公开(公告)号：US20120192295A1

公开(公告)日：2012-07-26

申请号：US13499653

申请日：2010-08-05

申请人： Yoon Keun Kim ,  Yong Song Gho ,  Yu Sun Kim ,  Eun Jeong Choi ,  Sung Wook Hong ,  Eun Young Lee ,  Bok Sil Hong ,  Jun Pyo Choi ,  Young Koo Ji

发明人： Yoon Keun Kim ,  Yong Song Gho ,  Yu Sun Kim ,  Eun Jeong Choi ,  Sung Wook Hong ,  Eun Young Lee ,  Bok Sil Hong ,  Jun Pyo Choi ,  Young Koo Ji

IPC分类号： A61K39/02 ,  A01K67/00 ,  A61K49/00 ,  G01N33/53 ,  A61P31/00 ,  A61K39/116 ,  C12Q1/04 ,  C12Q1/68 ,  A61L9/00 ,  C12N1/00 ,  A61K39/00

CPC分类号： G01N33/5088 ,  G01N2800/122

摘要： The present application relates to a composition comprising extracellular membrane vesicles derived from indoor air. In addition, the present application provides a method for diagnosing, preventing and/or treating an inflammatory respiratory disease, lung cancer and the like using the extracellular membrane vesicles. In detail, the present application involves injecting extracellular membrane vesicles present in indoor air into an animal in order to prepare an animal respiratory disease model, and enables the search and/or discovery of drug candidates for preventing or treating respiratory diseases using the animal model. The present application provides a vaccine for preventing and/or treating respiratory diseases, to a method for diagnosing substances causing respiratory diseases, and to a method for inhibiting the activities of extracellular membrane vesicles in indoor air or removing the extracellular membrane vesicles from indoor air so as to prevent the occurrence and exacerbation of respiratory diseases.

摘要翻译： 本申请涉及包含从室内空气衍生的细胞外膜泡的组合物。 此外，本申请提供了使用细胞外膜囊泡诊断，预防和/或治疗炎性呼吸系统疾病，肺癌等的方法。 详细地说，本申请涉及将存在于室内空气中的细胞外膜囊泡注射到动物体内，以制备动物呼吸系统疾病模型，并使用动物模型能够搜寻和/或发现候选药物预防或治疗呼吸系统疾病。 本申请提供了用于预防和/或治疗呼吸系统疾病的疫苗，用于诊断引起呼吸系统疾病的物质的方法，以及用于抑制室内空气中的细胞外膜泡的活性或从室内空气中除去细胞外膜泡的方法 以防止呼吸系统疾病的发生和恶化。

公开(公告)号：US08691522B2

公开(公告)日：2014-04-08

申请号：US13499653

申请日：2010-08-05

申请人： Yoon Keun Kim ,  Yong Song Gho ,  Yu Sun Kim ,  Eun Jeong Choi ,  Sung Wook Hong ,  Eun Young Lee ,  Bok Sil Hong ,  Jun Pyo Choi ,  Young Koo Ji

发明人： Yoon Keun Kim ,  Yong Song Gho ,  Yu Sun Kim ,  Eun Jeong Choi ,  Sung Wook Hong ,  Eun Young Lee ,  Bok Sil Hong ,  Jun Pyo Choi ,  Young Koo Ji

IPC分类号： C12Q1/04

CPC分类号： G01N33/5088 ,  G01N2800/122

摘要： The present application relates to a composition comprising extracellular membrane vesicles derived from indoor air. In addition, the present application provides a method for diagnosing, preventing and/or treating an inflammatory respiratory disease, lung cancer and the like using the extracellular membrane vesicles. In detail, the present application involves injecting extracellular membrane vesicles present in indoor air into an animal in order to prepare an animal respiratory disease model, and enables the search and/or discovery of drug candidates for preventing or treating respiratory diseases using the animal model. The present application provides a vaccine for preventing and/or treating respiratory diseases, to a method for diagnosing substances causing respiratory diseases, and to a method for inhibiting the activities of extracellular membrane vesicles in indoor air or removing the extracellular membrane vesicles from indoor air so as to prevent the occurrence and exacerbation of respiratory diseases.

摘要翻译： 本申请涉及包含从室内空气衍生的细胞外膜泡的组合物。 此外，本申请提供了使用细胞外膜囊泡诊断，预防和/或治疗炎性呼吸系统疾病，肺癌等的方法。 详细地说，本申请涉及将存在于室内空气中的细胞外膜囊泡注射到动物体内，以制备动物呼吸系统疾病模型，并使用动物模型能够搜寻和/或发现候选药物预防或治疗呼吸系统疾病。 本申请提供了用于预防和/或治疗呼吸系统疾病的疫苗，用于诊断引起呼吸系统疾病的物质的方法，以及用于抑制室内空气中的细胞外膜泡的活性或从室内空气中除去细胞外膜泡的方法 以防止呼吸系统疾病的发生和恶化。