公开(公告)号：US08697635B2

公开(公告)日：2014-04-15

申请号：US13320737

申请日：2010-05-12

申请人： Yoon Keun Kim ,  Yong Song Gho ,  You Me Tae ,  Yoe Sik Bae ,  Sung Ho Ryu

发明人： Yoon Keun Kim ,  Yong Song Gho ,  You Me Tae ,  Yoe Sik Bae ,  Sung Ho Ryu

IPC分类号： A61K38/08

CPC分类号： A61K38/08 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/12 ,  A61K38/06 ,  A61K38/07

摘要： The present application relates to a pharmaceutical preparation to be administered into respiratory organs for treating or preventing inflammatory respiratory diseases, comprising a peptide which acts on formyl peptide receptors (FPRs) or receptors analogous thereto, in an amount which is effective in suppressing respiratory inflammation. The present application also relates to a method for treating or preventing inflammatory respiratory diseases by using the preparation, and to a kit containing the preparation. As compared with systemic administration of the peptide by injection, direct administration of the peptide to respiratory organs remarkedly improves the effect in suppressing respiratory inflammation.

摘要翻译： 本申请涉及用于治疗或预防炎症性呼吸系统疾病的呼吸器官中的药物制剂，其含量以有效抑制呼吸道炎症的量包含作用于甲酰基肽受体（FPR）或与其类似的受体的肽。 本申请还涉及通过使用制剂治疗或预防炎症性呼吸道疾病的方法，以及含有该制剂的试剂盒。 与通过注射的肽的全身给药相比，将肽直接给予呼吸器官显着提高了抑制呼吸道炎症的效果。

公开(公告)号：US08937038B2

公开(公告)日：2015-01-20

申请号：US13880889

申请日：2011-10-19

申请人： Yoe Sik Bae ,  Sang Doo Kim

发明人： Yoe Sik Bae ,  Sang Doo Kim

IPC分类号： C07K5/097 ,  A61K38/06

CPC分类号： C07K5/0823 ,  A61K38/06

摘要： A therapeutic agent for treating an infectious or inflammatory disease, a pharmaceutical composition for treating an infectious or inflammatory disease, and a method of using a pharmaceutical composition are provided. The pharmaceutical composition includes a peptide ligand that binds with CXCR2 as an active component. The active component can be useful in preventing and treating infectious and/or inflammatory diseases, including sepsis and septic shock by promoting the removal of bacteria by phagocytosis, suppressing an inflammatory response, and suppressing the apoptosis of immune cells.

摘要翻译： 提供治疗感染性或炎性疾病的治疗剂，用于治疗感染性或炎性疾病的药物组合物和使用药物组合物的方法。 药物组合物包括与CXCR2作为活性成分结合的肽配体。 通过促进细菌吞噬，抑制炎性反应，抑制免疫细胞凋亡，可以有效地预防和/或治疗感染性和/或炎性疾病，包括败血症和败血性休克。

公开(公告)号：US20140005271A1

公开(公告)日：2014-01-02

申请号：US14005737

申请日：2012-03-14

申请人： Yoe Sik Bae ,  Sang Doo Kim

发明人： Yoe Sik Bae ,  Sang Doo Kim

IPC分类号： A61K31/18 ,  A61K31/192

CPC分类号： A61K31/18 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/192 ,  A61K47/20 ,  A23V2200/324

摘要： Provided herein are a composition for preventing or treating inflammatory diseases or infectious diseases which contains m-3M3FBS or a pharmaceutically available salt thereof as an active ingredient, and health supplements for improving or preventing inflammatory diseases or infectious diseases which contain m-3M3FBS. Since m-3M3FBS has a microbicidal effect, inhibition of apoptosis, and inhibition of LPS-involved signal transduction which enables to effectively treat or prevent inflammatory diseases or infectious diseases, so that it may be effectively used as medicine or health supplements for treating or preventing inflammatory diseases or infectious diseases.

摘要翻译： 本文提供了用于预防或治疗含有m-3M3FBS或其药学上可用的盐作为活性成分的炎性疾病或感染性疾病的组合物，以及用于改善或预防含有m-3M3FBS的炎性疾病或感染性疾病的健康补充剂。 由于m-3M3FBS具有杀菌作用，抑制细胞凋亡，抑制LPS相关的信号转导，能够有效治疗或预防炎性疾病或传染病，从而可有效地用作治疗或预防的药物或保健品 炎性疾病或传染病。

公开(公告)号：US20130252878A1

公开(公告)日：2013-09-26

申请号：US13880889

申请日：2011-10-19

申请人： Yoe Sik Bae ,  Sang Doo Kim

发明人： Yoe Sik Bae ,  Sang Doo Kim

IPC分类号： C07K5/097

CPC分类号： C07K5/0823 ,  A61K38/06

摘要： A therapeutic agent for treating an infectious or inflammatory disease, a pharmaceutical composition for treating an infectious or inflammatory disease, and a method of using a pharmaceutical composition are provided. The pharmaceutical composition includes a peptide ligand that binds with CXCR2 as an active component. The active component can be useful in preventing and treating infectious and/or inflammatory diseases, including sepsis and septic shock by promoting the removal of bacteria by phagocytosis, suppressing an inflammatory response, and suppressing the apoptosis of immune cells.

摘要翻译： 提供治疗感染性或炎性疾病的治疗剂，用于治疗感染性或炎性疾病的药物组合物和使用药物组合物的方法。 药物组合物包括与CXCR2作为活性成分结合的肽配体。 通过促进细菌吞噬，抑制炎性反应，抑制免疫细胞凋亡，可以有效地预防和/或治疗感染性和/或炎性疾病，包括败血症和败血性休克。

公开(公告)号：US09468616B2

公开(公告)日：2016-10-18

申请号：US14005737

申请日：2012-03-14

申请人： Yoe Sik Bae ,  Sang Doo Kim

发明人： Yoe Sik Bae ,  Sang Doo Kim

IPC分类号： A61K31/18 ,  A61K31/192 ,  A23L1/30 ,  A61K9/20 ,  A61K9/00 ,  A61K47/20 ,  A61K9/08 ,  A61K9/48

CPC分类号： A61K31/18 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/192 ,  A61K47/20 ,  A23V2200/324

摘要： Provided herein are a composition for preventing or treating inflammatory diseases or infectious diseases which contains m-3M3FBS or a pharmaceutically available salt thereof as an active ingredient, and health supplements for improving or preventing inflammatory diseases or infectious diseases which contain m-3M3FBS. Since m-3M3FBS has a microbicidal effect, inhibition of apoptosis, and inhibition of LPS-involved signal transduction which enables to effectively treat or prevent inflammatory diseases or infectious diseases, so that it may be effectively used as medicine or health supplements for treating or preventing inflammatory diseases or infectious diseases.

摘要翻译： 本文提供了用于预防或治疗含有m-3M3FBS或其药学上可用的盐作为活性成分的炎性疾病或感染性疾病的组合物，以及用于改善或预防含有m-3M3FBS的炎性疾病或感染性疾病的健康补充剂。 由于m-3M3FBS具有杀菌作用，抑制细胞凋亡，抑制LPS相关的信号转导，能够有效治疗或预防炎性疾病或传染病，从而可有效地用作治疗或预防的药物或保健品 炎性疾病或传染病。