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    Multi-targets interfering RNA molecules and their applications
    1.
    发明授权
    Multi-targets interfering RNA molecules and their applications 有权
    多靶点干扰RNA分子及其应用

    公开(公告)号：US09115167B2

    公开(公告)日：2015-08-25

    申请号：US13415600

    申请日：2012-03-08

    申请人： York YuanYuan Zhu ,  TieJun Li

    发明人： York YuanYuan Zhu ,  TieJun Li

    IPC分类号： C07H21/02 ,  A61K31/7088

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/52 ,  C12N2310/53 ,  C12N2310/531

    摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.

    摘要翻译： 本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。 所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

    MULTI-TARGETS INTERFERING RNA MOLECULES AND THEIR APPLICATIONS
    2.
    发明申请
    MULTI-TARGETS INTERFERING RNA MOLECULES AND THEIR APPLICATIONS 有权
    多靶点干扰RNA分子及其应用

    公开(公告)号：US20120232126A1

    公开(公告)日：2012-09-13

    申请号：US13415600

    申请日：2012-03-08

    申请人： York YuanYuan Zhu ,  TieJun Li

    发明人： York YuanYuan Zhu ,  TieJun Li

    IPC分类号： A61K31/7088 ,  A61P31/12 ,  A61P35/00 ,  C07H21/02

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/52 ,  C12N2310/53 ,  C12N2310/531

    摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.

    摘要翻译： 本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。 所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链的长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

    HBV treatment
    3.
    发明授权
    HBV treatment 有权
    HBV治疗

    公开(公告)号：US09080174B2

    公开(公告)日：2015-07-14

    申请号：US13882124

    申请日：2011-10-27

    申请人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    发明人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    IPC分类号： C07H21/04 ,  C12N15/113

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/531

    摘要： RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.

    摘要翻译： 提供RNA干扰（RNAi）试剂和使用RNAi试剂治疗个体中的乙型肝炎感染，以及含有RNAi试剂的药物组合物。 用于表达它们的RNAi剂或构建体用于抑制至少一种乙型肝炎病毒（HBV）基因的表达，其中每种试剂包含与从靶区转录的预测序列互补或基本上互补的效应序列。 在本发明的一些实施方案中，所述试剂具有多于一个效应序列; 其中所述多个效应子可以靶向相同基因和/或不同HBV基因的HBV基因的相同区域，不同（可能重叠的）区域。