing same
    9.
    发明授权
    Fibrin binding domain polypeptides and uses and methods of producing same 失效
    纤维蛋白结合结构域多肽及其生产方法及用途

    公开(公告)号：US5679320A

    公开(公告)日：1997-10-21

    申请号：US259569

    申请日：1994-06-14

    申请人： Tikva Vogel ,  Avigdor Levanon ,  Moshe M. Werber ,  Rachel Guy ,  Amos Panet ,  Jacob Hartman ,  Hadassa Shaked

    发明人： Tikva Vogel ,  Avigdor Levanon ,  Moshe M. Werber ,  Rachel Guy ,  Amos Panet ,  Jacob Hartman ,  Hadassa Shaked

    IPC分类号： A61K49/00 ,  A61K51/08

    CPC分类号： A61K49/0004 ,  A61K49/0002 ,  A61K49/0008 ,  A61K51/082 ,  A61K51/088 ,  A61K2123/00

    摘要： This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of binding to fibrin. The invention further provides a method wherein the imaging agent is used for imagifig a fibrin-containing substance, i.e., a thrombus or atherosclerotic plaque. Further provided are plasmids for expression of polypeptides having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of binding to fibrin, hosts containing these plasmids, methods of producing the polypeptides, methods of treatment using the polypeptides, and methods of recovering, refolding and reoxidizing the polypeptides. The invention also provides for purified polypeptides substantially free of other substances of human origin which have an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and which are capable of binding to fibrin.

    摘要翻译： 本发明提供一种成像剂，其包含用可成像标记物标记的多肽，所述多肽具有基本上存在于天然存在的人纤连蛋白的纤维蛋白结合结构域中并且能够结合纤维蛋白的氨基酸序列。 本发明还提供了一种方法，其中显像剂用于含血纤维蛋白的物质，即血栓或动脉粥样硬化斑块。 还提供了用于表达多肽的质粒，其具有基本上存在于天然存在的人纤连蛋白的纤维蛋白结合结构域中的氨基酸序列，并且能够结合纤维蛋白，含有这些质粒的宿主，产生多肽的方法，使用 多肽和回收，重折叠和再氧化多肽的方法。 本发明还提供基本上不含人源的其它物质的纯化多肽，其具有基本上存在于天然存在的人纤连蛋白的纤维蛋白结合结构域中并且能够结合纤维蛋白的氨基酸序列。