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公开(公告)号：US08063077B2
公开(公告)日：2011-11-22
申请号：US12777956
申请日：2010-05-11
申请人： Yonghong Song , Zhaozhong J. Jia , Robert M. Scarborough , Carroll Scarborough, legal representative , Anjali Pandey
IPC分类号： A61K31/4412 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法和抑制血液样品凝固的方法。
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公开(公告)号：US20110160196A1
公开(公告)日：2011-06-30
申请号：US12976602
申请日：2010-12-22
IPC分类号： A61K31/4439 , C07D409/14 , C12N9/99 , C07D413/14 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D417/14 , A61K31/541 , A61P7/02 , A61P9/10
CPC分类号： C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat certain conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这些化合物的中间体，含有这些化合物的药物组合物，预防或治疗特征在于不想要的血栓形成的某些病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20120088795A1
公开(公告)日：2012-04-12
申请号：US13270170
申请日：2011-10-10
IPC分类号： A61K31/4439 , A61P7/02 , C12N9/99
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法和抑制血液样品凝固的方法。
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公开(公告)号：US20090030045A1
公开(公告)日：2009-01-29
申请号：US12166944
申请日：2008-07-02
IPC分类号： A61K31/4439 , C07D409/14 , A61P7/00 , A61P7/02
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法和抑制血液样品凝固的方法。
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公开(公告)号：US20070259924A1
公开(公告)日：2007-11-08
申请号：US11744735
申请日：2007-05-04
IPC分类号： A61K31/4439 , A61K31/4178 , A61K31/4172 , C07D403/02 , C07D409/02 , C07D405/02
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US08349873B2
公开(公告)日：2013-01-08
申请号：US13270170
申请日：2011-10-10
申请人： Yonghong Song , Zhaozhong J. Jia , Anjali Pandey , Robert M. Scarborough , Carroll Scarborough, legal representative
IPC分类号： A61K31/4412
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法和抑制血液样品凝固的方法。
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公开(公告)号：US20080293704A1
公开(公告)日：2008-11-27
申请号：US11969758
申请日：2008-01-04
IPC分类号： A61K31/4439 , C07D409/14 , A61K31/4545 , A61K31/541 , A61P7/00 , A01N1/00 , A61K31/496 , C07D279/12
CPC分类号： C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat certain conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这些化合物的中间体，含有这些化合物的药物组合物，预防或治疗特征在于不想要的血栓形成的某些病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20120142671A1
公开(公告)日：2012-06-07
申请号：US13287005
申请日：2011-11-01
申请人： Zhaozhong J. Jia , Yonghong Song , Qing Xu , Brian Kane , Shawn M. Bauer , Anjali Pandey
发明人： Zhaozhong J. Jia , Yonghong Song , Qing Xu , Brian Kane , Shawn M. Bauer , Anjali Pandey
IPC分类号： A61K31/166 , C07D209/08 , A61K31/404 , C07D249/06 , A61K31/4192 , C07D275/03 , A61K31/425 , C07D417/12 , A61K31/4439 , C07D413/12 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P29/00 , A61P37/00 , A61P7/04 , A61P7/06 , A61P9/10 , A61P37/08 , A61P11/06 , A61P35/00 , A61P1/00 , A61P3/00 , A61P19/04 , A61P17/06 , A61P25/00 , A61P35/02 , C12N9/99 , C12N5/02 , C07C237/30
CPC分类号： C07C237/42 , C07C237/30 , C07C2601/14 , C07D209/08 , C07D209/40 , C07D213/74 , C07D213/82 , C07D231/12 , C07D231/38 , C07D233/56 , C07D239/48 , C07D249/06 , C07D249/08 , C07D257/04 , C07D261/14 , C07D275/03 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
摘要翻译： 本发明涉及作为Syk激酶抑制剂的式I化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这些化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗数字的方法 的条件至少部分地由Syk激酶活性介导，例如非霍奇金淋巴瘤。
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公开(公告)号：US08063058B2
公开(公告)日：2011-11-22
申请号：US12386525
申请日：2009-04-16
申请人： Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
发明人： Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
IPC分类号： A01N43/54 , A61K31/505 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要翻译： 本发明涉及作为syk激酶抑制剂的式I-V化合物及其互变异构体或其药学上可接受的盐，酯和前体药物。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗数字的方法 至少部分通过syk激酶活性介导的病症，例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号：US07767697B2
公开(公告)日：2010-08-03
申请号：US12166944
申请日：2008-07-02
申请人： Yonghong Song , Zhaozhong J. Jia , Anjali Pandey
发明人： Yonghong Song , Zhaozhong J. Jia , Anjali Pandey
IPC分类号： A61K31/4412 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，含有这种化合物的药物组合物，预防或治疗许多不希望的血栓形成特征的病症的方法和抑制血液样品凝固的方法。
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