公开(公告)号：US20110046400A1

公开(公告)日：2011-02-24

申请号：US12990111

申请日：2008-05-26

申请人： Yong Qin ,  Xianglin Deng ,  Xuan Zhou ,  Guofeng Yu ,  Ke Wang ,  Hao Song ,  Xiaolin Wang ,  Shan Huang

发明人： Yong Qin ,  Xianglin Deng ,  Xuan Zhou ,  Guofeng Yu ,  Ke Wang ,  Hao Song ,  Xiaolin Wang ,  Shan Huang

IPC分类号： C07D305/12

CPC分类号： C07D305/12 ,  C07D213/70

摘要： The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.

摘要翻译： 本发明涉及制备（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基）氧杂环丁烷-2-酮的方法和该方法的产物。 该方法包括以下步骤：a）还原由式（II）表示的物质以获得由式（III）表示的物质，然后氧化由式（III）表示的物质以形成由式（IV）表示的物质， ; b）用正辛酸酰化得到正辛酰氯，然后在碱性条件下将所得的正辛酰氯与2-巯基 - 吡啶缩合形成式（Ⅴ）表示的物质，然后转化成物质 由式（Ⅴ）代表由式（Ⅵ）表示的物质; c）在路易斯酸的催化条件下，使步骤a）中获得的物质与步骤b）中获得的物质反应，生成由式（Ⅶ）表示的物质，然后与路易斯酸反应。 这些公式中的符号的含义与描述中的符号的含义相同。

公开(公告)号：US08431726B2

公开(公告)日：2013-04-30

申请号：US12990111

申请日：2008-05-26

申请人： Yong Qin ,  Xianglin Deng ,  Xuan Zhou ,  Guofeng Yu ,  Ke Wang ,  Hao Song ,  Xiaolin Wang ,  Shan Huang

发明人： Yong Qin ,  Xianglin Deng ,  Xuan Zhou ,  Guofeng Yu ,  Ke Wang ,  Hao Song ,  Xiaolin Wang ,  Shan Huang

IPC分类号： C07D305/12

CPC分类号： C07D305/12 ,  C07D213/70

摘要： The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.

摘要翻译： 本发明涉及制备（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基）氧杂环丁烷-2-酮的方法和该方法的产物。 该方法包括以下步骤：a）还原由式（II）表示的物质以获得由式（III）表示的物质，然后氧化由式（III）表示的物质以形成由式（IV）表示的物质， ; b）用正辛酸酰化得到正辛酰氯，然后在碱性条件下将所得正辛酰氯与2-巯基 - 吡啶缩合形成式（Ⅴ）表示的物质，然后转化成物质 由式（Ⅴ）代表由式（Ⅵ）表示的物质; c）在路易斯酸的催化条件下，使步骤a）中获得的物质与步骤b）中获得的物质反应，生成由式（Ⅶ）表示的物质，然后与路易斯酸反应。 这些公式中的符号的含义与描述中的符号的含义相同。