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公开(公告)号:US07553933B2
公开(公告)日:2009-06-30
申请号:US11340715
申请日:2006-01-27
申请人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
IPC分类号: C07K14/00
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
摘要翻译: 属于与已知为细胞增殖调节基因的p53基因有关的家族基因类别的新型人类基因及其基因产物。 特征在于包含编码SEQ ID NO:1所示的氨基酸序列的碱基序列的人p51基因; 具有由SEQ ID NO:2所示的序列中的145〜1488个碱基组成的碱基序列的人p51基因; 含有这些基因的载体; 用这些载体转化的宿主细胞; 制备具有SEQ ID NO:1所示氨基酸序列的p51蛋白质的方法; 其包括培养上述宿主细胞并从由此获得的培养物中收获蛋白质; 和具有SEQ ID NO:1所示的氨基酸序列的p51蛋白。
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公开(公告)号:US07132276B1
公开(公告)日:2006-11-07
申请号:US09670568
申请日:1999-03-24
申请人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
IPC分类号: C12N15/63
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling whithin the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
摘要翻译: 与被称为细胞增殖调节基因的p53基因有关的家族基因类别及其基因产物的新型人类基因。 特征在于包含编码SEQ ID NO:1所示的氨基酸序列的碱基序列的人p51基因; 具有由SEQ ID NO:2所示的序列中的145〜1488个碱基组成的碱基序列的人p51基因; 含有这些基因的载体; 用这些载体转化的宿主细胞; 制备具有SEQ ID NO:1所示氨基酸序列的p51蛋白质的方法; 其包括培养上述宿主细胞并从由此获得的培养物中收获蛋白质; 和具有SEQ ID NO:1所示的氨基酸序列的p51蛋白。
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公开(公告)号:US07964367B2
公开(公告)日:2011-06-21
申请号:US12786018
申请日:2010-05-24
申请人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
IPC分类号: G01N33/574
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
摘要翻译: 属于与已知为细胞增殖调节基因的p53基因有关的家族基因类别的新型人类基因及其基因产物。 特征在于包含编码SEQ ID NO:1所示的氨基酸序列的碱基序列的人p51基因; 具有由SEQ ID NO:2所示的序列中的145〜1488个碱基组成的碱基序列的人p51基因; 含有这些基因的载体; 用这些载体转化的宿主细胞; 制备具有SEQ ID NO:1所示氨基酸序列的p51蛋白质的方法; 其包括培养上述宿主细胞并从由此获得的培养物中收获蛋白质; 和具有SEQ ID NO:1所示的氨基酸序列的p51蛋白。
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公开(公告)号:US07754857B2
公开(公告)日:2010-07-13
申请号:US12169213
申请日:2008-07-08
申请人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
IPC分类号: C07K16/00 , G01N33/536
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
摘要翻译: 属于与已知为细胞增殖调节基因的p53基因有关的家族基因类别的新型人类基因及其基因产物。 特征在于包含编码SEQ ID NO:1所示的氨基酸序列的碱基序列的人p51基因; 具有由SEQ ID NO:2所示的序列中的145〜1488个碱基组成的碱基序列的人p51基因; 含有这些基因的载体; 用这些载体转化的宿主细胞; 制备具有SEQ ID NO:1所示氨基酸序列的p51蛋白质的方法; 其包括培养上述宿主细胞并从由此获得的培养物中收获蛋白质; 和具有SEQ ID NO:1所示的氨基酸序列的p51蛋白。
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公开(公告)号:US20090142783A1
公开(公告)日:2009-06-04
申请号:US12169213
申请日:2008-07-08
申请人: Yoji IKAWA , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji IKAWA , Shuntaro Ikawa , Masuo Obinata
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
摘要翻译: 属于与已知为细胞增殖调节基因的p53基因有关的家族基因类别的新型人类基因及其基因产物。 特征在于包含编码SEQ ID NO:1所示的氨基酸序列的碱基序列的人p51基因; 具有由SEQ ID NO:2所示的序列中的145〜1488个碱基组成的碱基序列的人p51基因; 含有这些基因的载体; 用这些载体转化的宿主细胞; 制备具有SEQ ID NO:1所示氨基酸序列的p51蛋白质的方法; 其包括培养上述宿主细胞并从由此获得的培养物中收获蛋白质; 和具有SEQ ID NO:1所示的氨基酸序列的p51蛋白。
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公开(公告)号:US20060115852A1
公开(公告)日:2006-06-01
申请号:US11340715
申请日:2006-01-27
申请人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
发明人: Yoji Ikawa , Shuntaro Ikawa , Masuo Obinata
CPC分类号: C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/4746
摘要: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1.
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